Xinyin Liu,Yiwen Fang,Yicheng Xu et al.
Xinyin Liu et al.
Background: The progression of chronic kidney disease (CKD) is closely linked to gut microbiota dysbiosis and the consequent accumulation of harmful microbial metabolites, forming a vicious cycle called "gut-kidney axis."...
Development of a GMMA-based candidate vaccine against invasive nontyphoidal Salmonella disease [0.03%]
一种基于GMMA的候选疫苗可预防侵袭性非伤寒沙门氏菌病
Francesco Citiulo,Oliver Koeberling,Omar Rossi et al.
Francesco Citiulo et al.
Introduction: Invasive nontyphoidal Salmonella (iNTS) disease is one of the most common causes of bacteremia in sub-Saharan Africa (sSA), mostly affecting children less than 5 years of age and with an associated 14.7% cas...
SAPHO syndrome with membranous nephropathy and analgesic-induced nephropathy: a case report [0.03%]
有关SAPHO综合征合并膜性肾病和解热镇痛药肾病的病例报告
Yuxin Qiao,Zuo Wang,Guohua Li et al.
Yuxin Qiao et al.
SAPHO syndrome is a rare autoimmune disorder, and the occurrence of renal involvement in this condition is even more uncommon. We report the case of a 43-year-old male patient with SAPHO syndrome, who initially presented with palmoplantar p...
Spatial topology and competitive access differentially shape early T cell priming in the lymph node: an agent-based modeling approach [0.03%]
基于空间拓扑和竞争性访问的淋巴结中T细胞启动的代理建模方法学研究
Laia Vancells,Leopold Green,Nan Kong
Laia Vancells
Introduction: Adaptive immune activation in lymph nodes requires rare antigen-specific naïve T cells to locate antigen-bearing dendritic cells within a spatially structured stromal network. Reduced priming efficiency is ...
Extracellular vesicle signalling in perioperative neurocognitive disorders [0.03%]
围手术期神经认知障碍的细胞外囊泡信号通路研究
Jian Li,Min Yu
Jian Li
Perioperative neurocognitive disorders (PND), including postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder, are important complications in older and vulnerable surgical patients. These conditi...
Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus [0.03%]
系统性红斑狼疮女性患者树突状细胞耐受功能障碍的基因表达谱分析
Ana Laura Hernández-Ledesma,Evelia Lorena Coss-Navarrete,Sofia Salazar-Magaña et al.
Ana Laura Hernández-Ledesma et al.
Background: Dendritic cells (DCs) are central regulators of immune tolerance, and disturbances in their phenotype and function contribute to the breakdown of self-tolerance in systemic lupus erythematosus (SLE). Tolerogen...
Mechanisms and therapeutic advances of gut metabolites in the regulation of neuroimmune inflammatory diseases [0.03%]
肠道代谢产物在神经免疫性疾病治疗中的机制和进展
Xiaodan Shen,Caiji Zheng,Renyong Lin et al.
Xiaodan Shen et al.
Gut-derived metabolites function as critical signaling intermediaries that translate environmental cues into central nervous system (CNS) responses, playing an indispensable role in the pathogenesis and trajectory of neuroimmune inflammator...
Is Kaposi's sarcoma the end of the OX40/OX40L axis in atopic dermatitis? [0.03%]
奥氏腹蛇毒肝素酶的发现及其在调节血液凝固和心血管稳态中的作用
Shahram Salek-Ardakani
Shahram Salek-Ardakani
The OX40/OX40L axis entered clinical development in atopic dermatitis with a strong biological rationale and early signs of durable activity. However, as the treatment landscape evolved, questions emerged about whether the magnitude of mono...
BCL-XL drives fibrotic and leukemic progression in myeloproliferative neoplasms [0.03%]
BCL-XL促进骨髓增生性肿瘤的纤维化和白血病进展
Chunyan Wu,Yiting Wang,Quanchao Zhang et al.
Chunyan Wu et al.
Background: Myeloproliferative neoplasms (MPNs) are frequently accompanied by bone marrow fibrosis and leukemic transformation, yet the cellular and molecular mechanisms that sustain apoptosis resistance and fibrotic prog...