The myeloid switch: immune drivers in atopic dermatitis - roles in pathogenesis and emerging therapeutic targeting [0.03%]
髓系细胞转化：特应性皮炎中的免疫驱动因素——在发病机制及新兴治疗靶点中的作用
Erik Kupschke,Mirjam Schenk
Erik Kupschke
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide, significantly impairing patients' quality of life. It is characterized by recurrent eczematous lesions, intense pruritus, and disruption of the e...
Longitudinal immune profiling following autologous hematopoietic stem cell transplantation in multiple sclerosis: insights into immune reconstitution and disease modulation [0.03%]
自身造血干细胞移植后多发性硬化症的纵向免疫特征分析：对免疫重建和疾病调节的新认识
Malin Müller,Ivan Pavlovic,Anna Wiberg et al.
Malin Müller et al.
Introduction: Autologous hematopoietic stem cell transplantation (AHSCT) is an effective treatment for relapsing remitting multiple sclerosis, yet the mechanisms underlying immune reset and sustained remission remain inco...
Editorial: Mitochondrial damage interacts with the immune system and tumor microenvironment [0.03%]
述评：线粒体损伤与免疫及肿瘤微环境之间的相互作用
Xundong Lin,Xin Yuan,Yiheng Luo et al.
Xundong Lin et al.
Bioinformatics-based analysis of nicotinamide adenine dinucleotide metabolism-related genes to predict immune status and prognosis for head and neck squamous cell carcinoma patients [0.03%]
基于生物信息学的烟酰胺腺嘌呤二核苷酸代谢相关基因分析以预测头颈鳞癌患者的免疫状态及预后
Zhenjie Guan,Xinyu Gu,Lian Zheng
Zhenjie Guan
Background: Patients suffering from head and neck squamous cell carcinoma (HNSCC) have a high recurrence rate and poor prognosis. Nicotinamide adenine dinucleotide (NAD+) is crucial in the progression of the tumor. Curren...
An assembled molecular signaling map of interleukin-24: a resource to decipher its multifunctional immunoregulatory role in pathophysiological conditions [0.03%]
组装的分子信号通路图谱揭示白细胞介素-24在病理条件下的多功能免疫调节作用
Anjana Aravind,Vineetha Shaji,Mukhtar Ahmed et al.
Anjana Aravind et al.
Introduction: Interleukin-24 (IL-24) is a cytokine belonging to the IL-10 family with immunoregulatory properties. It is known to induce cellular responses in various disease conditions, including inflammatory, infectious...
Influenza-specific antibody-mediated and complement-dependent cellular cytotoxicity-inducing antibodies in vaccinated and infected pigs [0.03%]
疫苗接种和感染猪的流感抗体介导的和补体依赖的细胞毒性诱导抗体
Mithilesh Singh,Gabriela Mansano do Nascimento,Sankar Renu et al.
Mithilesh Singh et al.
In addition to neutralizing activity, antibodies can contribute to protection against viral infections through antibody-dependent cellular cytotoxicity (ADCC) and antibody-mediated complement-dependent cell cytotoxicity (CDC) mediated via F...
Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates [0.03%]
基于Der p 2的IgE表位靶向突变体的前期过敏性评估表明其作为低致敏 allergoid免疫疗法候选药物的潜力
Glorismer Pena-Amelunxen,Mohadeseh Asghari,Kriti Khatri et al.
Glorismer Pena-Amelunxen et al.
Background: Advancements in hybridoma technology have enabled the production of human IgE monoclonal antibodies (hIgE mAb) for successful IgE epitope mapping of major allergens. Here, we assessed the hypoallergenicity of ...
Exercise improves pulmonary fibrosis and neurological symptoms via S100A12 inhibition [0.03%]
运动通过抑制S100A12改善肺纤维化和神经症状
Yan Sun,Meng Li,Jingmin Yuan et al.
Yan Sun et al.
Background: Neurological symptoms are commonly observed in patients with idiopathic pulmonary fibrosis (IPF). However, the underlying mechanisms remain unclear. Although exercise has been shown to improve pulmonary fibros...
Lin Liu,Qin Yue,Jinhao Chen et al.
Lin Liu et al.
Sepsis is a syndrome of inflammatory response syndrome (SIRS) triggered when the host is exposed to bacterial, viruses, and other infectious agents. The resulting inflammation compromises intestinal integrity, and this gut injury subsequent...
TGF-β inhibitors: the future for prevention and treatment of liver fibrosis? [0.03%]
转化生长因子β抑制剂：预防和治疗肝纤维化的未来方向？
Weili Wang,Yilin Gao,Yizhen Chen et al.
Weili Wang et al.
Liver fibrosis is a core pathological process in the progression of chronic liver diseases to cirrhosis and hepatocellular carcinoma, characterized by abnormal deposition of extracellular matrix. Transforming growth factor-β (TGF-β), thro...