Structure-adaptive canonical correlation analysis for microbiome multi-omics data [0.03%]
适应结构的典范相关分析在微生物组多组学数据中的应用
Linsui Deng,Yanlin Tang,Xianyang Zhang et al.
Linsui Deng et al.
Sparse canonical correlation analysis (sCCA) has been a useful approach for integrating different high-dimensional datasets by finding a subset of correlated features that explain the most correlation in the data. In the context of microbio...
Haydeé Contreras-Peruyero,Imanol Nuñez,Mirna Vazquez-Rosas-Landa et al.
Haydeé Contreras-Peruyero et al.
The Critical Assessment of Massive Data Analysis (CAMDA) addresses the complexities of harnessing Big Data in life sciences by hosting annual competitions that inspire research groups to develop innovative solutions. In 2023, the Forensic C...
Transcriptome analysis revealed that ischemic post-conditioning suppressed the expression of inflammatory genes in lung ischemia-reperfusion injury [0.03%]
转录组分析显示缺血后处理通过抑制炎症基因表达减轻肺移植再灌注损伤
Liangen Lin,Congcong Sun,Yuanwen Ye et al.
Liangen Lin et al.
Introduction: Ischemic post-conditioning (I-post C) is a recognized therapeutic strategy for lung ischemia/reperfusion injury (LIRI). However, the specific mechanisms underlying the lung protection conferred by I-post C r...
Holliday junction recognition protein (HJURP) could reflect the clinical outcomes of lung adenocarcinoma patients, and impact the choice of precision therapy [0.03%]
节间识别蛋白(HJURP)能反映肺腺癌患者的临床结局并影响精准治疗的选择
Xixi Gao,Yingqing Zhang,Ming Zhang et al.
Xixi Gao et al.
Background: Lung adenocarcinoma (LUAD) is the most prevalent subtype of non-small cell lung cancer (NSCLC), characterized by poor prognosis and a high mortality rate. Identifying reliable prognostic biomarkers and potenti...
GCRTcall: a transformer based basecaller for nanopore RNA sequencing enhanced by gated convolution and relative position embedding via joint loss training [0.03%]
基于变压器的纳米孔RNA测序解码器GCRTcall及其门控卷积和相对位置嵌入联合损失训练方法
Qingwen Li,Chen Sun,Daqian Wang et al.
Qingwen Li et al.
Nanopore sequencing, renowned for its ability to sequence DNA and RNA directly with read lengths extending to several hundred kilobases or even megabases, holds significant promise in fields like transcriptomics and other omics studies. Des...
Case Report: Atypical motor development in a patient with the mosaic form of Down syndrome and spinal muscular atrophy type 2- long-term observation [0.03%]
报告：嵌合型唐氏综合症和脊髓性肌萎缩症2型患儿的不典型运动发育长期观察结果
Ewa Gajewska,Jędrzej Fliciński,Magdalena Sobieska et al.
Ewa Gajewska et al.
A boy is presented in whom Down Syndrome mosaicism and spinal muscular atrophy by overlapping clinical symptoms delayed the diagnosis and caused complicated motor development. The boy from the first pregnancy was delivered vaginally, week 3...
asmbPLS: biomarker identification and patient survival prediction with multi-omics data [0.03%]
基于组学数据的生物标志物识别与患者生存预测方法asmpLS
Runzhi Zhang,Susmita Datta
Runzhi Zhang
Introduction: With the advancement of high-throughput studies, an increasing wealth of high-dimensional multi-omics data is being collected from the same patient cohort. However, leveraging this multi-omics data to predic...
Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study [0.03%]
探索细胞因子、其受体与急性呼吸窘迫综合征之间的因果关系：双向孟德尔随机化研究
Jia-Wei Ma,Ji-Chun Tang,Hong-Zhi Fang
Jia-Wei Ma
Background: Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as In...
Mendelian randomization and bioinformatics unveil potential links between gut microbial genera and colorectal cancer [0.03%]
孟德尔随机化和生物信息学揭示肠道微生物属与结直肠癌之间的潜在联系
Long Wu,Huan Wu,Fei Huang et al.
Long Wu et al.
Background: Colorectal cancer (CRC) poses a significant global health burden, with high incidence and mortality rates. Despite advances in diagnostic and therapeutic modalities, early diagnosis remains critical for improv...
Case report: A case of holocarboxylase synthetase deficiency with respiratory tract as the initial symptom [0.03%]
个例报告：呼吸系统症状初发的全羧化酶合成酶缺乏症患儿
Haiying Zou,Li Yang,Renlong Zhang et al.
Haiying Zou et al.
Introduction: Holocarboxylase synthetase deficiency (HLCSD) is a rare autosomal recessive genetic disorder caused by mutations in the holocarboxylase synthetase (HLCS) gene, which affects multiple systems. Common clinical...