Gap-free genome assembly and metabolomics analysis of common bean provide insights into genomic characteristics and metabolic determinants of seed coat pigmentation [0.03%]
常见的蚕豆的无缺口基因组装和代谢组学分析提供了对基因组特征以及种子被色素的代谢决定因素的洞察力
Bo Zhao,Hui Zhang,Qin Zhao et al.
Bo Zhao et al.
Establishing a semi-homology-directed recombination method for precision gene integration in axolotls [0.03%]
建立用于穿山甲精确基因整合的半同源性导向重组方法
Liqun Wang,Yan Hu,Yuanhui Qiu et al.
Liqun Wang et al.
The axolotl is broadly used in regenerative, developmental, and evolutionary biology research. Targeted gene knock-in is crucial for precision transgenesis, enabling disease modeling, visualization, tracking, and functional manipulation of ...
Identification and functional characterization of pathogenic FOXI3 variants in craniofacial microsomia [0.03%]
颅面微小型中致病性FOXI3变异的识别与功能特征分析
Xin Chen,Ying Chen,Chenlong Li et al.
Xin Chen et al.
Genome-wide analysis of Q binding reveals a regulatory network that coordinates wheat grain yield and grain protein content [0.03%]
全基因组Q结合分析揭示了一个协调小麦籽粒产量和籽粒蛋白含量的调控网络
Jing Zhu,Qing Chen,Zhenru Guo et al.
Jing Zhu et al.
Wheat is an important cereal crop used to produce diverse and popular food worldwide because of its high grain yield (GY) and grain protein content (GPC). However, GY and GPC are usually negatively correlated. We previously reported that fa...
The Monochoria genome provides insights into the molecular mechanisms underlying floral heteranthery [0.03%]
雨久花基因组为理解花药异型的分子机制提供了洞见
Jingshan Yang,Jinming Chen,Xiangyan He et al.
Jingshan Yang et al.
Heteranthery, the occurrence of functionally and structurally distinct stamens within a flower, represents a striking example of convergent evolution among diverse animal-pollinated lineages. Although the ecological basis of this somatic po...
GLGW10 controls grain size associated with the lignin content in rice [0.03%]
GLGW10控制与水稻中木质素含量相关的粒径
Haolin Liu,Jinlong Ni,Yuhan Zhang et al.
Haolin Liu et al.
Grain size, which encompasses length, width, and thickness, is a critical agricultural trait that influences both grain yield and quality in rice. Although numerous grain size regulators have been identified, the molecular mechanisms govern...
Amyloid-β oligomers drive amyloid deposit and cascaded tau pathology of Alzheimer's disease in aged brains of non-human primates [0.03%]
淀粉样蛋白寡聚体导致非人灵长类动物老年大脑中阿尔茨海默病的级联tau病理改变
Zhengxiao He,Wenchang Zhang,Ping Chen et al.
Zhengxiao He et al.
Alzheimer's disease (AD), the most prevalent form of dementia, disproportionately affects the elderly population. While aging is widely recognized as a major risk factor for AD, the precise mechanisms by which aging contributes to the patho...
Resolving the spatial and cellular architecture of intra-tumor heterogeneity by multi-region dissection of lung adenocarcinoma [0.03%]
通过肺腺癌多区域解剖解析肿瘤内异质性的空间和细胞结构
Song Mei,Xiaolei Wang,Mengmeng Zhao et al.
Song Mei et al.
Although the spatial characteristics within the tumor microenvironment (TME) of lung adenocarcinoma (LUAD) have been identified, the mechanisms by which these factors promote LUAD progression and immune evasion remain unclear. Using spatial...
Expression quantitative trait loci (eQTL): from population genetics to precision medicine [0.03%]
表达数量性状位点（eQTL）：从群体遗传学至精准医学
Zhi Qi Wong,Lian Deng,Alvin Cengnata et al.
Zhi Qi Wong et al.
Evidence has shown that differential transcriptomic profiles among human populations from diverse ancestries, supporting the role of genetic architecture in regulating gene expression alongside environmental stimuli. Genetic variants that r...
Zongbiao Duan,Liangwei Xu,Guoan Zhou et al.
Zongbiao Duan et al.
Soybean (Glycine max) is a vital foundation of global food security, providing a primary source of high-quality protein and oil for human consumption and animal feed. The rising global population has significantly increased the demand for s...