Time-resolved single-nucleus profiling of inter- and intracellular signaling in optic nerve injury: From the hyperacute phase to the acute phase [0.03%]
光学神经损伤的时序单核分析：从超急阶段到急性阶段的细胞内外信号转导过程
Yi Ding,Wenyue Zhang,Yeli Deng et al.
Yi Ding et al.
Optic nerve injury induces rapid retinal neurodegeneration; however, how distinct retinal cell type responses are coordinated from the hyperacute injury phase to the early repair phase remains incompletely understood. In this study, to expl...
Inhibition of Raly promotes oligodendrocyte precursor cell differentiation and remyelination after chronic hypoperfusion [0.03%]
抑制Raly促进慢性低灌注后少突前体细胞的分化和脱髓鞘组织的再(myelin sheath)化
Zhi Zhang,Xin Shu,Liang Sun et al.
Zhi Zhang et al.
The heterogeneous nuclear ribonucleoprotein-associated protein Raly plays a role in regulating cell proliferation and metabolism in eukaryotic nerve cells. However, the biological significance of Raly in oligodendrocyte lineage progression ...
Synthetic biology-driven bioinspired delivery systems for RNA therapeutics in neural repair [0.03%]
合成生物学驱动的生物启发型RNA药物递送系统促进神经修复
Jie Shen,Chanjuan Qu,Youchao Wang et al.
Jie Shen et al.
RNA therapeutics offer transformative potential for neural repair. However, various delivery challenges continue to hinder the clinical translation of RNA therapeutics. Synthetic biology, as an interdisciplinary cutting-edge field, improves...
Highlighting the mechanisms through which increased dietary folic acid and choline impact regeneration in the brain after damage [0.03%]
叶酸和胆碱摄入量增加对大脑损伤后修复的影响机制解析
Nora Jones,Sumaiya Binte,Nafisa M Jadavji
Nora Jones
Ischemic stroke is a condition caused by an obstruction of blood flow to the brain. Traditionally, there has been a high prevalence in the aged population, but it is increasingly affecting younger adults, reshaping the traditionally underst...
Targeting the type-I interferon response in amyotrophic lateral sclerosis [0.03%]
靶向I型干扰素反应在肌萎缩侧索硬化中的作用
Valeria Gerbino
Valeria Gerbino
Multidimensional roles of acetylcholine receptors in neurobiology and their therapeutic significance [0.03%]
乙酰胆碱受体在神经生物学中的多维度作用及其治疗意义
Yongcai Zhang,Zhenzhen Yu,Wen Luo et al.
Yongcai Zhang et al.
Dysfunction of cholinergic signaling has emerged as a convergent mechanism across neurological and neuromuscular disorders, linking disturbances in synaptic, immune, and metabolic regulation. This review summarizes recent structural, functi...
Functionalized, oriented chitosan-fibrin hydrogel scaffold creating a pro-regenerative microenvironment for peripheral nerve repair [0.03%]
功能化取向壳聚糖-纤维蛋白水凝胶支架建立利于周围神经再生的微环境
Yifan Fang,Yuyang Luo,Jinjin Zhu et al.
Yifan Fang et al.
Biomaterials integrating guidance cues have been developed to modulate microenvironments in situ, demonstrating potential for enhancing neurite growth and motor recovery. However, constructing a dynamically degradable microenvironment that ...
Human induced pluripotent stem cell-derived cortical grafts rebuild motor circuits after brain injury [0.03%]
人诱导性多能干细胞来源的皮层移植细胞可修复脑损伤后的运动环路
Myles D Gladen,Zane R Lybrand
Myles D Gladen
Traumatic brain injury causes irreversible neuronal loss, and no existing therapy can replace lost cortical tissue and restore its circuitry. We investigated whether human induced pluripotent stem cell-derived cortical organoids could not o...
Dopamine, glutamate, and gamma-aminobutyric acid: Key hubs in neurotransmitters, signal transduction, and cognitive dysfunction [0.03%]
多巴胺、谷氨酸和γ-氨基丁酸：神经递质、信号转导和认知功能障碍中的关键节点
Zichao Huang,Yajun Zhu,Xiaoguo Li et al.
Zichao Huang et al.
Neurotransmitters such as dopamine, glutamate, and gamma-aminobutyric acid (GABA) play crucial roles in regulating cognitive functions including learning, memory, and executive control. Dysregulation in synthesis, release, and metabolism of...
New functions for adult neurogenesis in humans: Guideposts for regenerative medicine [0.03%]
成人神经发生的新功能：再生医学的路标指引
Aswathy Ammothumkandy,Michael A Bonaguidi
Aswathy Ammothumkandy