Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs [0.03%]
过表达显性的负FGFR2-IIIb阻碍猪肺支气管树的形成
Qin Chen,Bin Fang,Ying Wang et al.
Qin Chen et al.
Genetic studies with mouse models have shown that fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb) plays crucial roles in lung development and differentiation. To evaluate the effect of FGFR2-IIIb in pig lung development, we employed s...
Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes [0.03%]
正常成人肝脏的肝细胞源自胚胎肝细胞
Ce Gao,Zhihui Zhu,Yuqi Gao et al.
Ce Gao et al.
Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism [0.03%]
组蛋白乙酰化修饰的跨世代分析构建了表观遗传继承与代谢的关系
Ke An,Fengxia Du,Hao Meng et al.
Ke An et al.
Peng Jin
Peng Jin
AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism [0.03%]
AQR是与2型糖尿病相关的新基因，可调节葡萄糖代谢的关键信号通路
Chun Song,Han Yan,Hanming Wang et al.
Chun Song et al.
Type 2 diabetes mellitus (T2DM) is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using three independent GWAS datasets of T2DM and...
Ling Lu,Junqin Bi,Liming Bao
Ling Lu
Circulating cell-free tumor DNA (ctDNA) in the blood is DNA released from apoptotic, circulating, and living tumor cells. ctDNA is about 140 nt in length and has a half-life of about 1.5 h. ctDNA analysis provides a noninvasive means to ass...
Jesse Slone,Baoheng Gui,Taosheng Huang
Jesse Slone
The mitochondrial organelle is crucial to the energy metabolism of the eukaryotic cell. Defects in mitochondrial function lie at the core of a wide range of disorders, including both rare primary mitochondrial disorders and more common cond...
Jason R Rudman,Christine Mei,Sara E Bressler et al.
Jason R Rudman et al.
Precision medicine (PM) proposes customized medical care based on a patient's unique genome, biomarkers, environment and behaviors. Hearing loss (HL) is the most common sensorineural disorder worldwide and is frequently caused by a single g...