Association of p-glycoprotein and bile salt export pump gene polymorphisms with advanced liver disease in hepatitis C virus infected patients [0.03%]
P-糖蛋白和胆盐出口泵基因多态性与慢性丙型肝炎患者重症化的关系研究
Letícia Bomfim Campos,Nathália Alves Araújo de Almeida,Marcia Maria Amendola Pires et al.
Letícia Bomfim Campos et al.
Background: Single-nucleotide polymorphisms (SNPs) can influence the hepatitis C virus (HCV) infection and progression. ABCB1-gene SNPs - c.1236C>T, c.2677G>T and c.3435C>T - are associated with drug efficacy, hepatotoxic...
Piecing together the puzzle: current knowledge and open questions about the Klebsiella pneumoniae type VI secretion system (T6SS) [0.03%]
拼图拼凑：肺炎克雷伯氏菌型VI分泌系统（T6SS）的当前知识和开放性问题
Leticia Miranda Santos Lery,Paulo Ricardo Batista
Leticia Miranda Santos Lery
Klebsiella pneumoniae (Kp) is currently a top priority for the development of alternative therapeutic strategies, according to the World Health Organisation, due to serious concerns regarding infections caused by multiple drug resistant (MD...
Evaluation of the in vitro activity of synthetic derivatives of N-cyclohexyl-3-(3-methylphenyl)-1,2,4-oxadiazole-5-amine on the strain y of Trypanosoma cruzi and an in vivo toxicity study [0.03%]
N-环己基-3-(3-甲基苯基)-1,2,4-恶二唑-5-胺合成衍生物对克氏锥虫Y株的体外活性评价及其体内毒性研究
Yasmim Mendes Rocha,Lyanna Rodrigues Ribeiro,Gabriel Acácio de Moura et al.
Yasmim Mendes Rocha et al.
Background: Chagas disease (CD) is caused by Trypanosoma cruzi. Treatment is based on benznidazole (Bz), although it has significant limitations, such as low efficacy in the chronic phase. Therefore, the search for new th...
Cladistics of South American Triatoma (Hemiptera: Reduviidae): a morphological overview of T. infestans complex [0.03%]
南美Triatoma的 cladistics（Hemiptera: Reduviidae）：T. infestans 复合体形态概述
João Paulo Sales Oliveira-Correia,Hélcio Reinaldo Gil-Santana,Cleber Galvão
João Paulo Sales Oliveira-Correia
Background: Triatoma infestans complex comprises 39 species of South American triatomines, organised into different subcomplexes. These species act as vectors of the protozoan Trypanosoma cruzi, the etiological agent of C...
In vitro anti-Trypanosomatid activity and chemical profile of crude extracts of Chromolaena hookeriana and Campuloclinium macrocephalum (Asteraceae) [0.03%]
基于植物的抗密丝胞属有面盘亚目的化学成分和体外活性研究：钩脉轮环菊和粗茎轮环菊（菊科）的粗提物的研究
Ludmila Ferreira de Almeida Fiuza,Ketlym da Conceição,Krislayne Nunes et al.
Ludmila Ferreira de Almeida Fiuza et al.
Background: Chagas disease (CD) and Leishmaniasis, caused by Trypanosoma cruzi and Leishmania species, are treated with outdated drugs that are toxic and have limited efficacy. New therapeutic alternatives are therefore n...
Comparative bioavailability of three benznidazole formulations in healthy individuals: a randomised study [0.03%]
Healthy受试者中三种苯硝唑剂型生物等效性的随机研究
Gabriel Parreiras Estolano da Silveira,Laís Bastos da Fonseca,Rita Estrela et al.
Gabriel Parreiras Estolano da Silveira et al.
Background: Benznidazole (BZN) has been used for more than fifty years in the treatment of Chagas disease (CD). It is produced by only three pharmaceutical companies worldwide: Lafepe (Brazil); Elea (Argentina) and Licons...
Randomized Controlled Trial
Memorias do Instituto Oswaldo Cruz. 2026 Jul 10;121(suppl 2):e250307. DOI:10.1590/0074-02760250307 2026
Advances and challenges in the search for new treatments for Chagas disease [0.03%]
恰加斯病新治疗方法的研究进展与挑战
Ana Maria Murta Santi,Davi Alvarenga Lima,Silvane Maria Fonseca Murta
Ana Maria Murta Santi
The treatment of Chagas disease (CD) has relied for more than five decades on two drugs, benznidazole (BZ) and nifurtimox (NTX), both with significant limitations and severe adverse effects. Their limited efficacy during the chronic phase u...
Evidence of insecticide resistance in Aedes aegypti populations of Suriname: first report of malathion resistance and presence of the kdr mutations V410L, V1016I and F1534C [0.03%]
苏里南埃及伊蚊种群中杀虫剂抗性的证据：马拉硫磷抗性和kdr突变V410L、V1016I和F1534C首次报告
Kartika Doerdjan-Ramoutar,Jerry Toelsie,Amandine Guidez et al.
Kartika Doerdjan-Ramoutar et al.
Background: Dengue outbreaks pose a significant public health risk in Suriname, with challenges in mosquito surveillance and limited data on insecticide resistance hampering control efforts. ...
Determinants of HIV-1 virologic suppression in HIV-associated tuberculosis in Brazil [0.03%]
巴西艾滋病相关结核病患者HIV-1病毒抑制的影响因素
Felipe Ridolfi,Gustavo Amorim,David W Haas et al.
Felipe Ridolfi et al.
Background: Tuberculosis/human immunodeficiency virus (TB/HIV) coinfection is associated with advanced HIV disease and variable responses to antiretroviral therapy (ART). ...
Observational Study
Memorias do Instituto Oswaldo Cruz. 2026 Jul 10:121:e250090. DOI:10.1590/0074-02760250090 2026
Severity of COVID-19 in hospitalised children in Espírito Santo, Brazil: a comparative analysis of pre- and post-Omicron periods [0.03%]
巴西埃斯皮里图圣蒂地区住院儿童新冠重症情况： Omicron前后时期比较分析
Brena Ramos Athaydes,Mariane Vedovatti Monfardini,Juliana Santa Ardisson et al.
Brena Ramos Athaydes et al.
Background: Children experience Coronavirus disease 2019 (COVID-19) often with milder symptoms but severe outcomes. Objectives: To comp...
Observational Study
Memorias do Instituto Oswaldo Cruz. 2026 Jul 10:121:e250018. DOI:10.1590/0074-02760250018 2026