Targeting Tumour Heterogeneity through sequential timing of anti-hallmark combination therapies -a hypothesis for implementation [0.03%]
针对肿瘤异质性通过联合抗标志性治疗的序贯定时治疗假设及其实施方法
Kumara Swamy,Guruaj Arakeri,Ramaswamy Veena et al.
Kumara Swamy et al.
Since the introduction of the hallmarks of cancer framework over 25 years ago, treatment approaches have evolved into personalized medicine, offering benefits to select patient populations. However, three major components of heterotypic int...
Spatial multiomics to inform immunocytokine engineering: knowledge base, gaps, and QC solutions [0.03%]
空间多组学指导免疫细胞因子工程：知识库、缺口和质控解决方案
Priyank Patel,Luke Daniel Batty,Marina Bleck et al.
Priyank Patel et al.
Systemic pro-inflammatory cytokine therapies (e.g., IL-2) represented early milestones in immunotherapy, but their use is hampered by low response rates and severe off-target toxicity. In contrast, immunocytokines deliver cytokines directly...
Deoxyguanosine kinase deficiency couples purine metabolism to innate immune activation and lipid accumulation in hepatocytes [0.03%]
脱氧鸟苷酸激酶缺乏症使嘌呤代谢与固有免疫激活和肝细胞脂质积累相偶联
Maija Corey,Mahati Rayadurgam,Mousa Vatanmakanian et al.
Maija Corey et al.
Introduction: Mitochondrial DNA depletion syndromes (MDS) caused by deoxyguanosine kinase (DGUOK) deficiency are classically attributed to impaired mitochondrial DNA (mtDNA) maintenance. However, many patients develop hep...
Beyond scarring: immune-epithelial crosstalk in wound-induced hair follicle neogenesis [0.03%]
超越瘢痕：伤口诱导的毛囊新生过程中免疫细胞与上皮细胞的相互作用
Ying-Ming Ma,Wei Shen,Xiao-Lei Xie et al.
Ying-Ming Ma et al.
Wound-induced hair follicle neogenesis (WIHN) represents a remarkable regenerative phenomenon observed in adult mammalian skin (predominantly studied in mice), in which large full-thickness wounds bypass fibrotic scarring to generate fully ...
Gut microbiota and intestinal permeability in rheumatoid arthritis: pathogenic mechanisms [0.03%]
肠道微生物群和肠通透性在类风湿关节炎中的病理机制
Jan Bilski,Agata I Schramm-Luc,Marian Szczepanik et al.
Jan Bilski et al.
Rheumatoid arthritis is a chronic systemic autoimmune disease in which the earliest breaks in immune tolerance may arise at mucosal surfaces before the clinical onset of synovitis. Among these sites, the gut has emerged as a particularly co...
Kinase signaling in the control of regulatory T cell function: molecular mechanisms and therapeutic implications [0.03%]
激酶信号在控制调节性T细胞功能中的作用：分子机制和治疗意义
Beibei Tang,Keke Li,Wanyu Chen et al.
Beibei Tang et al.
Regulatory T cells (Tregs) are central to immune regulation, preventing excessive immune responses, maintaining immune tolerance, and modulating inflammatory microenvironments. Dysregulation of Treg development, differentiation, proliferati...
M13 phage-based antigen presentation and immune response activation in vaccine development for animal infectious diseases [0.03%]
基于M13噬菌体的抗原呈递及免疫应答激活在动物传染病疫苗开发中的应用研究
Guodong Zhou,Jiahui Zhang,Zhihui Zhang et al.
Guodong Zhou et al.
Phage display technology has emerged as a versatile platform for vaccine development by integrating antigen presentation with intrinsic immunostimulatory properties. Among the available phage systems, the filamentous bacteriophage M13 has a...
Spatially organized macrophage-T-cell crosstalk in cervical cancer: insights from single-cell and spatial omics [0.03%]
宫颈癌中巨噬细胞-T细胞的时空相互作用：单细胞和空间组学的见解
Li Huang,Nan Lin,Hao Li et al.
Li Huang et al.
Immunotherapy has transformed the therapeutic landscape of advanced cervical cancer, yet clinical benefit remains limited by a highly heterogeneous and immunosuppressive tumor microenvironment. Traditional paradigms, including binary M1/M2 ...
Galectins at the crossroads of tumor immunity, metabolism, and metastasis: mechanisms, therapeutic resistance, and translational opportunities [0.03%]
肿瘤免疫、代谢和转移交叉点的半乳糖凝集素：机制、治疗耐药性和转化机会
Chengxun Jin,Wenjia Wang,Yihang Gao
Chengxun Jin
Galectins, a structurally conserved family of β-galactoside-binding lectins, have emerged as key regulators of cancer progression. However, their integrated roles across tumor immunity, metabolic rewiring, and metastasis have yet to be ful...
Progressive γδ T cell remodelling is associated with type-2 inflammation in eosinophilic chronic rhinosinusitis with nasal polyps [0.03%]
进行性γδT细胞重排与鼻息肉型嗜酸细胞性慢性鼻窦炎的2型炎症相关
Stjepan Grga Milanković,Mario Štefanić,Hrvoje Mihalj et al.
Stjepan Grga Milanković et al.
Introduction: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is a type-2 inflammatory endotype characterised by tissue eosinophilia and mucosal remodelling. γδ T cells are tissue-resident lymphocytes in...