Interaction networks of macrophage glycolysis and inflammation in sepsis: mechanisms and therapeutic potential [0.03%]
Peiyao Luo,Hao Liu,Ting Zhang et al.
Peiyao Luo et al.
Sepsis is a severe threat to human health with high mortality rates, but so far its pathogenesis is unclear and lacks effective therapeutic drugs. Macrophages function as one of the most important innate immune cells and play an integral ro...
Expression profiling of inhibitory immune checkpoints in colorectal cancer stem cells and their association with tumor immunity and immunotherapy biomarkers [0.03%]
Ola J Hussein,Muhammad Ammar Zahid,Hanan H Abunada et al.
Ola J Hussein et al.
Background: Colorectal cancer stem cells (CSCs) represent a rare subpopulation within tumors endowed with self-renewal capabilities and are recognized as key drivers of tumor initiation, metastasis, and therapeutic resist...
Circular RNA therapeutics: a new class of long-acting RNA medicines for oncology, immunology, and rare diseases [0.03%]
Okechukwu Paul-Chima Ugwu,Michael Ben Okon,Fabian Chukwudi Ogenyi et al.
Okechukwu Paul-Chima Ugwu et al.
Circular RNAs (circRNAs) have progressed from being viewed as splicing by-products to emerging therapeutic constructs with a distinct pharmacology. Their covalently closed topology can increase RNA stability, prolong intracellular persisten...
Role of dual specificity phosphatase 1 in influencing inflammatory pathways in macrophages modulated by Borrelia burgdorferi lipoproteins [0.03%]
Venkatesh Kumaresan,Susanta Pahari,Chiung-Yu Hung et al.
Venkatesh Kumaresan et al.
Borrelia burgdorferi (Bb), the spirochetal agent of Lyme disease, has a large array of lipoproteins that play a significant role in mediating host-pathogen interactions within ticks and vertebrates. While prior work has established that bor...
The cardiovascular-immune axis: crosstalk and therapy in atherosclerosis, myocarditis and vasculitis [0.03%]
Yuan-Peng Liao,Yu-Xin Wei,Feng-Mei Zhang et al.
Yuan-Peng Liao et al.
Atherosclerosis (AS), myocarditis and vasculitis constitute a spectrum of prevalent cardiovascular diseases (CVDs) where immune dysregulation acts as a central pathogenic driver. Consequently, targeting the immune-cardiovascular axis repres...
Integrative analysis of transcriptomics, single-cell RNA sequencing, and GraphBAN identifies de novo lipogenesis-associated genes and their potential roles in diabetic retinopathy [0.03%]
Zhenghong Jin,Yichen Dong,Rong Xue et al.
Zhenghong Jin et al.
Background: Diabetic retinopathy (DR) represents a key microvascular disorder resulting from prolonged diabetes mellitus. Hyperglycemia, a common driver of diabetes-related vision loss, can pathologically activate de novo...
Zanubrutinib-based regimen as the salvage or bridging treatment of CART therapy in relapsed or refractory, non-germinal center B-cell-like diffuse large B-cell lymphoma: a retrospective multicenter cohort study [0.03%]
Yan Lu,Shiguang Ye,Lili Zhou et al.
Yan Lu et al.
Background: Relapsed or refractory (R/R) non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL) shows poor clinical outcomes. Bruton tyrosine kinase (BTK) inhibitors have established therapeutic a...
Multicenter Study
Frontiers in immunology. 2026 Apr 7:17:1806191. DOI:10.3389/fimmu.2026.1806191 2026
Elevated IL-17A level is associated with poor overall survival following immune checkpoint inhibitors combined with targeted therapy in hepatocellular carcinoma with hyperbilirubinemia [0.03%]
Jianing Wang,Shida Pan,Chuyue Xiong et al.
Jianing Wang et al.
Background: Combination therapy with programmed death-1 (PD-1) inhibitors and targeted therapy is a first-line treatment for advanced hepatocellular carcinoma (HCC). Patients with hyperbilirubinemia (total bilirubin > upp...
Adapting federated radiomics models for radiation pneumonitis prediction in patients receiving thoracic radiotherapy with immunotherapy [0.03%]
Zirui Zhu,Meng Yan,Wenhao Ji et al.
Zirui Zhu et al.
Background and purpose: Radiation pneumonitis (RP) is one of the major dose-limiting toxicities of thoracic radiotherapy. Although multiple studies have attempted to predict RP, robust multicenter model development is oft...
Multicenter Study
Frontiers in immunology. 2026 Apr 7:17:1793039. DOI:10.3389/fimmu.2026.1793039 2026
Danielle J Sisnett,Katherine B Zutautas,Dan H N Vo et al.
Danielle J Sisnett et al.
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and surviva...