Gabriela Sadigurschi,Maria Cristina Caetano Kuschnir,Ewerton Alves Portela Dos Santos et al.
Gabriela Sadigurschi et al.
Tuberculosis (TB) is a preventable and curable disease caused by the bacillus Mycobacterium tuberculosis. In 2022, according to the World Health Organisation (WHO), TB was the second leading cause of death worldwide caused by a single infec...
Detection of immunogenic protein components in excretion/secretion products of Acanthamoeba T5 using polyclonal antibodies [0.03%]
利用多克隆抗体检测溶组织内阿米巴T5株分泌/排泄蛋白的抗原成分
Lissette Retana-Moreira,Elizabeth Abrahams-Sandí,Marco Ruiz-Campos et al.
Lissette Retana-Moreira et al.
Background: Acanthamoeba is a free-living amoeba widely distributed, responsible for keratitis and granulomatous amoebic encephalitis. The presence of virulence factors in its excretion/secretion products has been demonst...
Parasitological cure and clinical benefits of benznidazole treatment in patients from the Jequitinhonha Valley, MG, Brazil, with recent chronic infection by Trypanosoma cruzi II [0.03%]
巴西米纳斯吉拉斯州杰凯廷尤纳河谷地区II型感染慢性期查格斯病患者苯硝唑治疗的根治与临床效益
Marta de Lana,Lourena Tomazelli Suave,Júlio César Santoro de Oliveira Assis et al.
Marta de Lana et al.
Background: The treatment of the early chronic phase of Chagas disease (CD) may result in high rates of parasitological cure, which may be associated with clinical benefits. ...
Use of Brazilian flora as the main source of new antimalarials: a systematic review [0.03%]
利用巴西植物作为新型抗疟药的主要来源：一项系统性综述
Ana Rafaela Antunes Porto,Isabela de Brito Duval,Luisa Vitor Braga do Amaral et al.
Ana Rafaela Antunes Porto et al.
Plants represent an important source of compounds for treating malaria, highlighting the rich biodiversity of Brazilian flora as a vital resource for developing new, effective antimalarial drugs. The present study sought to shed light on th...
Miltefosine analogues with comparable antileishmanial activity and significantly reduced macrophage cytotoxicity [0.03%]
与阳性对照剂米替福新具有类似抗病原虫活性且巨噬细胞毒性显著降低的米替福新产品
Lais Alonso,Laís Flávia Nunes Lemes,George E Magoulas et al.
Lais Alonso et al.
Background: Miltefosine (MIL) is the only oral drug approved for leishmaniasis treatment, but its use is limited by gastrointestinal toxicity. Novel alkylphospholipid analogues may provide safer and more effective alterna...
Comparative Study
Memorias do Instituto Oswaldo Cruz. 2025 May 26:120:e240219. DOI:10.1590/0074-02760240219 2025
Anti-PGL-I seropositivity and development of leprosy in contacts: a comprehensive analysis of sociodemographic determinants, genetic susceptibility, and exposure characteristics to Mycobacterium leprae [0.03%]
抗PGL-I阳性与接触者麻风病的发展：社会人口决定因素、遗传易感性和暴露于麻风分枝杆菌特征的全面分析
Eyleen Nabyla Alvarenga Niitsuma,Isabela de Caux Bueno,Gabriel da Rocha Fernandes et al.
Eyleen Nabyla Alvarenga Niitsuma et al.
Background: Leprosy is an infectious disease that remains hyperendemic in several Brazilian regions. Patient contacts face a higher risk for infection and illness, which can subsequently contribute to the persistence of t...
Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Ceará, northeastern Brazil [0.03%]
巴西塞阿拉州肺结核和肺外结核的IFN-γ、TNF-α、IL-6、IL-10和TGF-β单核苷酸多态性研究
Roberta Dos Santos Silva Luiz,Thales Alves Campelo,Caroliny Soares Silva et al.
Roberta Dos Santos Silva Luiz et al.
Background: Single nucleotide polymorphisms (SNP) in genes encoding cytokines influence tuberculosis (TB) outcomes. Objectives: To char...
Impact of dengue virus infection on the cytoadherence of Plasmodium vivax-infected erythrocytes [0.03%]
登革病毒感染对恶性疟原虫感染红细胞黏附性的影响
Maria Geuziane Soares da Cruz,Rafaella Oliveira Dos Santos,Maria Gloria Teixeira Sousa et al.
Maria Geuziane Soares da Cruz et al.
Background: Coinfections of Plasmodium parasites and the dengue virus have been linked to severe disease in some patients. The interactions between these two pathogens, particularly their effects on disease progression, h...
Pandemic ST131 Escherichia coli presenting the UPEC/EAEC and ExPEC/EAEC hybrid pathotypes recovered from extraintestinal infections in a clinical setting of the Brazilian Amazon region [0.03%]
在巴西亚马逊地区临床环境中从泌尿道和肠道外感染中分离出的具有UPEC / EAEC和ExPEC / EAEC杂交病原体类型的 pandemic ST131 型大肠杆菌
Nathália Ms Bighi,Érica Lourenço Fonseca,Fernanda S Freitas et al.
Nathália Ms Bighi et al.
Background: Escherichia coli is a commensal organism but may become pathogenic by the acquisition of virulence factors involved with intestinal (IPEC) or extraintestinal (ExPEC) infections. Some strains, known as hybrids,...
Agglomerative hierarchical cluster analysis and temporal trend of leprosy indicators in Brazilian states, 2012-2022 [0.03%]
2012-2022年巴西各州麻风病指标的群集层次聚类分析及时间趋势
Lúcia Rolim Santana de Freitas,Fernanda Fernandez Nóbrega
Lúcia Rolim Santana de Freitas
Background: Leprosy, a neglected tropical disease caused by Mycobacterium leprae, presents significant public health challenges in Brazil due to its slow progression, dermato-neurological manifestations, and potential for...