Helicobacter pylori-induced ADAMDEC1 overexpression in M2 macrophages drives preneoplastic progression in the gastric mucosa [0.03%]
幽门螺旋杆菌通过诱导M2巨噬细胞中ADAMDEC1过度表达驱动胃黏膜癌前病变进展
Haoxuan Kan,Guoyang Niu,Luyao Wang et al.
Haoxuan Kan et al.
Helicobacter pylori ( H. pylori) infection is a major risk factor for gastric cancer, though the immune microenvironmental factors driving preneoplastic transformation remain unclear. In this study, single-cell RNA sequencing was used to ch...
Analysis of the efficacy of a model for auxiliary diagnosis of aortic aneurysms based on clinical pathological features [0.03%]
基于临床病理特征的主动脉瘤辅助诊断模型效能分析
Dian Yu,Xiaoyun Song,Yuanze Ma et al.
Dian Yu et al.
This study evaluated a multi-parameter serological model for the auxiliary diagnosis of aortic aneurysm (AA). Clinical data and serological indicators were collected from 1397 AA patients and 2000 healthy controls recruited from the Second ...
Sestrin-2 and metabolic syndrome: Biochemical insights from a cross-sectional study [0.03%]
sestrin-2与代谢综合征：横断面研究中的生化启示
Surbhi Tyagi,Suryakant Nagtilak,Pawan Parashar
Surbhi Tyagi
Integrative machine learning reveals interplay between epithelial and endothelial cells elevates mixed heavy metal-related colorectal cancer risk [0.03%]
整合型机器学习揭示上皮细胞和内皮细胞互作增强混合重金属相关结直肠癌风险
Shuo Zhang,Yudan Zheng,Jing Wang et al.
Shuo Zhang et al.
Heavy metal contamination has become an emerging global health concern, yet the promoting effects of mixed heavy metal exposure on colorectal cancer risk remains poorly understood. In this study, plasma concentrations of 25 heavy metals wer...
Association of emotional and behavioral problems with Internet addiction among children and adolescents: A prospective cohort study [0.03%]
儿童和青少年网络成瘾与情绪及行为问题之间的关联：一项前瞻性队列研究
Qin Wang,Wenyi Yang,Yue Zhu et al.
Qin Wang et al.
The longitudinal associations between emotional and behavioral problems and Internet addiction, including how transitions between problem patterns influence risk, remain underexplored. This study investigated these associations using longit...
Lactobacillus murinus improves liver fibrosis in primary sclerosing cholangitis mice by decreasing taurocholic acid and regulating M2 macrophage polarization [0.03%]
乳酸菌Lactobacillus murinus通过降低牛磺胆酸和调节M2型巨噬细胞极化来改善原发性硬化性胆管炎小鼠的肝纤维化病情
Chenchen Zhang,Zixuan Wang,Dilixiati Kadier et al.
Chenchen Zhang et al.
Hepatic accumulation of bile acids (BAs) contributes to cholestasis-induced liver injury and fibrosis. Our previous studies have shown that Lactobacillus murinus ( L. murinus) alleviates liver fibrosis in primary sclerosing cholangitis (PSC...
Cardiomyocyte BMAL1 deficiency worsens obesity-related cardiomyopathy with heightened PINK1/Parkin-linked mitophagy and mitochondrial dysfunction [0.03%]
心脏成纤维细胞BMAL1缺乏通过增强PINK1/Parkin连接的线粒体自噬和线粒体功能障碍加重肥胖相关的心肌病
Tianzi Liu,Xiaoxuan Fan,Nannan Zhang et al.
Tianzi Liu et al.
Obesity-related cardiomyopathy (OCM) is characterized by pathological cardiac remodeling and progressive functional decline, often accompanied by mitochondrial dysfunction, particularly aberrant mitophagy. The role of the core circadian gen...
Testicular CYP3A triggers BDE47-induced spermatogenic cell ferritinophagy via ROS-ALKBH5-m 6A-ATG12 pathway [0.03%]
睾丸CYP3A通过ROS-ALKBH5-m6A-ATG12信号通路触发多氯联苯诱导的精原细胞铁死亡
Shuyu Xu,Wenxia Fan,Jiangxue Qian et al.
Shuyu Xu et al.
Cytochrome P450 CYP3A (CYP3A) is the most abundant metabolic enzyme in the liver and also mediates the metabolism and toxicity of xenobiotics. Previous studies have reported that CYP3A is also expressed in the testis; however, its role and ...
The negative chronotropic control of the insula: An SEEG-based investigation [0.03%]
岛叶对心率的减慢控制作用：一种SEEG研究方法
Zhaoyou Huang,Hao Yan,Zhenxing Li et al.
Zhaoyou Huang et al.
The insula is implicated in heart rate modulation within brain-cardiac interactions, yet direct electrophysiological evidence remains limited. This study investigates dynamic insula-cardiac coupling during ictal heart rate fluctuations to e...
Integrative genomic and metabolomic analyses identify novel associations between mQTLs and common diseases in Han Chinese [0.03%]
整合基因组和代谢组分析鉴定出汉族人群中与mQTLs相关的新关联的常见疾病
Jiaying Cai,Jiahao Zhang,Yating Fu et al.
Jiaying Cai et al.
While prior metabolomic genome-wide association studies (mGWASs) have identified numerous metabolite quantitative trait loci (mQTLs) in European populations, their characterization in East Asians-particularly Han Chinese-remains limited. He...