The HL-60 clone 15 cell line as a model for leukocyte migration-possibilities and limitations [0.03%]
HL-60克隆15细胞系作为白细胞迁移模型的作用和局限性
Lena Griesbaum,Christopher Weusthof,Thorben Sauer et al.
Lena Griesbaum et al.
Introduction: As a part of the innate immune system, eosinophils are recruited during infectious diseases, to release their characteristic cytotoxic granules and catch pathogens in extracellular traps. Moreover, eosinophi...
Malignant epithelial cell marker-driven risk signature enables precise stratification in esophageal cancer [0.03%]
恶性上皮细胞标记驱动的风险特征可使食管癌的精确分层成为可能
Hao Zhang,Shizhao Cheng,Yijun Xu
Hao Zhang
Background: Esophageal squamous cell carcinoma (ESCC) is a highly heterogeneous malignancy. Traditional clinical staging systems have limited value in prognostic evaluation and treatment guidance, often failing to capture...
Peptide based vesicles for cancer immunotherapy: design, construction and applications [0.03%]
基于肽的囊泡在癌症免疫治疗中的设计、构建及应用研究
Yulin Yu,Jiaxin Lyu,Yizimujiang Muhadaisi et al.
Yulin Yu et al.
Cancer immunotherapy has emerged as a powerful strategy for clinical treatment of malignant cancers. Despite the advances, cancer immunotherapy has met several challenges such as the limited efficacy to small subsets of patients, and seriou...
Integrative genomic and single-cell framework identifies druggable targets for colorectal cancer precision therapy [0.03%]
整合基因组和单细胞框架识别结直肠癌精准治疗的药物靶点
Yanggang Hong,Jiajun Li,Nuo Xu et al.
Yanggang Hong et al.
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Despite therapeutic advances, there is a critical need to identify novel, effective, and safe drug targets to improve prec...
Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation [0.03%]
探究线粒体代谢和免疫浸润在心肌梗死中的作用：生物信息学和实验验证的新见解
Jingyi Hou,Lihan Wang,Naiqiang Zhu et al.
Jingyi Hou et al.
Background: Mitochondrial metabolism and immune inflammation play pivotal roles in the MI pathogenesis of myocardial infarction (MI); however, their interplay remains unclear. This study aimed to clarify the roles of mito...
Phosphatidylglucoside regulates apoptosis of human neutrophilic lineage cells [0.03%]
磷糖脂酰胆碱调节人中性粒细胞谱系细胞的凋亡
Noriko Yokoyama,Roudy Chiminch Ekyalongo,Madoka Kage et al.
Noriko Yokoyama et al.
Apoptosis plays a fundamental role in the regulation of immune responses mediated by neutrophils. Phosphatidylglucoside (PtdGlc), a glycosylated phospholipid abundantly expressed on the surface of human neutrophils, has been implicated in p...
mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney [0.03%]
mTOR促进肾脏三级淋巴组织的形成和生长
Daniel J Atwood,Zhibin He,Makoto Miyazaki et al.
Daniel J Atwood et al.
Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues that form de novo in nonlymphoid organs. In this study, we demonstrate that the kidneys of aged mice with a renal tubule-specific knockout of autophagy-related 7 (Atg7) contain n...
Upadacitinib for refractory Behçet's disease with myelodysplastic syndrome and trisomy 8/9: a case report and mechanistic insights [0.03%]
乌帕替尼治疗难治性贝赫切特病合并骨髓增生异常综合征和8/9三体：病例报告及机制洞察
Yukai Wang,Feng Tian,Hui Li
Yukai Wang
Background: Behçet's disease (BD), a multisystemic inflammatory disorder with genetic predisposition, is frequently complicated by myelodysplastic syndrome (MDS), particularly in cases harboring trisomy 8. Patients with ...
Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine [0.03%]
基于机器学习的乳腺癌诊断和预后模型：自然杀伤细胞相关基因特征在精准医疗中的临床应用新前沿
Yutong Fang,Rongji Zheng,Yefeng Xiao et al.
Yutong Fang et al.
Background: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activi...
Telitacicept as double-targeted therapy for myasthenia gravis coexisting with connective tissue disease: three case reports [0.03%]
特利西普治疗与结缔组织病共存的重症肌无力的双靶点疗法：3例报告
Yingying Yang,Ying Zhu,Ruixia Zhu
Yingying Yang
Myasthenia gravis (MG) and connective tissue diseases (CTD) are both B-cell-mediated, antibody-associated autoimmune diseases that share similar mechanisms of immune dysfunction. The coexistence of MG and CTD is a rare phenomenon, and its m...