Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands [0.03%]
Zfhx3是促进小鼠乳腺导管侧支生成和腺泡生成的孕酮/孕酮受体信号传导所必需的
Gui Ma,Ang Gao,Yinan Yang et al.
Gui Ma et al.
Progesterone (Pg)/progesterone receptor (PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be clarified. Using in vitro and in vivo models and histolog...
CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice [0.03%]
CPI-17介导的血管平滑肌收缩在肥胖小鼠高血压发病机制中的作用不可或缺
Jie Sun,Tao Tao,Wei Zhao et al.
Jie Sun et al.
Several factors have been implicated in obesity-related hypertension, but the genesis of the hypertension is largely unknown. In this study, we found a significantly upregulated expression of CPI-17 (C-kinase-potentiated protein phosphatase...
IBM1-dependent H3K9 demethylation enables self-silencing of an exogenous silencer for the non-cell autonomous silencing of an endogenous target gene [0.03%]
IBM1依赖的H3K9去甲基化可使外源基因沉默子自身失活并进而沉默内源目标基因
Xiaolan Liu,Jianhua Zhao,Hui-Shan Guo
Xiaolan Liu
Guoling Li,Xianwei Zhang,Hao Ou et al.
Guoling Li et al.
SAA-Cas9: A tunable genome editing system with increased bio-safety and reduced off-target effects [0.03%]
可调的基因组编辑系统具有更高的生物安全性和减少的脱靶效应(SAA-Cas9)
Sanyuan Ma,Jianduo Zhang,Wei Lu et al.
Sanyuan Ma et al.
Control of de novo root regeneration efficiency by developmental status of Arabidopsis leaf explants [0.03%]
拟南芥叶片脱分化的发育状态控制不定根再生效率
Jing Pan,Fei Zhao,Guifang Zhang et al.
Jing Pan et al.
De novo root regeneration (DNRR) has wide applications in agriculture such as those related to cutting technology. Detached Arabidopsis thaliana leaf explants can regenerate adventitious roots without added hormones. The regenerative abilit...
The genome-wide landscape of small insertion and deletion mutations in Monopterus albus [0.03%]
中国团头鲂全基因组中小规模插入和缺失遗传变异图谱分析
Feng Chen,Fengling Lai,Majing Luo et al.
Feng Chen et al.
Insertion and deletion (indel) mutations, which can trigger single nucleotide substitutions on the flanking regions of genes, may generate abundant materials for disease defense, reproduction, species survival and evolution. However, geneti...
Targeted knockout of duox causes defects in zebrafish growth, thyroid development, and social interaction [0.03%]
Duox靶向敲除导致斑马鱼生长、甲状腺发育和社交行为缺陷
Jong-Su Park,Tae-Ik Choi,Oc-Hee Kim et al.
Jong-Su Park et al.
Zhe Sun,Ji-Long Liu
Zhe Sun
CTP synthase (CTPS), the rate-limiting enzyme in de novo CTP biosynthesis, has been demonstrated to assemble into evolutionarily conserved filamentous structures, termed cytoophidia, in Drosophila, bacteria, yeast and mammalian cells. Howev...
Artificial selection drives differential gene expression during pig domestication [0.03%]
人工选择驱动家猪 Domestication过程中基因表达的差异性变化
Yang Yang,Chaorui Liu,Adeniyi C Adeola et al.
Yang Yang et al.