Massive GGAAs in genomic repetitive sequences serve as a nuclear reservoir of NF-κB [0.03%]
基因组重复序列中的大量GGAAs充当NF-κB的核库
Jian Wu,Qiao Wang,Wei Dai et al.
Jian Wu et al.
Nuclear factor κB (NF-κB) is a DNA-binding transcription factor. Characterizing its genomic binding sites is crucial for understanding its gene regulatory function and mechanism in cells. This study characterized the binding sites of NF-...
DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1 [0.03%]
DNA甲基化介导的miR-181a/135a/302c表达抑制通过靶向PLAG1促进微卫星不稳定型结直肠癌的发生及氟尿嘧啶耐药性
Lu Shi,Xiang Li,Zhiqiang Wu et al.
Lu Shi et al.
Microsatellite instability (MSI) defines a subtype of colorectal cancer (CRC) with typical clinicopathologic characteristics. CRCs with MSI (MSI CRCs) frequently acquire accelerated carcinogenesis and 5-FU resistance, and the exact underlyi...
Optimized Target-AID system efficiently induces single base changes in zebrafish [0.03%]
优化的靶向AID系统可有效诱导斑马鱼单碱基变化
Xiaochan Lu,Yunxing Liu,Guanrong Yan et al.
Xiaochan Lu et al.
Hu Zeng,Bo He,Chengqi Yi et al.
Hu Zeng et al.
Analysis of patient's materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potential for numerous diagnosti...
Dongsheng Chen,Shuang Wang,Xiaoqian Tao et al.
Dongsheng Chen et al.
The N6-adenine methylation in yeast genome profiled by single-molecule technology [0.03%]
单分子测序绘制酵母基因组N6-腺嘌呤甲基化图谱
Zhe Liang,Guoliang Yu,Jingrong Liu et al.
Zhe Liang et al.
Novel DYW-type pentatricopeptide repeat (PPR) protein BLX controls mitochondrial RNA editing and splicing essential for early seed development of Arabidopsis [0.03%]
新型DYW型五肽重复(PPR)蛋白BLX调控拟南芥早期种子发育必需的线粒体RNA编辑和剪接
Yan Sun,Jiaying Huang,Sheng Zhong et al.
Yan Sun et al.
In plants, RNA editing is a post-transcriptional process that changes specific cytidine to uridine in both mitochondria and plastids. Most pentatricopeptide repeat (PPR) proteins are involved in organelle RNA editing by recognizing specific...
The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury [0.03%]
去SUMO化酶特异性SENTRIN蛋白酶3参与心肌缺血再灌注损伤
Lingchen Gao,Yichao Zhao,Jie He et al.
Lingchen Gao et al.
Sentrin-specific protease 3 (SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion (MIR) injury i...
A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c [0.03%]
新型长链非编码RNA Lnc-OC1通过吸附miR-34a和miR-34c促进卵巢癌细胞增殖和转移
Fangfang Tao,Xinxin Tian,Mengxi Lu et al.
Fangfang Tao et al.
Long non-coding RNAs (lncRNAs) have been reported to be of great importance in tumorigenesis and progression of a variety of cancers. However, the role of lncRNAs in ovarian cancer (OC) remains largely unknown. In the present study, we iden...