Mov10 mitigates hematopoietic stem cell exhaustion under stress by modulating the Camp-mediated inflammatory pathway [0.03%]
Mov10通过调节Camp介导的炎症通路缓解应激下的造血干细胞耗竭
Changlin Zhen,Junbing Pan,Wei Wang et al.
Changlin Zhen et al.
The integrity of hematopoietic stem cell (HSC) function is crucial for robust hematopoietic regeneration following stress. Inflammatory responses are pivotal drivers of HSC stress response, yet the precise modulation of inflammatory pathway...
Multi-omics identification and verification of Dnajb14 as a modulator of retinal ganglion cell survival in glaucoma through ferroptosis [0.03%]
多组学识别和验证Dnajb14通过铁死亡调节青光眼中的视网膜神经节细胞存活
Yu Chen,Jie Wen,Qian Yang et al.
Yu Chen et al.
Glaucoma is a leading cause of irreversible blindness and necessitates the identification of unreported therapeutic targets. Here, we report eight stable plasma protein targets for glaucoma, identified through a large-scale proteome-wide as...
Membrane depolarization drives tumor-suppressive cell competition via Hedgehog signaling activation [0.03%]
膜去极化通过激活 hedgehog 信号通路驱动抑癌细胞竞争
Kun Zhao,Dian Lv,Du Kong et al.
Kun Zhao et al.
Tumor-suppressive cell competition (TSCC) is an evolutionarily conserved process that safeguards tissue integrity by selectively eliminating less-fit, precancerous cells. While bioelectric regulation via plasma membrane potential (Vm) is em...
Metabolic reprogramming of sucrose flux boosts natural rubber in Taraxacum kok-saghyz [0.03%]
糖代谢重构促进俄罗斯蒲公英天然橡胶生物合成
Xiuli Fan,Qingwen Chen,Xiaoguang Song et al.
Xiuli Fan et al.
Zhenfu Li,Wenjing Zhang,Yuxin Wu et al.
Zhenfu Li et al.
Stem cells reside in specific microenvironments where they divide to maintain themselves and differentiate into functional cells that replace old, dead, or damaged cells to maintain tissue homeostasis. Some stem cells could also be cultured...
Genetic dissection of cadmium accumulation in tea plants under nonphytotoxic field conditions [0.03%]
在非毒力田间条件下对茶树镉积累进行遗传剖析
Shijie Luo,Xinwan Zhang,Weiyi Zhang et al.
Shijie Luo et al.
Cadmium (Cd) accumulation in tea plants (Camellia sinensis) under chronic, nonphytotoxic field conditions poses a persistent food safety challenge; however, the genetic basis of this process remains uncharacterized. To dissect the genetic a...
Molecular basis of blade-pseudo-petiole-sheath axis patterning in Spodiopogon sagittifolius: roles of auxin signaling and lineage-specific regulators [0.03%]
具剑形叶变叶莫草叶片-假叶柄-叶鞘成轴模式的分子机制：生长素信号与谱系特异性因子的作用
Chao Xu,Yang Wang,Liping Qin et al.
Chao Xu et al.
Single-cell multiomics gene regulatory landscape reveals impaired spermatogonial stem cells and macrophage-driven inflammaging during testicular aging [0.03%]
单细胞多组学基因调控网络揭示了生精干细胞缺陷及睾丸衰老过程中巨噬细胞驱动的炎症老化现象
Nanhe Lin,Zhiqiang Zhang,Xianshen Sha et al.
Nanhe Lin et al.
Testicular aging is a key driver of declining male reproductive health, but a comprehensive understanding of its underlying epigenetic drivers is lacking. To address this, we construct a multiomics aging atlas by integrating single-cell RNA...
Decoding chromosome organization using proximity labeling and long-read sequencing [0.03%]
基于邻近标记和长读测序技术解析染色体高级结构
Kewei Xu,Yichen Zhang,James Baldwin-Brown et al.
Kewei Xu et al.
Genomic approaches have provided detailed insight into DNA-protein interactions and chromosome architecture. However, commonly deployed techniques do not preserve connectivity-based information, leaving large-scale genome organization poorl...
Non-redundant functions of three CRM proteins in mitochondrial group II intron splicing and maize seed development [0.03%]
三个CRM蛋白在叶绿体和线粒体二类内含子剪接及玉米种子发育中的非冗余功能
Yingbo Li,Mingyue Zhang,Yuhong Wei et al.
Yingbo Li et al.
Group II introns are abundant in plant mitochondrial genomes and require numerous nuclear-encoded RNA-binding proteins for their splicing. Chloroplast RNA splicing and ribosome maturation (CRM) proteins constitute an evolutionarily conserve...