Testicular CYP3A triggers BDE47-induced spermatogenic cell ferritinophagy via ROS-ALKBH5-m 6A-ATG12 pathway [0.03%]
睾丸CYP3A通过ROS-ALKBH5-m6A-ATG12信号通路触发多氯联苯诱导的精原细胞铁死亡
Shuyu Xu,Wenxia Fan,Jiangxue Qian et al.
Shuyu Xu et al.
Cytochrome P450 CYP3A (CYP3A) is the most abundant metabolic enzyme in the liver and also mediates the metabolism and toxicity of xenobiotics. Previous studies have reported that CYP3A is also expressed in the testis; however, its role and ...
The negative chronotropic control of the insula: An SEEG-based investigation [0.03%]
岛叶对心率的减慢控制作用：一种SEEG研究方法
Zhaoyou Huang,Hao Yan,Zhenxing Li et al.
Zhaoyou Huang et al.
The insula is implicated in heart rate modulation within brain-cardiac interactions, yet direct electrophysiological evidence remains limited. This study investigates dynamic insula-cardiac coupling during ictal heart rate fluctuations to e...
Integrative genomic and metabolomic analyses identify novel associations between mQTLs and common diseases in Han Chinese [0.03%]
整合基因组和代谢组分析鉴定出汉族人群中与mQTLs相关的新关联的常见疾病
Jiaying Cai,Jiahao Zhang,Yating Fu et al.
Jiaying Cai et al.
While prior metabolomic genome-wide association studies (mGWASs) have identified numerous metabolite quantitative trait loci (mQTLs) in European populations, their characterization in East Asians-particularly Han Chinese-remains limited. He...
Microbiota-metabolite axis in endometriosis: Pathogenic mechanisms and clinical implications [0.03%]
子宫内膜异位症的微生态-代谢轴：发病机制与临床意义
Moyuan Li,Aiyuan Yue,Lingfeng Gu et al.
Moyuan Li et al.
Growing evidence highlights the role of microbiota, including those of the gut, reproductive tract, and endometrial tissue, as critical functional drivers in the pathogenesis of endometriosis (EM). Studies have revealed a characteristic mic...
Progressive IL-13 signaling promotes inflammation-associated liver fibrosis via IL-13RA2/MEK/ERK activation in Schistosoma japonicum infection [0.03%]
进行性IL-13信号通过IL-13RA2/MEK/ERK活化促进日本血吸虫感染相关的肝纤维炎症反应
Ruiyan Xiong,Jiangyuan Du,Yuchen Yang et al.
Ruiyan Xiong et al.
Progressive IL-13 signaling is closely associated with liver fibrosis. Among fibrotic diseases, liver fibrosis induced by Schistosoma japonicum in advanced schistosomiasis is the primary driver of portal hypertension, which is the leading c...
Combating Pseudomonas aeruginosa biofilms: Pathogenesis, resistance mechanisms and novel treatment approaches in an era of emerging antimicrobial resistance [0.03%]
应对抗微生物药物耐药时代绿脓杆菌生物被膜形成：发病机制、抗性机制和新的治疗策略
Sachin Kumar Sharma,Tsering Yangzom,Dhruva Kumar Sharma
Sachin Kumar Sharma
Biofilms are complex associations of microorganisms that are adhere to both biotic surfaces ( e.g., living tissues) and abiotic surfaces ( e.g., medical implants). These microorganisms, embedded in their own self-produced extracellular poly...
Evaluating sleep and dietary assessment within composite lifestyle scores: implications for mortality research in type 2 diabetes [0.03%]
评估睡眠和饮食评估在综合生活方式评分中的情况：2型糖尿病死亡率研究的启示
Nádia Raci Marques Pereira,Isabela Antunes Ishikura,Sergio Tufik et al.
Nádia Raci Marques Pereira et al.
Hypoxia-induced acidic microenvironment alters cellular pharmacokinetics of gastric cancer in a Mongolian population [0.03%]
缺氧诱导的酸性微环境改变蒙古族人群胃癌细胞药动学行为
Jiawen Cheng,Zhouyue Wu,Mengran Wang et al.
Jiawen Cheng et al.
This study aims to comprehensively analyze the transcriptome characteristics of Mongolian gastric cancer (GC) patients to elucidate the critical molecular events underlying treatment response in this ethnic population. The objective is to e...
Yafang Li,Xiongjie He,Jialin Lan et al.
Yafang Li et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and alpha-synuclein (α-syn) aggregation. Although current therapies alleviate symptoms, they fail to halt disease progre...
Bisphenol A impairs contractile function and vascular development in human cardiac organoids: Insights from toxicity assessment and risk evaluation [0.03%]
双酚A损害人源心脏类器官的收缩功能和血管发育：来自毒性评估与风险评估的启示
Linfeng Jiang,Yachang Wang,Huina Li et al.
Linfeng Jiang et al.
Bisphenol A (BPA), a widely encountered environmental endocrine-disrupting chemical, has been linked to an increased risk of congenital heart defects in epidemiological and experimental studies. To investigate its impact in a human-relevant...