Comparison of Pregnancy Outcomes and Vaginal Microbiota in Endometriosis Patients Undergoing Frozen Embryo Transfer Using Letrozole Combined HMG Versus Hormone Replacement Therapy with GnRH-a Pretreatment [0.03%]
来曲唑联合HMG与GnRH-a降调节人工周期黄体支持的冻融胚胎移植临床结局及子宫微生态比较研究
Jie Zhang,Lei Dai,Chunyan Jiang et al.
Jie Zhang et al.
This study investigated differences in reproductive outcomes and vaginal microbiota profiles between two endometrial preparation protocols-letrozole (LE) combined with human menopausal gonadotropin (HMG) and hormone replacement therapy (HRT...
Overexpression of DDR1 contributes to gastric cancer progression via inhibition of Hippo pathway [0.03%]
DDR1过表达通过抑制Hippo信号通路促进胃癌进展
Haiying Han,Tianqi Shen,Tingting Zhou et al.
Haiying Han et al.
Gastric cancer (GC) is a prevalent and devastating disease with poor prognosis. Lack of biomarkers for early detection and effective targeted therapeutics for GC patients represent two major challenges for this disease. Through iTRAQ-LC-MS/...
Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases [0.03%]
交叉表型的全基因组关联研究支持皮肤和胃肠道疾病具有相同的遗传病因
Bo Peng,Minghui Jiang,Si Li et al.
Bo Peng et al.
The comorbidity of skin and gastrointestinal tract (GIT) diseases, primarily driven by the gut-skin axis (GSA), is well-known. However, the genetic contribution to the GSA remains unclear. Here, using genome-wide association study (GWAS) su...
Mechanisms and targets of harnessing Culex pipiens-specific antibodies as a novel vector control strategy [0.03%]
利用专门针对Culex pipiens的抗体作为新型控制策略的机制和靶点
Xuebin Zhao,Jian Zheng,Weimin Zheng et al.
Xuebin Zhao et al.
Mosquito-borne diseases pose a significant global health threat, necessitating novel vector control strategies. This study explores the potential of harnessing the host immunity against mosquitoes through vaccination. Using Culex pipiens ( ...
Remote neuromuscular electrical stimulation upregulates MDK to enhance macrophage efferocytosis via LRP1 in wound healing [0.03%]
远程神经肌肉电刺激通过LRP1上调MDK以增强巨噬细胞的凋亡细胞吞噬作用从而促进伤口愈合
Lijuan Zong,Chong Liu,Li Zhang et al.
Lijuan Zong et al.
Neuromuscular electrical stimulation (NMES) is a well-established therapeutic approach for chronic wounds. Conventionally, NMES involves direct electrode contact with wounds or adjacent healthy skin; however, it is limited by the need for w...
Probiotic Akkermansia muciniphila alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites [0.03%]
乳酸菌Akkermansia muciniphila通过保护肠屏障和调节肠道微生物群和代谢物来缓解急性肾损伤
Juan Ni,Zhan Yang,Xuewei Sun et al.
Juan Ni et al.
Acute kidney injury (AKI) is a critical condition with limited effective therapies. Akkermansia muciniphila ( A. muciniphila) is a probiotic with multiple beneficial effects, including epithelial cell tight junctions regulation. Since renal...
A healthy lifestyle pattern and mortality risk in patients of type 2 diabetes mellitus: a prospective cohort study in China [0.03%]
健康生活方式与2型糖尿病患者的死亡风险：一项前瞻性队列研究
Hao Yu,Xinyi Liu,Xueni Cheng et al.
Hao Yu et al.
This study aimed to evaluate the association of a healthy lifestyle pattern with mortality risk among patients with type 2 diabetes mellitus (T2DM). Data were derived from a prospective cohort enrolling 13,776 Chinese patients with T2DM. A ...
RAF1 in AgRP neurons involved in the regulation of energy metabolism via the MAPK signaling pathway [0.03%]
RAF1通过MAPK信号通路参与调控下丘脑AgRP神经元的能量代谢
Yuqian Chen,Lianci Ren,Xinyi Xu et al.
Yuqian Chen et al.
V-raf-leukemia viral oncogene 1(RAF1), a serine/threonine protein kinase, is universally acknowledged to play a crucial role in tumorigenesis and cell development. However, the specific role of hypothalamic RAF1 in regulating energy metabol...
Monocyte to HDL cholesterol ratio predicts obesity-associated cardiac dysfunction [0.03%]
单核细胞与高密度脂蛋白胆固醇比率可预测肥胖相关心脏功能障碍
Chunsheng Zhao,Jinting Liu,Jiaqi Zhao et al.
Chunsheng Zhao et al.
As prevalence of obesity increases dramatically, obesity-associated cardiac dysfunction constitutes a huge challenge to human health. This study aims to find more useful lipid/inflammatory markers to predict the risk of obesity-associated c...
The effect and toxicity profile of consolidative or salvage thoracic radiotherapy following chemoimmunotherapy in patients with extensive stage small cell lung cancer [0.03%]
广泛期小细胞肺癌化疗免疫治疗后巩固或补救性胸部放疗的效果及毒性谱特征分析
Ruo-Zhou Sun,Dan Zong,Xin Chen et al.
Ruo-Zhou Sun et al.
This study evaluated the efficacy and safety of thoracic radiotherapy (TRT) after first-line chemotherapy or chemoimmunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), focusing on the impact of different TRT timin...