Blood biomarkers for Alzheimer's disease: Key challenges of clinical implementation [0.03%]
阿尔茨海默病的血液生物标志物：临床应用的关键挑战
Rafaela Luiza C Franco,Tai R Hunter,Fernanda G De Felice
Rafaela Luiza C Franco
Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease [0.03%]
工程化过表达miR-146a的间充质干细胞来源外泌体减轻阿尔茨海默病神经炎症反应
Jia Zhang,Siqi He,Qiguo Xiao et al.
Jia Zhang et al.
Alzheimer's disease is an inflammatory neurodegenerative disease for which no effective clinical treatment currently exists. We have previously reported that mesenchymal stem cell.derived extracellular vesicles delay retinal degeneration by...
Gut microbial community of patients with Parkinson's disease analyzed using metagenome-assembled genomes [0.03%]
基于从头组装基因组的帕金森病患者肠道微生物群分析
Yi Zhang,Chengjun Mo,Xiaoqin He et al.
Yi Zhang et al.
Previous investigations into gut microbiota dysbiosis in patients with Parkinson's disease have relied on 16S rRNA amplicon sequencing and assembly-free metagenomic approaches. However, there is an urgent need to study the function of the g...
Genetic and pathway complexity in Alzheimer's disease: Insights from multi-omic data about the immune response and mitochondrial function [0.03%]
阿尔茨海默病的遗传和途径复杂性：关于免疫反应和线粒体功能的多组学数据的新见解
Xuan Xu,Jiang Li,Fei Wang et al.
Xuan Xu et al.
Despite recent developments, the genetics and biology of Alzheimer's disease remain insufficiently characterized. As an important first step toward developing effective treatment strategies to slow or prevent Alzheimer's disease onset, the ...
Steffen Kautzmann,Christian Klämbt
Steffen Kautzmann
Akkermansia muciniphila: A next-generation gut probiotic supporting neurorepair and functional recovery [0.03%]
Akkermansia muciniphila：一种下一代肠道益生菌，支持神经修复和功能恢复
Huiwen Yuan,Jingwei Shi,Chenlong Gu et al.
Huiwen Yuan et al.
The brain-gut axis is a bidirectional signal transduction system between the gastrointestinal tract and the central nervous system that integrates neural, endocrine, and immune functions. In recent years, the role of the intestinal flora in...
Beyond the Barrier: Targeting blood-brain interactions for neuroprotection and repair [0.03%]
超越屏障：靶向血脑相互作用以实现神经保护和修复
Anddre O Valdivia,Caroline Brandt,Mark A Petersen
Anddre O Valdivia
Harnessing synaptic plasticity for sustained motor improvement in Parkinson's disease [0.03%]
利用突触可塑性实现帕金森病的持续运动改善
Srdjan Sumarac,Nader Pouratian,Aryn H Gittis et al.
Srdjan Sumarac et al.
Sho Oasa,Marianne Schultzberg,Lars Terenius
Sho Oasa
Loris Russo,Matilde Cescon
Loris Russo