Lucia Buccarello,Anna Privitera,Konstantinos Partsinevelos et al.
Lucia Buccarello et al.
Microglia are a key driver of neurodegenerative disease, orchestrating inflammatory signaling, metabolic stress responses, synaptic remodeling, and neuronal fate within the central nervous system (CNS). Among experimental models, the human ...
Impact of TP53 mutations on survival outcomes in the CAR-T era of large B-cell lymphoma [0.03%]
CAR-T时代TP53突变对大B细胞淋巴瘤生存结局的影响
Rui Liu,Zhonghua Fu,Fan Yang et al.
Rui Liu et al.
Purpose: TP53 mutations are among the strongest adverse prognostic factors in large B-cell lymphoma (LBCL) treated with chemoimmunotherapy. Whether this unfavorable prognostic impact persists in the era of chimeric antige...
Beyond hepatitis C: clinical spectrum and demographic characteristics of anti-rods and rings antibodies in a large ANA-positive cohort [0.03%]
乙型肝炎之外：大型抗核抗体阳性队列中抗杆环状体抗体的临床分型及人群特征
Pingping Wang,Shiji Wu,Jingting Liu et al.
Pingping Wang et al.
Background: The anti-rods and rings (anti-RR) pattern (AC-23) is traditionally associated with Hepatitis C Virus (HCV) infection and interferon therapy. However, emerging evidence suggests a broader clinical spectrum. Thi...
From immunological mechanisms to targeted therapies: a bibliometric analysis in the domain of research concerning neutrophil extracellular traps and pulmonary diseases (2006-2025) [0.03%]
从免疫机制到靶向治疗：关于中性粒细胞胞外陷阱和肺部疾病研究领域的文献计量分析（2006-2025）
Yingqi Pan,Gang Liu,Hui Wang et al.
Yingqi Pan et al.
Objectives: Neutrophil extracellular traps (NETs) are a crucial mechanism of the neutrophil immune response and exhibit complex dual pathological and physiological effects in pulmonary diseases. In recent years, this rese...
T-cell engagers in cancer immunotherapy: mechanisms, challenges, and future perspectives [0.03%]
癌症免疫治疗中的T细胞衔接剂：机制、挑战及未来前景
Kaaviyaa Muthughavi,Manoj Khokhar,Hem Chandra Jha et al.
Kaaviyaa Muthughavi et al.
T-cell engagers (TCEs) are a rapidly evolving class of cancer immunotherapies that redirect cytotoxic T cells to tumor-associated antigens independently of MHC presentation. This review outlines the development, structural formats, and ther...
A pharmacovigilance study of sirolimus-associated adverse events in organ transplantation [0.03%]
他克莫司致器官移植受者不良事件的药物流行病学研究
Da-Zhuang Yi,Yan Jiao,Cai-Feng Xiu et al.
Da-Zhuang Yi et al.
Background: Sirolimus (rapamycin), an antibiotic discovered in the 1970s, can effectively reduce allograft rejection, and plays an important role in the fields of immunosuppressive therapy and organ transplantation. There...
Docetaxel enhances Vβ-directed T-cell activation and antitumor immunity mediated by a bifunctional TCR agonist in breast and prostate cancer models [0.03%]
多西他赛增强Vβ定向T细胞活化和双功能TCR激动剂介导的乳腺癌和前列腺癌模型中的抗肿瘤免疫作用
Jonelle K Lee,Kellsye P Fabian,Ginette S Santiago-Sanchez et al.
Jonelle K Lee et al.
Background: STAR0602 is a selective bifunctional T cell agonist targeting Vβ6/Vβ10 T-cell receptors fused to interleukin-2, with emerging clinical activity in anti-PDL1-resistant tumors. Its murine surrogate, mSTAR1302,...
Immunotherapy-based adjuvant treatment after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma according to pathological response [0.03%]
新辅助免疫化疗后根据病理反应进行基于免疫治疗的食管鳞癌辅助治疗
Chenyu Wang,Xiaoran Geng,Xinyu Cheng et al.
Chenyu Wang et al.
Background: Neoadjuvant immunochemotherapy (NICT) is increasingly used in patients with locally advanced resectable esophageal squamous cell carcinoma (ESCC). However, optimal postoperative adjuvant treatment strategies r...
A C57BL/6N mice model of CP/CPPS established by prostate antigen immunization with DPT and BCG co-administration [0.03%]
DPT和BCG联合应用的前列腺抗原免疫建立C57BL/6N小鼠慢性盆腔疼痛综合征模型
Yu Guan,Andong Cheng,Yiding Chen et al.
Yu Guan et al.
Background and objective: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is common in young and middle-aged men, but existing animal models have key limitations. We aimed to establish a C57BL/6N mice model for...
A proteome-wide atlas of humoral immunity to Mycobacterium tuberculosis across the spectrum of disease [0.03%]
结核分枝杆菌疾病谱中体液免疫的蛋白质组组图谱
Mehak Z Khan,Edward B Irvine,Deniz Cizmeci et al.
Mehak Z Khan et al.
Exposure to Mycobacterium tuberculosis (Mtb) leads to a spectrum of outcomes, from latent infection to active disease, but limited insight into protective immune correlates has hampered vaccine development. Using a proteome-wide Mtb microar...