Functional non-homologous end joining patterns triggered by CRISPR/Cas9 in human cells [0.03%]
人类细胞中由CRISPR / Cas9触发的功能性非同源末端连接模式
Fayu Yang,Xianglian Ge,Xiubin He et al.
Fayu Yang et al.
Generation of rat-mouse chimeras by introducing single cells of rat inner cell masses into mouse blastocysts [0.03%]
通过将单个大鼠内细胞群移入小鼠囊胚产生嵌合体rats
Tianda Li,Leyun Wang,Xinxin Zhang et al.
Tianda Li et al.
The caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish [0.03%]
斑马鱼尾背主动脉通过内皮-血岛转化产生造血干细胞和祖细胞
Yandong Zhan,Youkui Huang,Jingying Chen et al.
Yandong Zhan et al.
Zebrafish hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium of the ventral wall of the dorsal aorta (DA) through the endothelial-to-hematopoietic transition (EHT) from approximately 30 to 60 hours post...
Validation of the diagnostic potential of mtDNA copy number derived from whole genome sequencing [0.03%]
全基因组测序衍生的线粒体DNA拷贝数的诊断能力验证
Rachel Brockhage,Jesse Slone,Zeqiang Ma et al.
Rachel Brockhage et al.
Whole-genome RNAi screen identifies methylation-related genes influencing lipid metabolism in Caenorhabditis elegans [0.03%]
利用秀丽隐杆线虫进行全基因组RNA干扰筛选寻找影响脂质代谢的甲基化相关基因
Xiaotong Zhu,Yangli Liu,Hong Zhang et al.
Xiaotong Zhu et al.
Lipid droplets (LDs) are highly conserved multifunctional cellular organelles and aberrant lipid storage in LDs can lead to many metabolic diseases. However, the molecular mechanisms governing lipid dynamic changes remain elusive, and the h...
Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease [0.03%]
SMO信号减弱可缓解阿尔茨海默病动物模型中的Aβ诱导的记忆力下降和神经元炎症
Weiwei Ma,Mengnan Wu,Siyan Zhou et al.
Weiwei Ma et al.
Emerging evidence suggests that neuro-inflammation begins early and drives the pathogenesis of Alzheimer's disease (AD), and anti-inflammatory therapies are under clinical development. However, several anti-inflammatory compounds failed to ...
Yeast KEOPS complex regulates telomere length independently of its t6A modification function [0.03%]
酿酒酵母KEOPS复合物独立于其t6A甲基化功能调控端粒长度
Ying-Ying Liu,Ming-Hong He,Jia-Cheng Liu et al.
Ying-Ying Liu et al.
In Saccharomyces cerevisiae, the highly conserved Sua5 and KEOPS complex (including five subunits Kae1, Bud32, Cgi121, Pcc1 and Gon7) catalyze a universal tRNA modification, namely N6-threonylcarbamoyladenosine (t6A), and regulate telomere ...
Lei Qiu,Xiaoyan Hu,Qian Jing et al.
Lei Qiu et al.
Oncohistones are histones with high-frequency point mutations that are associated with tumorigenesis. Although each histone variant is encoded by multiple genes, a single mutation in one allele of one gene seems to have a dominant effect ov...
CRISPR/Cas9-edited Pax6-GFP reporter system facilitates the generation of mouse neural progenitor cells during differentiation [0.03%]
CRISPR/Cas9打靶的Pax6-GFP报告系统可有效追踪小鼠神经干细胞分化过程中的转录因子表达
Yanni Li,Xu Li,Haisong Wang et al.
Yanni Li et al.
Yi-Chun Huang,Henry Moreno,Sarayu Row et al.
Yi-Chun Huang et al.