DEC1 mediates IL-6-induced EMT in CRC via PI3K/AKT/NF-κB activation [0.03%]
DEC1介导通过PI3K/AKT/NF-κB激活的IL-6诱导的结直肠癌上皮间质转化
Enfang Shan,Weifeng Du,Ziheng Zhang et al.
Enfang Shan et al.
Colorectal cancer (CRC) represents a leading global malignancy. This study investigated the role of differentiated embryonic chondrocyte expressed gene 1 (DEC1) in interleukin-6 (IL-6)-induced invasion and migration of CRC. In vitro, IL-6 u...
Low bone mineral density and handgrip strength are associated with increased risk of all-cause mortality: A cohort study with primary analysis and replication in 16,282 adults [0.03%]
低骨矿物质密度和握力与全因死亡率增加的风险相关：一项含16282名成人队列研究及验证研究
Xinyi Huang,Ningli Han,Kai Ling et al.
Xinyi Huang et al.
This study aimed to evaluate the modifying effects and joint associations of handgrip strength (HGS) and bone mineral density (BMD) with all-cause mortality, with an exploratory analysis of cardiovascular disease (CVD) mortality. A primary ...
Wang Wan,ZhuoHong Ye,GuoXiong Zeng et al.
Wang Wan et al.
Editorial Board
Editorial Board
Engineered extracellular vesicles for targeted TREX1 delivery attenuate neuroinflammation after cerebral ischemia [0.03%]
脑缺血后减轻神经炎症的工程外泌体靶向递送TREX1
Xiaorui Lei,Xinrong Lv,Yiran Wang et al.
Xiaorui Lei et al.
Ischemic stroke stands as a principal driver of global mortality and permanent functional deficits. Notably, the clinical efficacy of current interventions is severely restricted by post-ischemic neuroinflammation. Cerebral ischemic injury ...
The immunological landscape of viral infections in asthma: mechanistic insights and therapeutic paradigm shifts [0.03%]
哮喘病毒感染的免疫特征：机制研究和治疗策略的改变
Juntong Liu,Xinyue Han,Nan Lu et al.
Juntong Liu et al.
Asthma is a common chronic respiratory disease in which respiratory viral infections-particularly rhinoviruses-are closely intertwined with disease manifestations. Such infections contribute substantially to pediatric asthma episodes and to...
The single-cell atlas of programmed cell death signature: A machine learning-based prognostic framework in breast cancer [0.03%]
基于机器学习的乳腺癌预后框架：程序性细胞死亡标志单细胞图谱
Jixuan Jiang,Yiwen Wang,Yuju Huang et al.
Jixuan Jiang et al.
Breast cancer remains a leading cause of cancer-related mortality in women, and current prognostic models are suboptimal. The transcriptomic role of programmed cell death (PCD) in breast cancer progression is not fully understood. Here, we ...
Cardiac xenotransplantation: Progress, barriers, and pathways toward clinical translation [0.03%]
心脏异种移植：进展、障碍及临床转化路径
Shangxuan Li,Yi Wang,Dongsheng He et al.
Shangxuan Li et al.
Cardiac xenotransplantation (CXTx) has emerged as a potentially transformative solution to the global shortage of donor organs, driven by recent breakthroughs in genome-editing technologies. This review provides a comprehensive overview of ...
Allogeneic CAR-T cell therapies: Overcoming clinical challenges and therapeutic potential against tumors [0.03%]
同种异体CAR-T细胞疗法：克服临床挑战及治疗潜力
Raniya Khadiullina,Aigul Valiullina,Elvina Gilyazova et al.
Raniya Khadiullina et al.
Chimeric antigen receptor T-cell (CAR-T) therapy represents a major advance in cellular immunotherapy and has demonstrated substantial clinical benefit in relapsed or refractory B-cell malignancies. However, autologous CAR-T therapy remains...
Surface electromyography for evaluating the impact of focused ultrasound on the sciatic nerve modulation in rats [0.03%]
表面肌电图评估聚焦超声波对大鼠坐骨神经调制影响的效果
Zongqi Tu,Xingchao Wang,Yufeng Zhou
Zongqi Tu