Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq [0.03%]
线粒体自噬相关生物标志物在重症急性胰腺炎中鉴定：WGCNA、机器学习算法和单细胞测序的整合分析
Xiaozhou Xie,Zheng Wang,Haoyu Zhang et al.
Xiaozhou Xie et al.
Background: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, t...
Dupilumab treatment has no effect on the nasal microbiome in patients with NSAID-exacerbated respiratory disease: a longitudinal pilot study [0.03%]
杜普利尤单抗治疗不影响鼻用糖皮质激素加重的呼吸系统疾病患者的鼻微生物群：一项纵向试点研究
Tina Bartosik,Petra Pjevac,Joana Séneca et al.
Tina Bartosik et al.
Background: Non-steroidal anti-inflammatory drugs-exacerbated respiratory disease (N-ERD) affects up to 10% of patients suffering from nasal polyps and has a severe impact on quality of life. Dupilumab, a monoclonal antib...
PD-1 is conserved from sharks to humans: new insights into PD-1, PD-L1, PD-L2, and SHP-2 evolution [0.03%]
从鲨鱼到人类的PD-1保守性：PD-1、PD-L1、PD-L2和SHP-2进化的最新见解
Ryohei Kondo,Kohei Kondo,Kei Nabeshima et al.
Ryohei Kondo et al.
Programmed cell death protein 1 (PD-1) is an immune checkpoint molecule until recently believed to exist only in tetrapod species. However, together with a very recent study dedicated to the CD28/CTLA4 molecule family, this study-using data...
Plasmapheresis for refractory toxic epidermal necrolysis unresponsive to conventional therapy: a case report and literature review [0.03%]
难治性中毒性表皮坏死松解症的传统治疗无效时血浆置换的疗效：病例报告及文献复习
Shun-Qi Liao,Zhang-Rong Yan,Lun-Wei Lin et al.
Shun-Qi Liao et al.
Toxic epidermal necrolysis (TEN) is a rare and life-threatening severe cutaneous adverse reaction. The conventional treatment approach includes immunomodulatory therapies, such as systemic corticosteroids, cyclosporine, intravenous immunogl...
Baseline type 2 biomarker levels and clinical remission predictors in children with asthma [0.03%]
基线下的第二种生物标志物水平和儿童哮喘临床缓解预测因素
Mengmeng Chen,Congcong Li,Qiuyan Yang et al.
Mengmeng Chen et al.
Background: Few studies have investigated the relationship between baseline type 2 biomarker levels and clinical features in pediatric asthma, particularly in different asthma stages, which may inform prognosis and remiss...
Exploring the role of neutrophils in inflammatory pain hypersensitivity via single-cell transcriptome profiling [0.03%]
通过单细胞转录组学揭示中性粒细胞在炎症痛敏中的作用
Kai Ding,Xing Liu,Bin Zeng et al.
Kai Ding et al.
Introduction: Myeloid CD11b+ cells are crucial mediators in post-operative and CFA-induced inflammation, but their role in pain, particularly the role of neutrophils, is still debated. This study employs single-cell RNA s...
Heterologous prime-boost vaccination drives stromal activation and adaptive immunity against SARS-CoV-2 variants [0.03%]
异源初免加强接种疫苗可驱动针对SARS-CoV-2变异株的基质活化和适应性免疫反应
Ji Hyang Jeon,Seongryong Kim,Seo-Yeon Kim et al.
Ji Hyang Jeon et al.
Heterologous vaccination strategies have shown superior efficacy over homologous regimens in clinical studies, but the underlying immunological mechanisms remain incompletely understood. Using a mouse model, we investigated the immune respo...
Dendritic cell-derived exosomes as anti-cancer cell-free agents: new insights into enhancing immunogenic effects [0.03%]
树突细胞源外泌体作为抗癌无细胞制剂：增强免疫原性的新思路
Tikhon Redkin,Victoria Turubanova
Tikhon Redkin
The secretome of immune cells is currently a major focus in both diagnostic and therapeutic contexts. Cell-free therapeutic agents attract even more attention in cancer immunotherapy research, as their properties are comparable to, and some...
T cell exhaustion in pediatric B-ALL: current knowledge and future perspectives [0.03%]
儿童B-ALL中T细胞衰竭：当前的认识和未来展望
Tanmaya Atre,Gregor S D Reid
Tanmaya Atre
B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy, accounting for 20-25% of all new cancer diagnoses in North American children each year. The leukemia arises, most commonly after a latency of 3-5 years, fr...
Autophagy crosstalk with the immune microenvironment in chronic myeloid leukemia and serves as a biomarker for diagnosis and progression [0.03%]
慢性粒细胞白血病中自噬与免疫微环境互作及其作为诊断和预后标志物的作用研究
Fangmin Zhong,Fangyi Yao,Jing Liu et al.
Fangmin Zhong et al.
Background: Previous studies have shown that autophagy is closely related to the occurrence, development, and treatment resistance of chronic myeloid leukemia (CML) and has dual roles in promoting cell survival and induci...