Oligodendrocyte precursor cellneuronal lysosomal pathway: A novel therapeutic target for neurodegenerative diseases [0.03%]
少突前体细胞-神经元溶酶体通路：神经退行性疾病的全新治疗靶点
Li-Pao Fang,Yibo Zhao,Xianshu Bai
Li-Pao Fang
Egor Y Plotnikov,Nadezda V Andrianova
Egor Y Plotnikov
Structure and function of voltage-gated sodium channel Nav1.6: Involvement in the pathological process of neural injury [0.03%]
电压门控钠通道Nav1.6的结构与功能及其在神经损伤病理过程中的作用研究进展
Huaiyuan Wang,Yuhang Wei,Junqi Wang et al.
Huaiyuan Wang et al.
The voltage-gated sodium channel Nav1.6, encoded by the sodium voltage-gated channel alpha subunit 8 gene, is a crucial regulator of neuronal excitability, with widespread expression throughout the central and peripheral nervous systems. Re...
M2 polarization of macrophages: Manipulation of spinal cord injury repair [0.03%]
脊髓损伤修复中的M2型巨噬细胞极化诱导研究进展
Yiran Lu,Hantian Yin,Lingwei Lou et al.
Yiran Lu et al.
Spinal cord injury results in lasting sensory and motor dysfunction with limited regenerative capacity. Macrophages play a crucial role in orchestrating secondary pathogenesis and repair mechanisms through polarization dynamics. Following s...
Sarah Mountadem,Daniel L Voisin,Radhouane Dallel
Sarah Mountadem
N6-methyladenosine modification regulates cell death in cognitive impairment [0.03%]
N6-甲基腺苷修饰通过调节细胞死亡影响认知障碍发病机制
Yiqun Li,Yuxin Zhang,Yanzhen Wang et al.
Yiqun Li et al.
Neurodegenerative diseases are characterized by a decline in brain structure and function. Their pathology involves multiple cell death pathways, including ferroptosis, cuproptosis, and pyroptosis. These pathways are intricately linked to g...
Shh-S100A10 axis curbs neuronal PANoptosis after ischemic stroke [0.03%]
SHH-S100A10轴抑制缺血性脑卒中后的神经元PANoptosis反应
Ling Wang,Hao Tang,Jun Wen et al.
Ling Wang et al.
Acute ischemic stroke is a highly prevalent and disabling disease with poor prognosis. Neuronal death is a major feature after a stroke. PANoptosis is a newly reported pattern of cell death, characterized by pyroptosis, apoptosis, and necro...
Hedgehog signaling activation rescues hypoxia-induced ferroptosis in human brain organoids [0.03%]
刺猬信号激活可修复人脑类器官中缺氧诱导的铁死亡
Simeng Yi,Min Huang,Chunmei Xian et al.
Simeng Yi et al.
Fetal hypoxia disrupts neurodevelopment. In particular, the developing brain is extremely vulnerable to hypoxia injury; however, the specific vulnerable cell types and their underlying molecular mechanisms remain underexplored. In the prese...
Aging epigenome begins to change in age-related neurodegenerative diseases [0.03%]
衰老表观基因组在与年龄相关的神经退行性疾病中开始发生变化
Adam Zaretsky,Debra Toiber
Adam Zaretsky
Spinal cord stimulation: An emerging strategy for chronic pain relief after spinal cord injury [0.03%]
脊髓刺激：脊髓损伤后慢性疼痛缓解的新兴策略
Qiwen Wang,Ying Zhang,Huifeng Zhang et al.
Qiwen Wang et al.
Chronic pain following a spinal cord injury refers to pain that persists or recurs after the injury. This pain can manifest as burning, stinging, or sensations similar to electric shocks. Recent studies have shown that spinal cord stimulati...