STING-targeting PROTACs: emerging therapeutic tools for enhanced immunotherapy in inflammatory diseases [0.03%]
靶向STING的PROTACs：增强炎症性疾病免疫治疗的新工具
Wenqing Jiang,Xiaoping Yang,Huiying Liu et al.
Wenqing Jiang et al.
The stimulator of interferon genes (STING) pathway is a central regulator of innate immunity, mediating host defense against pathogens but driving chronic inflammation when dysregulated-underpinning autoimmune diseases, fibrosis, and cancer...
Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus [0.03%]
单细胞核转录组揭示人类海马体脓毒症相关神经血管功能障碍
Liu Liu,Pengfei Li,Brent A Wilkerson et al.
Liu Liu et al.
Introduction: Sepsis is increasingly recognized as a major precipitant of long-term cognitive impairment, yet the cellular mechanisms underlying hippocampal vulnerability remain elusive. ...
Modified recombinant collagen-peptide/gallic acid grafted chitosan composites with antibacterial and antioxidant property for wound dressing: a preliminary study [0.03%]
一种新型重组胶原肽/没食子酸壳聚糖接枝敷料材料的制备及其体外性能研究
Yu Chen,Wenjie Wen,Jie Wang et al.
Yu Chen et al.
Chronic wounds pose a persistent clinical challenge, primarily due to prolonged bacterial infections. The development of natural antibacterial dressings offers a promising strategy for their effective management. In this study, recombinant ...
Cytotoxic CD4+ T-follicular cells may mediate killing against lymphoma cells [0.03%]
细胞毒性CD4+滤泡T细胞可能介导对淋巴瘤细胞的杀伤作用
Yin Xiao,Sigrun S Haeusl,Gaurav Jethva et al.
Yin Xiao et al.
Recently, we have identified CD4+PD-1+CXCR5+ T-follicular helper (TFH) cells with a distinct cytotoxic phenotype and named them "killer TFH (TF K )" cells. In this study, we aim to elucidate their presence and functional relevance in two di...
Siqing Chen,Zhang Qin,Xiaoyuan Lin et al.
Siqing Chen et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel (IBD) disease characterized by a complex pathogenesis and limited treatment options. Macrophages play a key role in the pathophysiology of UC by regulati...
First report from the Czech national registry of inborn errors of immunity (2012-2025) [0.03%]
捷克先天性免疫缺陷国家登记册首份报告（2012-2025年）
Zita Chovancova,Eva Hlavackova,Roman Hakl et al.
Zita Chovancova et al.
Introduction: Congenital immune system defects represent an ever-growing group of diseases characterized by increased susceptibility to infections and association with autoimmune, autoinflammatory, allergic and malignant ...
TNFSF14 (LIGHT) in intestinal inflammation: balancing immune activation and resolution in IBD [0.03%]
肠炎中的TNFSF14（LIGHT）：在炎症性肠病中平衡免疫活化和消退作用
Rabia S Mousa,Pietro Invernizzi,Joanne L Jones et al.
Rabia S Mousa et al.
Inflammatory Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, is an umbrella term used to describe a group of autoimmune conditions characterized by chronic, relapsing inflammation of the gastrointestinal tract. The...
Case Report: A rare case of complex Behçet's disease complicated with acute tubular necrosis and IgA nephropathy, coexists with myelodysplastic syndrome, trisomy 8 and intestinal involvement [0.03%]
病例报告：罕见的白塞病合并急性肾小管坏死及IgA肾病，并伴有骨髓异常综合症、8号染色体三倍体及肠受累
Peipei Zhang,Wen Zhang,Hong Xia et al.
Peipei Zhang et al.
Behçet's disease (BD) is a rare systemic disease in which small-vessel vasculitis impacts multiple bodily organs. It is typically marked by recurrent oral and genital ulcers, uveitis, and cutaneous lesions. However, peripheral vessels, car...
Yuting Yang,Qiqi Ma,Mei Yang et al.
Yuting Yang et al.
Caveolin-1 (Cav-1) is an important structural protein that constitutes the caveolae on the cell membrane. Cav-1 is expressed in various cells, especially in white adipocytes and endothelial cells. Cav-1 plays an important physiological role...
DKA with negative DM-autoantibodies, complicated by GBS and RESLES: a case report and literature review [0.03%]
伴有GBS和RESLES的DM自身抗体阴性的糖尿病酮症酸中毒病例报告及文献回顾
Nan Tian,Yanwen Yang,Qiang Liu et al.
Nan Tian et al.
Guillain-Barré syndrome (GBS) is an autoimmune-mediated disorder characterized by acute, multifocal peripheral neuropathies, typically triggered by infections, autoimmune diseases, or immunosuppressive therapies. In this report, we describ...