ID3-depleted human induced pluripotent stem cell-derived neural stem/progenitor cells promote neurorepair [0.03%]
ID3缺失的人诱导多能干细胞源神经干细胞/前体细胞促进神经修复
Jia-Di Lin,Ruba Hammad,Prateek Kumar et al.
Jia-Di Lin et al.
Human induced pluripotent stem cell-derived neural stem/progenitor cells are used in cell-replacement and regenerative therapeutic strategies after traumatic central nervous system injury. Traumatic injury alters the host microenvironment, ...
Reactive aldehyde species-mediated neuropathic pain in spinal cord injury: Mechanisms and therapeutic opportunities [0.03%]
脊髓损伤介导的神经性疼痛的反应醛类物质机制及治疗机遇
Rachel L Stingel,Nicholas S Race,Riyi Shi
Rachel L Stingel
Spinal cord injury-related neuropathic pain is difficult to treat and significantly decreases quality of life. Often functionally limiting and refractory to conventional pharmacologic treatments, treating spinal cord injury-related neuropat...
Hypoxia and TTR dysregulation in astrocytes from Parkinson's disease with a specific mitochondrial haplogroup: A single-cell analysis [0.03%]
帕金森病特定线粒体谱系单细胞分析提示星形胶质细胞低氧和TTR失调
Junhao Wang,Wenxuan Du,Xinyi Chen et al.
Junhao Wang et al.
Mitochondrial DNA variants have been linked to cognitive progression in Parkinson's disease; however, the mechanisms by which mitochondrial DNA variants or haplogroups contribute to this process remain unclear. In the present study, we anal...
Polydopamine-coupled NT3-derived oriented conductive scaffolds with immunomodulatory properties accelerate peripheral nerve regeneration [0.03%]
具有免疫调节性能的聚多巴胺连接的NT3导向导电支架加速外周神经再生
Xiaokun Chen,Jihai Xu,Ziyuan Yang et al.
Xiaokun Chen et al.
Peripheral nerve injury is a complex condition presenting significant clinical treatment challenges due to the limited regenerative capacity of peripheral nerves. Nerve conduits have been seen as a promising strategy to overcome the shortag...
Ching-Thong Choo,Chin-Tong Ong
Ching-Thong Choo
Ferroptosis and aging: Inducing and catalyzing neurodegenerative diseases [0.03%]
铁死亡与衰老：诱导并促进神经退行性疾病
Qifeng Song,Shi Sun,Yuxiu Song et al.
Qifeng Song et al.
Ferroptosis is a newly recognized form of programmed cell death characterized by iron overload-dependent lipid peroxidation. These pathological phenomena are often observed in neurodegenerative diseases. Aging is an irreversible process cha...
Reevaluating the role of skeletal muscle in amyotrophic lateral sclerosis pathogenesis: Insights from muscle-derived factors [0.03%]
ALS发病机制中骨骼肌作用的再评估：肌肉来源因子带来的启示
Pablo Martinez,Brigitte van Zundert,Fernando J Bustos
Pablo Martinez
O-GlcNAcylation: A molecular switch linking brain health to neurodegeneration [0.03%]
O-GlcNAc糖基化：连接大脑健康与神经退行性疾病的分子开关
Nan Shao,Xiaoyan Zhang,Yunzhi Ge et al.
Nan Shao et al.
Neurodegenerative disorders are typically caused by harmful protein accumulation and nerve cell damage. A post-translational modification called O-linked N-acetylglucosamine ylation acts as a critical regulator in these disorders by control...
Hevin/sparcl-1 as a potential biomarker and therapy in age-associated cognitive decline [0.03%]
Hevin/sparcL-1可作为年龄相关认知功能下降的生物标志物及治疗靶点
Felipe Cabral-Miranda,Flávia C A Gomes
Felipe Cabral-Miranda