Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis [0.03%]
盐皮质激素受体阻断剂可防治系膜细胞源性肾小球硬化症
Nobuaki Takagi,Takakuni Tanizawa,Valentina Kon et al.
Nobuaki Takagi et al.
Background: We previously showed that angiotensin type 1 receptor (AT1) blocker (ARB) attenuates glomerular injury in Nphs1-hCD25 (NEP25) transgenic mice, a model of selective podocyte injury. However, subsequent studies ...
ACE Inhibition in Anti-Thy1 Glomerulonephritis Limits Proteinuria but Does Not Improve Renal Function and Structural Remodeling [0.03%]
血管紧张素转换酶抑制剂对抗Thy1肾小球肾炎的影响：减少蛋白尿但不能改善肾功能和结构重塑
Peter E Westerweel,Jaap A Joles,Krista den Ouden et al.
Peter E Westerweel et al.
Background/aims: ACE inhibitor (ACE-I) treatment effectively inhibits proteinuria and ameliorates the course of various renal diseases. In experimental glomerulonephritis, however, angiotensin II (AngII) infusion has also...
Thrombin stimulates synthesis of macrophage colony-stimulating factor, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor by human proximal tubular epithelial cells in culture [0.03%]
凝血酶通过培养的人近端小管上皮细胞刺激巨噬细胞集落刺激因子，粒细胞-巨噬细胞集落刺激因子和粒细胞集落刺激因子的合成
Yuko Shimaya,Michiko Shimada,Yoshiko Shutto et al.
Yuko Shimaya et al.
Background/aims: Colony-stimulating factors (CSFs) are well-known hematopoietic growth factors. Although recent studies revealed that CSFs are involved in many inflammatory conditions, the local production of CSFs and its...
Effect of inflammation on the relationship of pulse pressure and mortality in haemodialysis [0.03%]
炎症对血液透析患者脉压与死亡率关系的影响
Debasish Banerjee,Allan J Collins,Charles A Herzog
Debasish Banerjee
Background/aim: The effect of hypertension on mortality in haemodialysis patients is controversial and can be confounded by non-traditional risk factors like systemic inflammation. This study examined the effect of systol...
Serum alkaline phosphatase levels and left ventricular diastolic dysfunction in patients with advanced chronic kidney disease [0.03%]
终末期肾脏病患者血清碱性磷酸酶水平与左心室舒张功能不全的关系研究
Olimpia Ortega,Isabel Rodriguez,Julie Hinostroza et al.
Olimpia Ortega et al.
Background: High levels of alkaline phosphatase (ALP) have been associated with increased mortality in patients with advanced chronic kidney disease (CKD). We hypothesize that elevated ALP could be partly explained by sub...
Noble gas (argon and xenon)-saturated cold storage solutions reduce ischemia-reperfusion injury in a rat model of renal transplantation [0.03%]
富氩和氙的冷存溶液可减少肾移植中再灌注损伤
Y Irani,J L Pype,A R Martin et al.
Y Irani et al.
Background: Following kidney transplantation, ischemia-reperfusion injury contributes to adverse outcomes. The purpose of this study was to determine whether a cold-storage solution saturated with noble gas (xenon or argo...
Identifying depression in South asian patients with end-stage renal disease: considerations for practice [0.03%]
终末期肾病南亚患者的抑郁识别：实践中的考虑因素
Shivani Sharma,Kamaldeep Bhui,Joseph Chilcot et al.
Shivani Sharma et al.
Depression is a prevalent burden for patients with end-stage renal disease (ESRD) and one that is under-recognized and consequently under-treated. Although several studies have explored the association between depression symptoms, treatment...
Rituximab treatment for membranous nephropathy: a French clinical and serological retrospective study of 28 patients [0.03%]
利妥昔单抗治疗膜性肾病的临床和血清学回顾性研究(28例报告)
Pierre-Antoine Michel,Karine Dahan,Pierre-Yves Ancel et al.
Pierre-Antoine Michel et al.
The development of well-tolerated and effective therapies that target the pathogenesis of membranous nephropathy (MN) would be useful. Our objective was to evaluate the efficacy of rituximab in MN. We analyzed the outcome of 28 patients tre...
Plasma S100A12 levels and peripheral arterial disease in end-stage renal disease [0.03%]
终末期肾病患者外周动脉疾病与血浆S100A12水平的关系
Yayoi Shiotsu,Yasukiyo Mori,Tsuguru Hatta et al.
Yayoi Shiotsu et al.
Background: S100A12 is an endogenous ligand of the receptor for advanced glycation end products (RAGE). Plasma S100A12 levels are high in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD). P...
Comparison of estimated protein output and urine protein: creatinine ratio in first and second voids with 24-hour urine protein [0.03%]
随机尿蛋白肌酐比值与晨起尿液及24小时尿液测定蛋白排泄量的比较研究
Viknesh Selvarajah,Robert Flynn,Chris Isles
Viknesh Selvarajah
Background: Current UK guidelines for the identification, management and referral of chronic kidney disease advise an early-morning urine sample for the albumin:creatinine ratio or the protein:creatinine ratio (PCR) in or...