Tissue-resolved comparative developmental transcriptomics reveals auxin-associated regulatory shifts underlying divergent fruit tissue origins in pomes and drupes [0.03%]
组织解析比较发育转录组学揭示了苹果类水果和核果中与生长素相关且起源不同的果实调控机制中的调控变化
Jiakai Liang,Qiaoming Yu,Yan Wang et al.
Jiakai Liang et al.
Fruit type divergence in closely related species offers a powerful lens into the evolution of plant developmental programs. Within the Rosaceae family, pomes (e.g., apple) and drupes (e.g., peach) share a common ancestry but exhibit a funda...
Characterizing selection signatures in coding and noncoding regions of 14,886 cancer genomes [0.03%]
基于14,886例肿瘤基因组的编码区和非编码区选择信号的特征分析
Mengyue Zheng,Xiwei Sun,Junren Hou et al.
Mengyue Zheng et al.
Clonal selection drives cancer development, but quantifying selection on noncoding somatic mutations remains largely unexplored. Here, we introduce dNdS-Fun, an extension of the dN/dS framework to quantify selection of both coding and nonco...
CHST5 gene mutations contribute to high myopia by disrupting collagen fiber organization [0.03%]
CHST5基因突变通过破坏胶原纤维排列而导致高度近视
Meining He,Senwei Tan,Furong Huang et al.
Meining He et al.
High myopia (HM) is a leading cause of irreversible vision loss in working-age adults. Its pathogenesis is characterized by alterations in the microstructure and composition of collagen fibers, and genetic factors make a substantial contrib...
Neuroprotective role of Faecalibacterium prausnitzii-derived butyrate in diabetic gastrointestinal autonomic neuropathy [0.03%]
Faecalibacterium prausnitzii衍生丁酸的糖尿病胃肠自主神经病变神经保护作用
Lin Guo,Jie Li,Jiaming An et al.
Lin Guo et al.
Diabetic gastrointestinal autonomic neuropathy (DGAN) is a common yet poorly understood complication of diabetes that is characterized by gastrointestinal dysmotility and enteric neurodegeneration. Here, we investigate whether gut microbiot...
Divergent roles of the Rag GTPases MoGtr1 and MoGtr2 in TOR signaling, autophagy, and pathogenicity of Magnaporthe oryzae [0.03%]
Magnaporthe oryzae中Rag GTP酶MoGtr1和MoGtr2在TOR信号转导、自噬及致病性中的功能差异分析
Shengjie Zheng,Tian Chen,Wei Cao et al.
Shengjie Zheng et al.
In eukaryotes, conserved Rag-family GTPases are crucial for TOR signaling, integrating nutrient sensing with cellular growth. However, their functions in filamentous fungal pathogens are poorly understood. Here, we demonstrate that MoGtr1 a...
MaWRKY76 enhances symbiotic nodulation and salt tolerance of nodulation by activating NIN in Melilotus albus [0.03%]
牻牛儿牻牛儿素黄酮酶76通过激活黄芪中的NIN增强固氮结节和耐盐性
Shengsheng Wang,Bao Ao,Qi Yan et al.
Shengsheng Wang et al.
Legumes establish mutualistic symbiosis with rhizobia to facilitate biological nitrogen fixation. However, the genetic and molecular mechanisms of symbiotic nodulation regulated by salt stress remain largely unexplored. In this study, we id...
Corrigendum to "Multidisciplinary exploration of ancient atherosclerosis: Paleo-genomic and paleo-nutritional analysis of a 13th century artificial mummy in China" [J. Genet. Genom. (2026) 53, 906-918] [0.03%]
“我国13世纪木乃伊的古基因组和古营养分析——对古代动脉粥样硬化的多学科探索”勘误通知（《遗传》(2026)，53，906-918）
Bangyan Wang,Rui Wang,Duo Zheng et al.
Bangyan Wang et al.
The TNFR2M196R germline variant confers dual impact on CAR-T cell immunotherapy by enhancing T-cell survival and tumor proliferation [0.03%]
TNFR2M196R胚系变异通过增强T细胞存活和肿瘤增殖对CAR-T细胞免疫治疗产生双重影响
Nan Liu,Lu Han,Yuting Lu et al.
Nan Liu et al.
Despite its remarkable efficacy in hematologic malignancies, chimeric antigen receptor T-cell (CAR-T) therapy is often limited by atypical clinical outcomes, necessitating predictive biomarkers. Here, prompted by a patient with low-tumor-bu...
A high-quality genome assembly delineates the genetic basis of freezing tolerance in the elite wheat cultivar Jimai 22 [0.03%]
高质量基因组组装揭示了小麦品种Jimai 22的耐寒遗传基础
Guang Qi,Guangwei Li,Rongzhi Zhang et al.
Guang Qi et al.
LcMADS28 and LcMADS27 coordinately regulate early seed development in Litchi chinensis through direct activation of LcINVERTASE INHIBITOR1 [0.03%]
荔枝LcMADS28和LcMADS27通过直接激活LcINH1协调调控早期种子发育
Lijun Wu,Jun Fang,Jiahui Chen et al.
Lijun Wu et al.
Seed abortion is a critical agronomic trait affecting both fruit quality and yield. Cell wall invertase (CWIN) hydrolyzes sucrose into glucose and fructose, which serve as both nutrients and signaling molecules to regulate seed development,...