Taxonomic diversity of fecal microbiota associated with different metabolic phenotypes in residents of Arkhangelsk, Northwestern Russia [0.03%]
俄罗斯西北部阿尔汉格尔斯克居民不同代谢表型相关粪便菌群的分类多样性
Anna Postoeva,Ekaterina Krieger,Anna Leontyeva et al.
Anna Postoeva et al.
The study aimed to assess the taxonomic diversity and composition of gut microbiota in Arkhangelsk residents, Northwestern Russia, with varying metabolic statuses. A population-based cross-sectional "Know Your Heart" study (2015-2017, parti...
CRISPR/Cas9-mediated genome editing reveals six testis-enriched genes dispensable for male fertility in mice [0.03%]
利用 CRISPR/Cas9 基因编辑揭示小鼠六个仅在睾丸中高表达但对雄性生育力非必需的基因
Heling Fu,Haoran Chen,Chenmeijie Li et al.
Heling Fu et al.
The genetic landscape of male infertility is highly complex. It is estimated that at least 1000-2000 genes are involved in human and mouse infertility. Although functional analyses have been performed on hundreds of genes, many others still...
NS3 epitope-decorated nanoparticles produced in bacteria trigger potent T cell immunity against hepatitis C virus [0.03%]
乙型肝炎病毒核心抗原表位装饰的纳米颗粒能够有效激活T细胞免疫反应
Victor V Kuprianov,Lyudmila I Nikolaeva,Maya D Stuchinskaya et al.
Victor V Kuprianov et al.
The highly conserved human leukocyte antigen-A2 (HLA-A2)-restricted epitope NS3-1073 represents a promising candidate for a therapeutic vaccine against hepatitis C virus (HCV). In this study, we engineered a set of fusion proteins based on ...
Opioids regulate the functional state of immune cells and reduce inflammatory cardiac injury: Role of opioid receptors, MRGPRX2, and TLR4 [0.03%]
阿片类药物通过调控免疫细胞功能状态及作用于多种受体减少心肌炎症损伤
Svetlana V Gusakova,Maria Sirotina,Leonid N Maslov et al.
Svetlana V Gusakova et al.
Neutrophils, macrophages, CD3 +, CD4 +, and CD8 + T-lymphocytes express µ-, δ-, and κ-opioid receptors (ORs) with both high and low affinities for opioids. Mast cells express the atypical OR mas-related G-protein-coupled receptor X2 (MRG...
Rongzhu Liu,Dongnan Zheng,Fengxu Wang et al.
Rongzhu Liu et al.
Pulmonary fibrosis (PF) is a progressive lung disorder characterized by excessive deposition of extracellular matrix (ECM) in the alveoli, with irreversible fibrotic remodeling and destruction of alveolar structures. Clinically, PF is manif...
The association between HPV infection and endometriosis: Risk and fertility outcomes [0.03%]
人乳头瘤病毒与子宫内膜异位症的相关性：风险和生育结局
Wenqu Li,Zhenlong Wang,Huizhi Qi et al.
Wenqu Li et al.
While infections have been implicated in endometriosis pathogenesis, the role of human papillomavirus (HPV) remains unclear. This study combined a meta-analysis of seven studies with a case-control study ( n = 432 surgically treated patient...
Editorial Board
Editorial Board
Tongyao Fu,Yan Ma,Yifei Jiang et al.
Tongyao Fu et al.
Ocular diseases, including corneal disease, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, and retinopathy of prematurity, can significantly impair vision and reduce the quality of life. Due to the fact that degener...
Stratified profiling of azoospermia: Differentiating histological subtypes with seminal plasma metabolic signatures [0.03%]
azoospermia分层特征分析：用精浆代谢标志物区分组织亚型
Jiachen Wang,Tianyi Song,Hongqi Fan et al.
Jiachen Wang et al.
Non-obstructive azoospermia (NOA), characterized by impaired spermatogenesis and the complete absence of sperm in the ejaculate, represents one of the most severe forms of male infertility. Current diagnostic strategies rely on invasive pro...
STK11 rs12977689 C>A gene polymorphism as a risk factor for coronary artery disease in type 2 diabetes patients [0.03%]
STK11基因rs12977689 C>A多态性在2型糖尿病患者冠心病发病中的作用研究
Made Edwin Sridana,Wira Gotera,Bagus Ari et al.
Made Edwin Sridana et al.