Embryonic lineage tracing with Procr-CreER marks balanced hematopoietic stem cell fate during entire mouse lifespan [0.03%]
Procr-CreER胚胎谱系示踪标记了整个生命期小鼠平衡的造血干细胞命运
Xiaona Zheng,Guangyu Zhang,Yandong Gong et al.
Xiaona Zheng et al.
The functional heterogeneity of hematopoietic stem cells (HSCs) has been comprehensively investigated by single-cell transplantation assay. However, the heterogeneity regarding their physiological contribution remains an open question, espe...
Acquisition of functional neurons by direct conversion: Switching the developmental clock directly [0.03%]
功能神经元的直接转换获取：直接拨动发育时钟
Shuangquan Chen,Juan Zhang,Dongming Zhang et al.
Shuangquan Chen et al.
Identifying approaches for treating neurodegeneration is a thorny task but is important for a growing number of patients. Researchers have focused on discovering the underlying molecular mechanisms of reprogramming and optimizing the techno...
Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I [0.03%]
鸡的进化选择保留了MDA5和LGP2在没有RIG-I的情况下保持抗病毒活性
Ling Xu,Dandan Yu,Yu Fan et al.
Ling Xu et al.
Rapid breeding of pink-fruited tomato hybrids using the CRISPR/Cas9 system [0.03%]
利用CRISPR/Cas9系统快速培育粉色番茄杂交种
Tianxia Yang,Lei Deng,Wei Zhao et al.
Tianxia Yang et al.
Identification of transcriptional isoforms associated with survival in cancer patient [0.03%]
鉴定与癌症患者生存相关转录异构体的方法
Zefang Tang,Tianxiang Chen,Xianwen Ren et al.
Zefang Tang et al.
The Cancer Genome Atlas (TCGA) project produced RNA-Seq data for tens of thousands of cancer and non-cancer samples with clinical survival information, providing an unprecedented opportunity for analyzing prognostic genes and their isoforms...
The p.(Pro170Leu) variant in NOG impairs noggin secretion and causes autosomal dominant congenital conductive hearing loss due to stapes ankylosis [0.03%]
NOG基因的p.(Pro170Leu)变异导致骨迷路中锤骨与前庭窗融合并引起先天性传导性耳聋的新机制研究
Yilai Shu,Lijun Wang,Xiaoting Cheng et al.
Yilai Shu et al.
Temperature-sensitive cytoophidium assembly in Schizosaccharomyces pombe [0.03%]
模式生物粟酒裂殖酵母中的温度敏感性细胞骨架聚集现象研究
Jing Zhang,Ji-Long Liu
Jing Zhang
The metabolic enzyme CTP synthase (CTPS) is able to compartmentalize into filaments, termed cytoophidia, in a variety of organisms including bacteria, budding yeast, fission yeast, fruit flies and mammals. A previous study in budding yeast ...
Examining the practical limits of batch effect-correction algorithms: When should you care about batch effects? [0.03%]
检验批量效应矫正算法的实际限制:何时应关心批量效应？
Longjian Zhou,Andrew Chi-Hau Sue,Wilson Wen Bin Goh
Longjian Zhou
Batch effects are technical sources of variation and can confound analysis. While many performance ranking exercises have been conducted to establish the best batch effect-correction algorithm (BECA), we hold the viewpoint that the notion o...
SERCA regulates collective cell migration by maintaining cytoplasmic Ca2+ homeostasis [0.03%]
SERCA通过维持细胞质钙稳态来调节集体细胞迁移
Xuan Guo,Jun Luo,Heng Wang et al.
Xuan Guo et al.
A highly efficient in vivo plasmid editing tool based on CRISPR-Cas12a and phage λ Red recombineering [0.03%]
基于CRISPR-Cas12a和λ红噬菌体重组工程的高效体内质粒编辑工具
Yiman Geng,Haiqin Yan,Pei Li et al.
Yiman Geng et al.