Super-resolution live imaging reveals spatiotemporal uncoupling of mitochondria-ER contacts and mitochondrial fission in stem cell aging [0.03%]
超分辨率活体成像揭示了在干细胞衰老过程中线粒体-内质网接触和线粒体分裂的时空解偶联现象
Tianling Cao,Quan Meng,Tiantian Sun et al.
Tianling Cao et al.
O-GlcNAc clusters in intrinsically disordered regions regulate transcriptional condensates and gene control [0.03%]
固有无序区域中的O-GlcNAc聚簇调控转录凝聚物和基因表达调控
Guojian Shao,Qidong Deng,Tianyu Wang et al.
Guojian Shao et al.
Post-translational modifications (PTMs) dynamically regulate the liquid-liquid phase separation (LLPS) that organizes biomolecular condensates, yet for the monosaccharide O-linked β-N-acetylglucosamine (O-GlcNAc) modification, the general ...
CRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence [0.03%]
运用CRISPR筛选技术鉴定出GNPTAB是非典性STING激活因子诱导细胞衰老的驱动因素
Jian Yin,Yizhou Gao,Yaobin Jing et al.
Jian Yin et al.
Cellular senescence is accompanied by profound lysosomal alterations, yet whether lysosome-associated factors actively drive aging remains unclear. Through a focused CRISPR/Cas9 screen in human mesenchymal progenitor cells (hMPCs), we ident...
Chaf1a is required for cardiomyocyte karyokinesis and cardiac endowment [0.03%]
Chafr1a对心肌细胞核分裂和心脏赋形是必需的
Zhaohui Ouyang,Min Yuan,Rongrong Huang et al.
Zhaohui Ouyang et al.
Shared CRISPR arrays underpin type I-A/I-B coexistence [0.03%]
共存的I-A和I-B型CRISPR阵列背后的共享CRISPR spacer数组
Kunming Liu,Chunjiang Ren,Xinyue Liu et al.
Kunming Liu et al.
CRISPR-Cas systems provide adaptive immunity in prokaryotes, yet how multiple CRISPR-Cas subtypes coexist and coordinate within a single genome remains unclear. Comparative genomic analysis revealed that nearly one-third of type I-A CRISPR-...
Protein and pedagogy: the person behind the indigenization of biochemistry in China [0.03%]
蛋白质与教学法：推动中国生物化学本土化发展的那个人
Quanxiu Li,Cheng Zhen
Quanxiu Li
Lin Fu,Hongsheng Lu,Ruhong Li et al.
Lin Fu et al.
Lipid droplets (LDs) are intracellular organelles that dynamically regulate lipid and energy homeostasis, mediate hormone production, produce inflammation signaling, while also participating in numerous biological processes and activities. ...
Astragalus membranaceus Ameliorates Endometrial Aging and Restores Receptivity by Enhancing Mitochondrial Function in Stromal and Epithelial Cells [0.03%]
膜荚黄芪通过增强内膜间质和上皮细胞线粒体功能改善子宫内膜抗衰老及容受性障碍的作用机制及其互作网络毒性效应研究
Xiunan Chen,Hongjuan Niu,Feng Deng et al.
Xiunan Chen et al.
African swine fever virus MGF_110-3L and MGF_110-4L signal TLR2-mediated lethal inflammation [0.03%]
非洲猪瘟病毒MGF_110-3L和MGF_110-4L诱发TLR2介导的致死性炎症反应
Yue Wang,Tian Xia,Yu Huan Shao et al.
Yue Wang et al.
African swine fever virus (ASFV) is a lethal pathogen that triggers uncontrolled cytokine storms and severe immunopathology. However, the viral factors responsible for systemic inflammation remain unclear. Here, we show that the ASFV-encode...
Designed nanoparticles enable multivalent display of influenza HA to drive rapid, potent, durable, and cross-reactive antibody responses [0.03%]
设计的纳米颗粒能够实现流感HA多价展示以驱动快速、有力、持久及交叉反应性的抗体免疫响应
Pan Liu,Yongyi Xi,Jiali Deng et al.
Pan Liu et al.