Prediction and immune landscape study of potentially key autophagy-related biomarkers in preeclampsia with gestational diabetes mellitus [0.03%]
Qin Wang,Xiaoqi Li,Wen Ye et al.
Qin Wang et al.
Introduction: Gestational diabetes mellitus (GDM) and preeclampsia are prevalent pregnancy complications that threaten maternal and infant health while imposing substantial socioeconomic burdens. Although several interven...
The POSH scaffold protein is essential for signal coordination leading to CD8 T cell differentiation and survival [0.03%]
Caitlyn Guldenpfennig,Yue Guan,Bela Cseri et al.
Caitlyn Guldenpfennig et al.
Introduction: Upon antigen recognition, naive CD8 T cells must induce c-JUN N-terminal kinase (JNK), NF-κB, and Akt signaling to drive differentiation and generate a heterogeneous effector response. While the roles of th...
The level of I-FABP and IgA/IgG to beta-lactoglobulin in mothers at risk for gestational diabetes and in their children: association with antibodies to Bifidobacterium adolescentis and Bifidobacterium breve [0.03%]
Tamara Vorobjova,Aili Tagoma,Celeste Peterson et al.
Tamara Vorobjova et al.
Background: The mechanisms underlying gestational diabetes mellitus (GDM) and their impact on maternal and child immunity remain unclear. We hypothesize that gut microbiome alterations and increased small intestinal perme...
What do we know about extracellular vesicles in patients with idiopathic pulmonary fibrosis? a scoping review [0.03%]
Maria Conti,Alvise Casara,Graziella Turato et al.
Maria Conti et al.
Extracellular Vesicles (EVs), released by all cell types and detectable in biological samples, carry a variety of biological molecules. These molecules mediate communication and signaling with both local and distant cells, potentially playi...
The performance of sCD25 and CTLs degranulation test for screening patients with primary hemophagocytic lymphohistiocytosis: a large-scale multicenter study in China [0.03%]
Wenshuai Zheng,Zhaoguang Chen,Yibo Cai et al.
Wenshuai Zheng et al.
Background: Hemophagocytic lymphohistiocytosis can be classified as primary HLH (pHLH) and secondary HLH. The early identify of pHLH can facilitate successful treatment. The rapid screening test greatly facilitated the di...
Multicenter Study
Frontiers in immunology. 2025 Jul 2:16:1616541. DOI:10.3389/fimmu.2025.1616541 2025
Wan-Ying Zhang,Lang-Yu Yang,Xing-Xing Fan
Wan-Ying Zhang
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment landscape for hematologic malignancies; however, its efficacy in solid tumors remains limited due to antigen heterogeneity, a suppressive tumor microenvironme...
Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood [0.03%]
Allan Lugaajju,Richard Idro,Stephen Kiwuwa et al.
Allan Lugaajju et al.
Antibodies are important for protection against malaria. For optimal protective activity, it is thought that antibodies need to have high affinity. A longitudinal study conducted in Uganda followed newborn infants and their mothers for nine...
Hilary Montano,Irving Coy Allen,Christopher M Reilly
Hilary Montano
Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which autoantibody production and cytokine dysregulation leads to systemic organ and tissue damage that can result in mortality. Although various environmental, hormonal, and ge...
Xiang-Mei Wen,Zi-Jun Xu,Hao-Xi Ni et al.
Xiang-Mei Wen et al.
Depending on the cellular context and cancer type, FOXP1 functions as an oncogene or a tumor suppressor. However, the clinical role of FOXP1 in hematologic malignancies has not been studied comprehensively. This study systematically analyze...
B-cell epitope prediction for developing allergy vaccines and their companion immunodiagnostics [0.03%]
Robbi Miguel G Falcon,Serina U Fahrenbach,Louise Claire E Ortiz et al.
Robbi Miguel G Falcon et al.