WTAP-mediated m6A methylation of SOX2 affects lung adenocarcinoma malignancy via Wnt/β-catenin pathway [0.03%]
WTAP介导的SOX2 m6A甲基化通过Wnt/β-catenin信号通路影响肺腺癌恶性进展
Na Li,Xiangbo Zeng,Hong Xie et al.
Na Li et al.
Background: Lung adenocarcinoma (LUAD) is one of the most common subtypes of lung cancer, characterized by high incidence and mortality rates. SOX2 is a transcription factor associated with the progression of various canc...
Epigenetic silencing of PHYHD1 in hepatocellular carcinoma revealed by integrated multi-omics analysis [0.03%]
多组学分析整合揭示肝细胞癌中PHYHD1表观遗传沉默作用
Tianfu Guo,Yafei Li,Tiansheng He et al.
Tianfu Guo et al.
Introduction: Hepatocellular carcinoma (HCC) is characterized by extensive epigenetic alterations, particularly DNA methylation. Through integrated multi-omics analysis, we identified methylation-driven genes in HCC, incl...
A role for EHMT2 in a novel autosomal recessive neurodevelopmental syndrome? A case report [0.03%]
EHMT2的新自动显性神经发育综合症的作用案例报告
Dmitrijs Rots,Beatriz Cristina de Oliveira,Laura Machado Lara Carvalho et al.
Dmitrijs Rots et al.
Background: EHMT1 and EHMT2 encode histone methyltransferases that form an epigenetic complex mediating mono- and dimethylation of histone H3 at lysine 9 (H3K9me1/2). This complex modulates fundamental biological processe...
GAHIB: graph attention VAE with a hyperbolic information bottleneck for biologically structured single-cell representations [0.03%]
GAHIB：用于生物结构单细胞表示的图注意力VAE与双曲信息瓶颈技术
Zeyu Fu,Jiawei Fu,Xiaoxia Wang et al.
Zeyu Fu et al.
Current single-cell RNA-sequencing (scRNA-seq) variational autoencoders (VAEs) usually emphasise local cell graph structure, hyperbolic latent geometry, or bottleneck compression separately, yet these biases are rarely evaluated together in...
The value of third-generation sequencing for neonatal screening of thalassemia in the Yulin region of Southern China [0.03%]
第三代测序技术在中国南方玉林地区新生儿地中海贫血筛查中的应用价值研究
Sisi Ning,Shibin He,Guanghong Wei et al.
Sisi Ning et al.
Background: Thalassemia is one of the most prevalent and severe monogenic disorders worldwide. In China, a three-tiered prevention and control strategy has been established for this disease, comprising preconception carri...
The miR-16-1-3p passenger strand exhibits functional activity and suppresses malignant phenotypes in osteosarcoma [0.03%]
miR-16-1-3p正义链在骨肉瘤中具有抑癌功能
Wenyu Xue,Yuzhe Wang,Polina Pugacheva et al.
Wenyu Xue et al.
Background: Chemotherapy resistance and disease progression remain major causes of mortality in osteosarcoma (OS). The miR-16 family is linked to tumors, but the specific function and treatment potential of the miR-16-1-3...
A comparative study of SNPscan/CNVplex assay and routine PCR in genetic analysis of thalassemia [0.03%]
SNPscan/CNVplex基因分型和常规PCR方法地中海贫血遗传学分析比较研究
Xiufen Bu,Yang Sun,Siyi Ding et al.
Xiufen Bu et al.
Background: Accurate molecular diagnosis is essential for thalassemia prevention and carrier screening, particularly in high-prevalence regions. Conventional PCR-based methods are widely used in clinical practice but have...
Correction: Editorial: Unraveling GI cancer heterogeneity through single-cell multi-omics approaches [0.03%]
更正：社论：通过单细胞多组学方法解析胃癌异质性
Rick J Jansen,Roberta Bardini,Elena Grassi
Rick J Jansen
[This corrects the article DOI: 10.3389/fgene.2026.1869790.]. Keywords: GI cancers; RNA; multi-omics; single...
Published Erratum
Frontiers in genetics. 2026 Jun 25:17:1907386. DOI:10.3389/fgene.2026.1907386 2026
An integrated phenotypic and molecular approach to identify salinity-tolerant lentil (Lens culinaris Medik) genotypes [0.03%]
整合表型和分子方法鉴定抗盐突变体豌豆品系
Ashutosh Kumar Yadav,Narayana Bhat Devate,Surendra Barpete et al.
Ashutosh Kumar Yadav et al.
Salinity in soil and irrigation water has emerged as a serious challenge to global agricultural productivity. Lentil (Lens culinaris Medik.) is highly sensitive to salinity, particularly during early seedling establishment, which adversely ...
Feasibility of IG and TCR rearrangements quantification in ctDNA for monitoring clinical response in pediatric lymphomas [0.03%]
通过量化ctDNA中的免疫球蛋白和TCR重排监测儿童淋巴瘤临床反应的可行性研究
Milena R Marusco,Rudolph R Vera,Caroline de O Lopes et al.
Milena R Marusco et al.
Introduction: Lymphomas are malignancies of the lymphatic system characterized by clonal rearrangements of immunoglobulin (Ig) and T-cell receptor (TCR) genes. While diagnosis relies on tissue biopsy, circulating tumor DN...