Remodelin treatment reshapes inflammation-related transcriptomic signatures in experimental thalamic hemorrhage [0.03%]
雷米丁治疗重塑实验性丘脑出血炎症相关转录谱型
Zi Wang,Yaqun Li,Yinggang Xiao et al.
Zi Wang et al.
Background: Thalamic hemorrhage is a severe subtype of intracerebral hemorrhage in which secondary neuroinflammation contributes to tissue injury and neurological deterioration. N-acetyltransferase 10 (NAT10), an RNA N4-a...
Escape and evasion: when immunosurveillance of senescent cells goes wrong [0.03%]
逃逸与逃避：免疫监视衰老细胞出错时发生什么
Elina Shakur,Abraham Jacobs,Rituparna Ghosh et al.
Elina Shakur et al.
Aging involves molecular changes that can give rise to different cell fates, one of those being cellular senescence. Senescent cells stably arrest in the cell cycle and play important roles in physiological processes and can act in a tumor-...
Genome-wide association study of the reproductive, body size, and carcass-related latent and directly measured traits in admixed beef heifers [0.03%]
混血肉用母牛繁殖力、体型和胴体性状的全基因组关联分析
Muhammad Anas,Bin Zhao,Haipeng Yu et al.
Muhammad Anas et al.
Latent variables derived through factor analysis reveal the underlying biological traits (UBT) in organisms. However, research on UBT development and genomic applications in beef cattle is limited. This study aimed to model previously ident...
Modifiable risk factors and skin cancers: a multi-omics Mendelian randomization study from causal inference to drug target discovery [0.03%]
从因果推断到药物靶点发现的表观遗传学、基因组学和皮肤癌研究
Zhen Qin,Wuda Huoshen,Xueqing Li et al.
Zhen Qin et al.
Introduction: Recent studies have linked modifiable risk factors (RFs) to melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). This study aimed to investigate the causal relationships between 11 modifi...
Editorial: Deciphering molecular mechanisms behind tumor heterogeneity features by using nucleic acid-based technologies [0.03%]
述评：利用核酸技术解析肿瘤异质性分子机制
Alexis Germán Murillo Carrasco,José Luis Buleje Sono,Manuel Gentiluomo et al.
Alexis Germán Murillo Carrasco et al.
Epigenetic regulation in osteoarthritis: recent updates and emerging mechanisms [0.03%]
骨关节炎的表观遗传调控：最新研究进展与新兴机制
Yujin Zhao,Xianwen Liu
Yujin Zhao
Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by progressive cartilage destruction, synovial inflammation, subchondral bone remodeling, and functional decline. Current treatments remain largely symptomatic...
NIMA-related kinase family at the nexus of skeletal development and congenital arthrogryposis: coordinated regulation of cell cycle and ciliary dynamics [0.03%]
骨骼发育与先天性关节挛缩症的交叉点：NIMA相关激酶家族协调调控细胞周期和纤毛动态
Yitong Zhao,Ying Zheng,Qian Chen et al.
Yitong Zhao et al.
Background: The NIMA-related kinase (NEK) family comprises a group of serine/threonine kinases that play pivotal roles in cell cycle control. Emerging evidence has demonstrated that loss-of-function (LOF) mutations in NEK...
mwHIT: accelerated and accurate histone modification imputation using multi-scale window attention [0.03%]
MW HIT：使用多尺度窗口注意进行加速且准确的组蛋白修饰填充技术
Zhaoxi Zhang,Lijuan Jia,Xiaoya Fan et al.
Zhaoxi Zhang et al.
Histone modifications regulate chromatin organization and gene activity, and abnormal modification patterns are closely associated with disease-related transcriptional dysregulation. Although ChIP-seq provides accurate measurements of histo...
Machine learning prioritization identifies PANX1 as an inflammation-associated candidate regulator in lung adenocarcinoma [0.03%]
机器学习的优先级分析确定PANX1为肺腺癌相关炎症关联候选调节因子
Ya Yang,Tingyuan Fan,Xiaye Miao et al.
Ya Yang et al.
Background: Tumor-associated inflammation is an important contributor to cancer progression and therapeutic resistance. However, the molecular regulators linking inflammatory signaling with tumor biology in lung adenocarc...
Community awareness of genetic disorders associated with consanguineous marriage and acceptance of preventive screening, a cross-sectional study from Saudi Arabia [0.03%]
沙特阿拉伯同族结婚相关遗传病的社区意识及预防筛查的认可度：一项横断面研究
Abdulmajeed A A Sindi,Uthman Albakri,Sarah A Alzahrani et al.
Abdulmajeed A A Sindi et al.
Background: This study assessed community awareness, knowledge, and attitudes toward genetic disorders associated with consanguineous marriage and evaluated acceptance of premarital/genetic screening among adults in Al-Ba...