Advances in genetics and multi-omics for ischemic stroke: from pathogenesis to clinical translation [0.03%]
遗传学和多组学在缺血性卒中研究中的进展：从发病机制到临床转化
Siyi Zhao,Lei Liu,Junxiong Wu et al.
Siyi Zhao et al.
Ischemic stroke is a multifactorial, heterogeneous cerebrovascular disease characterized by high incidence, mortality, disability, and recurrence rates. Currently, computed tomography or magnetic resonance imaging represents the gold standa...
S2DA-GO: enhancing protein function prediction via gradient-decoupled cross-attention and semantic priors [0.03%]
S2DA-GO：通过梯度解耦交叉注意力和语义先验增强蛋白质功能预测
Hailong Wang,Fujun Xiang,Jin Zhang et al.
Hailong Wang et al.
Accurate automated protein function prediction is essential for bridging the widening gap between the exponential accumulation of uncharacterized protein sequences and the limited repository of experimentally verified functional annotations...
Mitochondrial DNA reveals high maternal diversity within a weak breed structure in native Kazakhstani horses [0.03%]
线粒体DNA揭示了哈萨克斯坦本地马中较高母系多样性下的弱 breeds 结构
Daniya Ualiyeva,Kairat Dossybayev,Tilek Kapassuly et al.
Daniya Ualiyeva et al.
Understanding the genetic diversity and evolutionary history of domestic horses (Equus caballus) is essential for reconstructing their population dynamics and origins. In this study, we analyzed mitochondrial DNA variation (COI and cytb) in...
Evin İşcan,Aaron B Koenig,Xiaogang Wu
Evin İşcan
Biallelic RSPH4A loss-of-function variants cause primary ciliary dyskinesia in a Chinese patient [0.03%]
RSPH4A双等位基因功能丧失变异导致一名中国患者原发性纤毛运动障碍
Yu-Ting Lu,Hui-Yan Tang,Kai Chen et al.
Yu-Ting Lu et al.
Background: Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterized by defective motile cilia function, affecting approximately one in 7,500 to one in 10,000 live births. Pathogenic variants ...
Genetic profiling of healthy family members of breast and ovarian cancer patients in Estonia [0.03%]
爱沙尼亚乳腺癌和卵巢癌患者家系健康成员的基因分型研究
Mikk Tooming,Kadri Rekker,Kadri Toome et al.
Mikk Tooming et al.
Background: Genetic testing for likely pathogenic/pathogenic variants (PV) in BRCA1, BRCA2, and other cancer-associated genes plays a critical role in the diagnosis, prognosis, and management of breast and ovarian cancer ...
Complementary structure of statistical significance and predictive relevance in explainable machine learning-based transcriptomic tissue classification of Hanwoo cattle [0.03%]
基于可解释机器学习的韩牛组织转录组分类中统计显著性和预测相关性的互补结构
Dogyeong Lee,Junyoung Lee,Inchul Choi et al.
Dogyeong Lee et al.
Understanding tissue-specific transcriptomic structures in livestock is essential for elucidating the molecular basis of economically important traits. Conventional differential gene expression analysis efficiently identifies genes with lar...
Effects of prenatal transportation stress on liver gene expression in male and female Brahman calves [0.03%]
妊娠运输应激对雌雄布拉汉牛犊肝脏基因表达的影响
Sierra R Sebesta,Emilie C Baker,Kubra Z Cilkiz et al.
Sierra R Sebesta et al.
The liver is a central regulator of metabolic and endocrine functions that support fetal growth and postnatal development. Prenatal stress can reprogram hepatic development in the offspring, potentially causing long-term changes in metaboli...
Genomic innovations in cancer prevention, diagnosis, prognosis and precision therapeutics [0.03%]
基因组创新在癌症的预防、诊断、预后和精确治疗中的作用
Hanumappa Ananda,Sadhu R Sahana,Shruthi R Murthy et al.
Hanumappa Ananda et al.
Cancer research has undergone a transformative change with the advent of high-throughput genomic technologies. Advances in next-generation sequencing accelerated the identification of somatic and germline alterations that drive tumorigenesi...
Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics [0.03%]
基于转录组测序和生物信息学的软骨退行性变相关潜在分子标志物及治疗靶点的识别与功能研究
Xiao-Hua Chen,Jun Liu,Ling Qiu et al.
Xiao-Hua Chen et al.
Background and objectives: Osteoarthritis (OA) is a chronic degenerative joint disease. Approximately 300 million people worldwide suffer from OA, which shows a high incidence in middle-aged and elderly populations, with ...