Correlation study of LINC02609 and SNHG17 as prognostic biomarkers of kidney renal clear cell carcinoma and therapeutic sensitivity based on public data and In Vitro analysis [0.03%]
基于公共数据和体外分析的LINC02609和SNHG17与肾透明细胞癌预后及治疗敏感性关联研究
Chaoqun Xing,Weiwei Zou,Yangqin Li et al.
Chaoqun Xing et al.
Background: Cuprotosis, a newly identified form of regulated cell death, has emerged as a potential therapeutic target for cancers. Kidney renal clear cell carcinoma (KIRC) is frequently metastatic at diagnosis, resulting...
Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification [0.03%]
基于生物信息学和实验验证鉴定出Grb2蛋白可能作为急性胰腺炎中巨噬细胞活化的介导者
Qinhao Shen,Shuai Wang,Keyan Wu et al.
Qinhao Shen et al.
Introduction: Macrophage activation is closely associated with Acute pancreatitis (AP). We screened and found that Growth factor receptor bound protein 2 (Grb2) is highly expressed in macrophages during AP. However, the r...
The real-world safety of Nivolumab: a pharmacovigilance analysis based on the FDA adverse event reporting system [0.03%]
基于美国食品药品监督管理局不良事件报告系统评价纳武利尤单抗真实世界安全性：药物流行病学分析
Yutong Wu,Yue Zhou,Shiyue Xia et al.
Yutong Wu et al.
Background: Nivolumab, a human immunoglobulin IgG4 monoclonal antibody targeting PD-1 receptor, received initial FDA approval in 2014 for treating unresectable or metastatic malignant melanoma (MM), followed by approval f...
Aberrant glycosylation patterns as potential biomarkers for diagnosis and disease progression in bullous pemphigoid [0.03%]
自身免疫性大疱病天疱疮的糖链异常及其作为生物标志物的潜在价值
Haijun Miao,Jundan Yang,Yaxing Bai et al.
Haijun Miao et al.
Objectives: Bullous pemphigoid (BP) is a prototypical autoimmune disease characterized by the production of autoantibodies against hemidesmosomal proteins BP180 and BP230. Aberrant glycosylation has emerged as a possible ...
GSDMD is a novel predictive biomarker for immunotherapy response: in the pan-cancer and single cell landscapes [0.03%]
GSDMD是免疫治疗反应的新型预测性生物标志物：泛癌和单细胞景观分析
Li Juan Huang,Feng Chen,Lin Chen et al.
Li Juan Huang et al.
Background: Gasdermin D (GSDMD), a key executor of pyroptosis, has been implicated in modulating the tumor immune microenvironment. However, its role as a predictive biomarker for immunotherapy response remains unclear. ...
Demographic characteristics and disease severity associated with IgA/IgG deposition patterns in autoimmune bullous diseases: a cohort study based on a registry database [0.03%]
自身免疫性大疱病患者IgA/IgG沉积模式相关的临床特征和疾病严重程度：基于登记数据库的队列研究
Jishu Li,Xun Feng,Mi Wang et al.
Jishu Li et al.
Background: Direct immunofluorescence (DIF) microscopy is the gold standard for diagnosing autoimmune bullous diseases (AIBDs), but the clinical significance of IgA and IgG co-deposition was unclear. ...
Rab7 inhibitor enhances stem cell differentiation into keratinocyte-like cells with anti-inflammatory properties [0.03%]
Rab7抑制剂可促进多能干细胞向具有抗炎作用的类角质细胞分化
Raghad Alghazali,Mouna Tabebi,Moustafa Elmasry et al.
Raghad Alghazali et al.
Management of difficult-to-heal skin wounds presents a significant clinical challenge, particularly when associated with inflammatory skin disorders. The differentiation of stem cells into keratinocyte-like cells has been explored as a pote...
Enhancing tofacitinib's therapeutic efficacy in murine arthritis with a synbiotic formulation comprising Bacillus megaterium DSM 32963 and an Omega-3 fatty acid lysine salt [0.03%]
以mega-spore生物制剂和欧米伽-3多聚体赖氨酸盐增强托法替尼在小鼠关节炎中的治疗效果
Annette Zehrer,Alexandra Rausch,Paul M Jordan et al.
Annette Zehrer et al.
Introduction: Omega-3 polyunsaturated fatty acids (n3-PUFA) are known for their anti-inflammatory benefits, particularly in chronic conditions like rheumatoid arthritis (RA). To resolve an acute inflammation, conversion o...
Immunotherapy of small cell lung cancer based on prognostic nutritional index [0.03%]
基于预后营养指数的小细胞肺癌免疫治疗
Xinling Zhang,Yaxuan Zhang,Jiaqi Zhang et al.
Xinling Zhang et al.
Platinum-based first-line chemotherapy for small lung cancers has been a mainstream therapy for the past several decades. However, its efficacy has been suboptimal, and the research is now focused on improving the treatment and prognosis of...
Role of tumor mutational burden in patients with urothelial carcinoma treated with immune checkpoint inhibitors: a systematic review and meta-analysis [0.03%]
程序性死亡配体1免疫检查点抑制剂治疗尿路上皮癌患者中肿瘤突变负荷的作用：系统评价和Meta分析
Zhe Wang,Danxue Huang,Su Li et al.
Zhe Wang et al.
Background: The predictive value of tumor mutation burden (TMB) on the efficacy of immunotherapy has been confirmed in multiple cancer types in previous studies. For urothelial carcinoma (UC) patients treated with immune ...