Genome of aerial alga Trentepohlia odorata reveals insights into the evolution of terrestrial lifestyle in green algae [0.03%]
气生蓝藻Trentepohlia odorata基因组揭示了绿藻向陆地生活方式进化中的见解
Yuanhao Li,Jiao Fang,Xiaoya Ma et al.
Yuanhao Li et al.
Trentepohliales is a completely terrestrial order within Ulvophyceae (the core Chlorophyta), and its closely related lineages are mainly marine macroalgae (green seaweeds). Despite the considerable interest in their biotechnological potenti...
The application and prospects of spatial omics technologies in clinical medical research and molecular diagnostics [0.03%]
空间组学技术在临床医学研究和分子诊断中的应用与展望
Xiaofeng Wu,Weize Xu,Da Lin et al.
Xiaofeng Wu et al.
While conventional FISH and IHC methods struggle to decode complex tissue heterogeneity and comprehensive molecular diagnosis due to low-throughput spatial information, spatial omics technologies enable high-throughput molecular mapping acr...
Genomic sequencing as a key primary recommendation for neonatal hyperbilirubinemia: a population-based multicenter study [0.03%]
基于人群的多中心研究显示基因组测序可作为新生儿高胆红素血症的一线推荐手段
Dabin Huang,Xia Gu,Weizhong Li et al.
Dabin Huang et al.
Genetic variations are risk factors for neonatal hyperbilirubinemia (NHB), a common cause of infant hospitalization in the first postnatal week, but their contribution and long-term impacts remain unclear. This population-based multicenter ...
Integrative multi-omics and genomic prediction reveal genetic basis of early salt tolerance in alfalfa [0.03%]
整合多组学和基因组预测揭示盐地百慕大草早期耐盐性的遗传基础
Fei He,Ming Xu,Ruicai Long et al.
Fei He et al.
The genetic basis of early-stage salt tolerance in alfalfa (Medicago sativa L.), a key factor limiting its productivity, remains poorly understand. To dissect this complex trait, we integrate genome-wide association study (GWAS) and transcr...
Deciphering the genetic regulation of flowering time in rapeseed for early-maturation breeding [0.03%]
破译油菜开花期遗传调控网络以促进早熟育种
Minghao Zhang,Wei Chang,Ruicheng Hu et al.
Minghao Zhang et al.
Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptability of rapeseed (Brassica napus L.). Strategically advancing flowering time can reduce the risk of yield losses due to extreme climatic con...
ATPase-deficient CHD7 disease variant disrupts neural development via chromatin dysregulation [0.03%]
无ATP酶活性的CHD7疾病变异通过染色质调控障碍干扰神经发育
Guangfu Wang,Zhuxi Huang,Chenxi He et al.
Guangfu Wang et al.
Chromodomain helicase DNA binding protein 7 (CHD7), an ATP-dependent chromatin remodeler, plays versatile roles in neurodevelopment. However, the functional significance of its ATPase/nucleosome remodeling activity remains incompletely unde...
Xiaoyue Du,Xiaoxi Zhang,Jiucun Wang et al.
Xiaoyue Du et al.
Recent advancements in genome sequencing have enabled the estimation of genetic load through deleterious mutation profiling. However, Chinese populations remain underexplored in this context. We analyze whole-exome sequencing data from 5002...
Rapamycin alleviates neurodegeneration in a Drosophila model of spinocerebellar ataxia type 51 [0.03%]
雷帕霉素能缓解脊髓小脑共济失调5型果蝇模型中的神经退行性病变
Cuijie Wei,Taoyun Ji,Jin Xu et al.
Cuijie Wei et al.
Spinocerebellar ataxia (SCA) type 51 is a neurodegenerative disease caused by CAG repeat expansions in exon 1 of the THAP11 gene. These repeats are translated into a glutamine-rich protein, THAP11-polyQ, which forms protein aggregates and e...
MitoQ alleviates m.3243A>G-induced mitochondrial dysfunction by stabilizing PINK1 and enhancing mitophagy [0.03%]
线粒体靶向抗氧化剂MitoQ通过稳定PINK1蛋白并增强线粒体自噬改善m.3243A>G突变诱导的线粒体功能异常
Baige Cao,Lei Fang,Yinan Zhang et al.
Baige Cao et al.
The mitochondrial 3243A>G mutation (m.3243A>G) is associated with diverse clinical phenotypes. To elucidate the underlying mechanisms and explore intervention strategies in m.3243A>G patients, urine-derived stem cells (USCs) and a mitochond...
The interplay between phosphorus nutrition and abiotic stresses in plants [0.03%]
植物磷营养与非生物胁迫间的互作关系研究进展
Houqing Zeng,Feiyu Chen,Qiuqing Zhu et al.
Houqing Zeng et al.
Phosphorus (P) is an essential macronutrient required for plant growth, development, and resilience to environmental stresses. Its availability in soil and homeostasis within plants are strongly influenced by environmental conditions, with ...