Expansion of CD57+ CD8 T cells in common variable immunodeficiency with hepatopathy and CMV infection [0.03%]
肝病和CMV感染的常见变量免疫缺陷中CD57+CD8 T细胞的扩增
Patrick Bez,Enrico Santangeli,Sigune Goldacker et al.
Patrick Bez et al.
Background: Common variable immunodeficiency (CVID) is associated with an altered immune homeostasis affecting many T-cell subpopulations, including an increased proportion of CD57+ CD8 T lymphocytes. This expansion has b...
Endogenous SLPI contributes to the regulation of inflammatory responses in peritoneal macrophages by modulating MMP-9 production [0.03%]
内源性SLPI通过调节MMP-9的产生来参与腹腔巨噬细胞炎症反应的调控
Mariia Tyshchenko,Natalia Pocałuń,Patrycja Kwiecińska et al.
Mariia Tyshchenko et al.
Secretory leukocyte protease inhibitor (SLPI) is described as a potent regulator of inflammation and tissue homeostasis with pleiotropic functions. It has been shown to inhibit pro-inflammatory responses in myeloid cells. However, its expre...
Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1-STAT3 signaling [0.03%]
鸸鹋emr-10a-5p通过干扰素介导的jak1-stat3信号抑制小鼠哮喘源性巨噬细胞m2a极化以减轻气道炎症
Yunzhuo Xin,Rou Wen,Dong Song et al.
Yunzhuo Xin et al.
Introduction: Parasites and parasite-derived extracellular vesicles (EVs) and microRNAs (miRNAs) can protect against inflammatory diseases, such as asthma. M2a macrophages facilitate the development of allergic asthma. mi...
Hanyu Liu,Lu Liu,Yuheng Zhang et al.
Hanyu Liu et al.
Traditionally, the role of lymphatic vessels has been understood as primarily involving fluid transport and immune surveillance. In addition to these roles, recent studies have revealed a paracrine function of lymphatics through the dissemi...
Haiqing Zeng,Zedongfang Yuan,Run-Tian Wu et al.
Haiqing Zeng et al.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation, joint injury, and deformity in the limbs. This disease is widely distributed, with a large number of patients, and there is a possibility of further ...
Harnessing delta-like ligand 3: bridging biomarker discovery to next-generation immunotherapies in refractory small cell lung cancer [0.03%]
利用δ样配体3：在难治性小细胞肺癌中从生物标志物发现到下一代免疫治疗
Kangkang Ji,Lin Guo,Dianbao Zuo et al.
Kangkang Ji et al.
Small cell lung cancer (SCLC), accounting for 10-20% of lung cancers, remains one of the most aggressive neuroendocrine malignancies, with fewer than 7% of patients surviving beyond five years. While the addition of immune checkpoint inhibi...
Integrated transcriptomic and microbiomic analyses reveal mechanisms of Decapod iridescent virus 1 resistance in Macrobrachium rosenbergii [0.03%]
整合转录组和微生物组分析揭示了凡纳滨对DFV-1的抵抗力机制
Jingwen Hao,Yukun Jie,Zhibin Lu et al.
Jingwen Hao et al.
Selective breeding for DIV1-resistant Macrobrachium rosenbergii is an effective strategy to mitigate aquaculture losses; however, the underlying resistance mechanisms remain poorly understood. In this study, approximately 2,300 prawns from ...
Case Report: BCMA-targeting CAR T-cell therapy induces complete and durable remission in relapsed extramedullary plasmablastic multiple myeloma [0.03%]
案例报告：靶向BCMA的CAR-T细胞治疗使多发性骨髓瘤复发病变得到完全且长期的缓解
Lili Zhou,Paul Ning Man Cheng,Jian-Qing Mi
Lili Zhou
Plasmablastic multiple myeloma (PBM) is an aggressive multiple myeloma (MM) form, identified by a high risk of recurrence and poor prognosis, with limited effective treatment options. Present study reports a case initially diagnosed with Ig...
Yue Liu,Xintao Tian,Chunyan Jia et al.
Yue Liu et al.
Atherosclerosis (AS), as the primary pathological basis of cardiovascular and cerebrovascular diseases, is closely associated with chemokines in its occurrence and progression. CXCL16 establishes a new link between chemokines and AS. We bri...
Synergistic chemotherapy and immunomodulatory effects of Quercetin in cancer: a review [0.03%]
天然产物槲皮素的抗癌化学和免疫调节效应综述
Hongyang Deng,Fengxian Wei,Wei Han et al.
Hongyang Deng et al.
Cancer is a significant public health problem worldwide, and its morbidity and mortality are challenging to improve, which is an important obstacle to prolonging life expectancy. Cytotoxic drugs have been used in anti-cancer therapy since t...