Ming-Zhen Dong,Ming Cui,En-Bo Zhu et al.
Ming-Zhen Dong et al.
Cadonilimab is the first bispecific antibody independently developed in China that simultaneously targets Programmed Cell Death Protein-1 (PD-1) and Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4), marking a significant milestone in bo...
Multimodal analysis of TAAD pathogenesis: SHAP-enhanced interpretable models and single-cell sequencing analysis reveal immune microenvironment alterations [0.03%]
多模态分析TAAD发病机制：SHAP增强的可解释模型和单细胞测序分析揭示免疫微环境改变
Zhong Wang,Yixian Wang,Dianjun Tang et al.
Zhong Wang et al.
Background: Stanford type A aortic dissection (TAAD) is a fatal cardiovascular emergency with high mortality within 48 hours. Elucidating molecular mechanisms and identifying reliable biomarkers are essential for improvin...
Integrative causal inference and predictive modeling reveal the iron-related gene SLC17A4 as a key biomarker in chronic rhinosinusitis [0.03%]
整合因果推理和预测模型揭示慢性鼻窦炎中铁相关基因SLC17A4作为关键生物标志物的重要性
Jiajia Lv,Feifei Jiang
Jiajia Lv
Purpose: To investigate whether iron metabolism exerts a causal influence on chronic rhinosinusitis (CRS) and to identify iron-related biomarkers and regulatory genes with diagnostic and therapeutic potential. ...
Experience in emergency management of first-episode immune thrombotic thrombocytopenic purpura over the past 21 years: a single-center retrospective study [0.03%]
既往21年以急性免疫性血栓性血小板减少性紫癜病例为主的单中心回顾性研究经验总结
Liqian Zhang,Wenfeng Huang,Fengtao Yang et al.
Liqian Zhang et al.
Background: Immune thrombotic thrombocytopenic purpura (iTTP) is a rare but fatal hematologic disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and multiorgan dysfunction. Early diagnosis and ...
Integrating cuproptosis- and ferroptosis-related gene signatures to predict prognosis, immunotherapy response, and drug sensitivity in patients with skin cutaneous melanoma [0.03%]
整合杯状细胞凋亡和铁死亡相关基因特征以预测皮肤黑色素瘤患者的预后、免疫治疗反应和药物敏感性
Hua Dong,Ying Huang,Jie Shen et al.
Hua Dong et al.
Objective: Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy originating from melanocytes, with a continuously rising global incidence. Developing strategies for early prevention and precise treatment remai...
Inflammation mediates the association between the Prognosis Nutrition Index (PNI) and mortality in acute pancreatitis: evidence from international cohorts [0.03%]
炎症介导了急性胰腺炎患者预后营养指数(PNI)与死亡率之间的关系：国际队列研究证据
Lingwei Huang,Dan Xiao,Lingjie Yan et al.
Lingwei Huang et al.
Background: The prognostic nutritional index (PNI), reflecting nutritional and immune-inflammatory status, has been linked to outcomes across a range of disorders. Its prognostic value in acute pancreatitis (AP) and the p...
Case Report: Ramsay Hunt syndrome with simultaneous bilateral vestibular dysfunction as the initial manifestation in a patient with a history of breast cancer [0.03%]
个案报告：一位乳腺癌病史患者以双侧前庭功能障碍为首发表现的亨特氏综合征
Shusheng Jiao,Miaomiao Li,Xiaofang Cheng et al.
Shusheng Jiao et al.
Background: Ramsay Hunt syndrome (RHS) typically presents with unilateral otalgia, herpes zoster oticus, ipsilateral peripheral facial palsy, and often ipsilateral vestibulocochlear involvement. Bilateral/contralateral ve...
Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production [0.03%]
巨噬细胞TRIM21乳酸化通过增强STAT1介导的CXCL9和CXCL10产生而加重感染相关性睾丸炎
Wenjing Tang,Wenjie Chen,Na Li et al.
Wenjing Tang et al.
Introduction: Infection-induced orchitis, a leading cause of acquired male infertility affecting 8%-12% of couples globally, is driven by unresolved inflammatory responses following bacterial infection. ...
Dysregulation of the microbiota-gut-brain axis induced by chronic pancreatitis mediates anxiety- and depression-like behaviors in mice [0.03%]
慢性胰腺炎通过破坏肠-菌群-脑轴的调节诱导小鼠产生类似焦虑和抑郁的行为
Leheng Liu,Xi Zhang,Chuanyang Wang et al.
Leheng Liu et al.
Background: Anxiety and depression are common psychological complications in patients with chronic pancreatitis (CP). This study aims to investigate the dysregulation of microbiota-gut-brain axis induced by CP in driving ...
Disproportionality analysis of satralizumab in FDA adverse event reporting system and Japanese adverse drug event report: a pharmacovigilance study [0.03%]
Satralizumab不良反应报告的 disproportionality 分析：来自美国食品药品管理局不良事件报告系统和日本药物警戒数据库的一项药物流行病学研究
Linhai Zhang,Rong Yan,Zucai Xu
Linhai Zhang
Background: To date, no post-marketing safety studies of satralizumab have been conducted. This study aims to evaluate the post-marketing safety profile of satralizumab using data from the U.S. Food and Drug Administratio...