Massively parallel characterization of non-coding de novo mutations in autism spectrum disorder [0.03%]
自闭症光谱障碍中非编码从头突变的大规模并行表征
Congcong Chen,Songwei Guo,Yanan Shi et al.
Congcong Chen et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder where de novo mutations play a significant role. Although coding mutations in ASD have been extensively characterized, the impact of non-coding de novo mutations (ncDNMs) remai...
Xuping Zhou,Tao Peng,Jin Yu et al.
Xuping Zhou et al.
Postnatal critical-period brain plasticity and neurodevelopmental disorders: revisited circuit mechanisms [0.03%]
产后关键期大脑可塑性和神经发育障碍：重新审视电路机制
Ziwei Shang,Xiaohui Zhang
Ziwei Shang
Critical periods (CPs) are defined as postnatal developmental windows during which brain circuits exhibit heightened sensitivity to altered experiences or sensory inputs, particularly during brain development in humans and animals. During t...
Jasmonate signaling: integrating stress responses with developmental regulation in plants [0.03%]
茉莉酸信号转导：整合植物胁迫响应与发育调控
Yanbing Li,Fangming Wu,Chuanyou Li
Yanbing Li
Jasmonates (JAs) are essential phytohormones that coordinate plant defense and development in response to unpredictable environments. Recent scientific advances have highlighted the SCFCOI1-JAZ-MYC2-MED25 module as a central hub for JA sign...
Whole-genome sequencing provides insights into the evolutionary adaptation and conservation of gibbons [0.03%]
全基因组测序揭示了白眉长臂猿的进化适应和种群动态
Wang Guiqiang,Wu Yajiang,Wang Song et al.
Wang Guiqiang et al.
Gibbons are small, arboreal apes that play a critical role in tropical biodiversity and ecosystem ecology. However, nearly all species of gibbons are threatened by habitat loss, illegal trade, hunting, and other human activities. Long-term ...
Receptor-like protein 51 regulates brassinosteroid signaling by promoting the abundances of BRI1 and BAK1 [0.03%]
受体类似蛋白51通过促进BRI1和BAK1的丰度来调节 brassinosteroid信号转导
Yuan Fang,Pengcheng Li,Bingqing Tao et al.
Yuan Fang et al.
Brassinosteroids (BRs) are essential phytohormones that broadly regulate plant growth, development, and adaptation to biotic and abiotic stresses. In Arabidopsis, apoplastic BR molecules are perceived by a plasma membrane-localized receptor...
Genetic landscape of hereditary cardiomyopathies and arrhythmias in China [0.03%]
中国遗传性心肌病和心律失常的基因组景观
Yang Lu,Zeyuan Wang,Shuyuan Zhang et al.
Yang Lu et al.
Hereditary cardiomyopathies and arrhythmias are major contributors to cardiovascular morbidity and mortality. The advent of next-generation sequencing (NGS) has made genetic testing more accessible, which is crucial for precise diagnosis an...
PHYTOCHROME-INTERACTING FACTOR3 (PIF3) orthologs orchestrate stem elongation and wood formation in Populus [0.03%]
拟南芥PHYTOCHROME-INTERACTING FACTOR3（PIF3）直向同源基因协调杨树的茎伸长和木质部形成
Xingyue Xiao,Hongli Cheng,Jianghai Mo et al.
Xingyue Xiao et al.
Phytochrome-interacting factors (PIFs) have been established as negative regulators of vascular patterning and xylem differentiation in the herbaceous plant Arabidopsis thaliana, however, PIFs' regulatory role in secondary growth in woody s...
PenCards: a global and community-contributed public archive of variant penetrance [0.03%]
PenCards：全球且社区贡献的变异渗透公共档案
Zhaopo Zhu,Ling Shang,Chuhan Shao et al.
Zhaopo Zhu et al.
Penetrance is a crucial indicator for accurately assessing disease risk and plays a vital role in disease research, gene therapy, and genetic counseling. However, with penetrance data dispersed across various sources, efficiently accessing ...
USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation [0.03%]
USP21通过去泛素化DPYSL2促进其在中心体的积累从而正向调控纤毛形成
Ting Song,Peng Zhou,Fengguo Zhang et al.
Ting Song et al.
Cilia are microtubule-based organelles projecting from the cell surface with important sensory and motility functions. Ciliary defects are associated with diverse diseases collectively known as ciliopathies. However, the molecular mechanism...