Development and validation of a cytokine-based diagnostic model for Kikuchi-Fujimoto disease [0.03%]
用于诊断Kikuchi-Fujimoto病的细胞因子模型的开发和验证
Xiaona Zhu,Chen Liu,Zhi Yang et al.
Xiaona Zhu et al.
Objective: The diagnosis of Kikuchi-Fujimoto disease (KFD) is challenging, which is mainly based on typical histopathological findings from a lymph node biopsy. We aimed to develop and validate a predictive model for the ...
Case Report: Long-term TCR repertoire dynamics in a disease-free survival stage IIIB-N3 lung adenocarcinoma patient treated with anti-PD-1 followed by surgery [0.03%]
病例报告：抗PD-1治疗后手术的IIIB-N3期肺腺癌无病生存者的长期TCR谱系动态研究
Xiaoqian Zhai,Yongcheng Liu,Manhua Wang et al.
Xiaoqian Zhai et al.
Immune checkpoint blockade (ICB) therapy has dramatically improved the survival outcomes of patients with locally advanced unresectable and metastatic non-small cell lung cancer (NSCLC). In particular, accumulated clinical trials and system...
Multimodal temporal dissociation in anti-GABAA receptor encephalitis: functional recovery precedes structural resolution-a case report [0.03%]
抗GABA受体脑炎的多模态时序分离：功能恢复先于结构改善-病例报告
Yi Huang,Jiayue Li,Qi Gao et al.
Yi Huang et al.
Background: Anti-γ-aminobutyric acid A receptor (GABAA receptor) encephalitis is a rare but severe subtype of autoimmune encephalitis (AE), typically characterized by refractory seizures and rapidly progressive neurologi...
Identification of LILRB4 as a regulator of M2c macrophages and a potential immunotherapeutic target in ovarian cancer [0.03%]
鉴定LILRB4为卵巢癌M2c巨噬细胞调节因子及潜在免疫治疗靶点
Huijuan Zhou,Qing Zhang,Bo Yin et al.
Huijuan Zhou et al.
Introduction: Ovarian cancer (OC) is the most lethal gynecological malignancy. A deeper insight into tumor microenvironment (TME) interactions is essential for developing novel therapeutic approaches. leukocyte immunoglob...
Integrative machine learning and single-cell analysis identifies nicotine-related diagnostic genes and myeloid remodeling in COPD [0.03%]
整合机器学习和单细胞分析识别COPD相关诊断基因及髓样重塑
Wei Zhang,Hongmei Sheng,Yueyue Shi et al.
Wei Zhang et al.
Background: Cigarette smoke is a major risk factor for chronic obstructive pulmonary disease (COPD), but its toxicity results from multiple harmful constituents. Nicotine is a chemically defined and biologically active to...
CD73 is associated with glycolysis related metabolic programs and CD8+ T cell suppression in pancreatic ductal adenocarcinoma [0.03%]
CD73与糖酵解相关的代谢程序相关，并抑制胰腺导管腺癌中的CD8+T细胞
Eriko Katsuta,Aarohan Mukherjee Burma,Eito Nakagawa et al.
Eriko Katsuta et al.
CD73 is an enzyme that generates extracellular adenosine and has been implicated in tumor-associated immune suppression, but its biological and clinical significance in pancreatic ductal adenocarcinoma (PDAC) remains incompletely understood...
Immunosenescence shapes the tumor immune microenvironment and limits PD-1/PD-L1 blockade efficacy in older patients with cancer [0.03%]
免疫衰老塑造了老年肿瘤患者的肿瘤免疫微环境并限制PD-1 / PD-L1阻断的疗效
Xiaoyu Niu,Ziwaregul Nur,Wenkang Xie et al.
Xiaoyu Niu et al.
As the global population ages, immunosenescence is emerging as a critical determinant of cancer outcomes in older adults. Although programmed cell death protein 1/protein programmed death-ligand 1 (PD-1/PD-L1) blockade has significantly imp...
A robust and scalable immunoadsorbent platform based on the high-affinity M03-IgG antibody for targeted IL-6 Removal in cytokine storm [0.03%]
一种基于高亲和力M03-IgG抗体的免疫吸附平台用于细胞因子风暴中的靶向白介素-6清除：该平台具有 robust且可扩展性
Yaxi Yang,Lei Wan,Youjia Qin et al.
Yaxi Yang et al.
The therapeutic removal of interleukin-6 (IL-6) via blood perfusion has demonstrated clinical efficacy in the management of autoimmune diseases and sepsis. However, efficient clearance is hindered by the complexity of blood, which contains ...
Integrated peripheral immune profiling reveals B-cell dysregulation and CD8 effector signatures in chronic inflammatory demyelinating polyneuropathy [0.03%]
整合的外周免疫特征分析揭示了慢性炎症性脱髓鞘多发性神经病中的B细胞调节障碍和CD8效应物特征
Hyunjin Kim,Jinhui Chun,Do Hyeon Cha et al.
Hyunjin Kim et al.
Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated peripheral neuropathy with heterogeneous and often incomplete responses to current immunotherapies, but the underlying immune basi...
Decoding benign prostatic hyperplasia at single-cell resolution: heterogeneity, inflammation, and beyond androgen-driven pathogenesis [0.03%]
单细胞分辨率下解读良性前列腺增生：异质性、炎症及超越雄激素驱动的发病机制
Yihao Liao,Siyuan Jiang,Haohan Wang et al.
Yihao Liao et al.
Benign prostatic hyperplasia (BPH) represents a highly prevalent age-related disorder, traditionally managed through androgen-driven pathways. However, the limited efficacy of conventional hormonal therapies in a substantial subset of patie...