Wei Chen,Afang Zhou,Yunfeng Zhou
Wei Chen
Lung cancer is a refractory malignancy. Although various therapeutic options, including targeted therapies, immune checkpoint inhibitors, and systemic chemotherapy, have significantly improved the prognosis of lung cancer patients, five-yea...
Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases [0.03%]
单细胞转录组揭示神经疾病脑脊液免疫特征
David Ramos-Vicente,Paola Monterosso,Oriol de Fàbregues et al.
David Ramos-Vicente et al.
In this comprehensive review, we delve into the significant body of research on single-cell transcriptomics in cerebrospinal fluid (CSF) to understand neurological diseases with autoimmune, neurodegenerative, infectious, or oncogenic origin...
Patrolling monocytes mediate virus neutralizing IgG effector functions: beyond neutralization capacity [0.03%]
巡逻单核细胞介导病毒中和IgG效应功能：超越中和能力
Abdelrahman Elwy,Swati Dhiman,Hossam Abdelrahman et al.
Abdelrahman Elwy et al.
Neutralizing antibodies (nAbs) are pivotal in developing fast, broadly protective therapeutics against novel pandemic viruses. Despite their well-known direct neutralization capacity, their effector mechanisms via Fc receptors remain poorly...
Causal relationship between hepatic function indicators and thrombocytopenia risk in early-stage hepatitis B virus infection: evidence from clinical observational studies and mendelian randomization analyses [0.03%]
临床观察研究和孟德尔随机化分析提供证据：乙肝病毒感染早期肝功能指标与血小板减少风险存在因果关系
Tian-Bin Chen,Jian-Wei Jiang,Hong-Yan Guo et al.
Tian-Bin Chen et al.
Background: Thrombocytopenia is a common occurrence in patients with hepatitis B virus (HBV) infection, particularly in those with liver cirrhosis. However, it can also manifest in the early stages of HBV infection, befor...
Observational Study
Frontiers in immunology. 2025 May 29:16:1440317. DOI:10.3389/fimmu.2025.1440317 2025
Identification and validation of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration [0.03%]
椎间盘退变中细胞衰老相关基因及免疫细胞浸润特征的识别与验证
Hao Li,Lei Miao,Jiayuan Wu et al.
Hao Li et al.
Objective: To identify cell senescence-related genes and immune cell infiltration characteristics in intervertebral disc degeneration (IVDD) using bioinformatics and investigate their biological functions and signaling pa...
A nomogram for predicting unfavorable outcomes of antituberculosis treatment among individuals with AIDS combined with pulmonary tuberculosis in China [0.03%]
中国艾滋病合并肺结核患者抗结核治疗不良结局预测 nomogram
Xiaoxu Han,Jin Sun,Yuan Gao et al.
Xiaoxu Han et al.
Background: Acquired Immune Deficiency Syndrome (AIDS) combined with tuberculosis (TB) is one of the key factors affecting global TB control, and timely and effective treatment is essential to improve the prognosis in thi...
T lymphocyte heterogeneity in NSCLC: implications for biomarker development and therapeutic innovation [0.03%]
非小细胞肺癌中T淋巴细胞异质性与生物标志物研发及治疗创新的关系
Yu Liu,Denghui Qin,Jiejun Fu
Yu Liu
Non-small cell lung cancer (NSCLC) immunotherapy has been revolutionized by immune checkpoint inhibitors (ICIs), yet response heterogeneity persists due to dynamic tumor-immune interactions. This review summarizes recent studies in understa...
The landscape and clinical impact of tumor-associated macrophages and PD-L1 in primary breast cancers and their brain metastases [0.03%]
原发性乳腺癌及其脑转移灶中肿瘤相关巨噬细胞和PD-L1的临床及影像学影响
Yannik Nicola Zimmer,Benjamin Hanke,Belal Neyazi et al.
Yannik Nicola Zimmer et al.
Background: Tumor-associated macrophages (TAMs) influence the tumor microenvironment and can contribute to tumor progression. They can polarize into M1 (classically activated) or M2 (alternatively activated) phenotype, wh...
Corrigendum: Characterization of TLR9 responsiveness in cell subsets derived from in vitro pDC differentiation of hematopoietic stem and progenitor cells [0.03%]
更正：造血干细胞和祖细胞向体外分化获得的树突状细胞亚群中TLR9反应性的特征分析
Sabina Sánchez Hernández,Tobias Wang Bjerg,Ian Helstrup Nielsen et al.
Sabina Sánchez Hernández et al.
[This corrects the article DOI: 10.3389/fimmu.2025.1550397.]. Keywords: CD34 hematopoietic stem cells; in vi...
Published Erratum
Frontiers in immunology. 2025 May 29:16:1625107. DOI:10.3389/fimmu.2025.1625107 2025
Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models [0.03%]
动物模型中，抑制溶菌酶1改善代谢紊乱并恢复稳态失调
Katarzyna Drzewicka,Katarzyna M Głuchowska,Michal Mlącki et al.
Katarzyna Drzewicka et al.
Background: OATD-01 is a chitinase-1 (CHIT1) inhibitor, reducing inflammation and fibrosis in animal models where chronic inflammation leads to tissue remodeling. CHIT1, predominantly secreted by macrophages, is overexpre...