Harnessing NKG2D CAR-T cells with radiotherapy: a novel approach for esophageal squamous cell carcinoma treatment [0.03%]
放疗协同NKG2D CAR-T细胞治疗食管鳞癌的新策略研究
Tianyu Liu,Liyuan Fan,Weicheng Huang et al.
Tianyu Liu et al.
Background: Esophageal squamous cell carcinoma (ESCC) represents a highly aggressive malignancy with poor prognosis and limited therapeutic advancements. While chimeric antigen receptor (CAR)-T-cell therapy has revolution...
Identification of diagnostic genes for myocardial ischemia reperfusion injury associated with metabolic syndrome through the integration of bioinformatics analysis, molecular docking and experimental validation [0.03%]
通过生物信息学分析、分子对接和实验验证整合识别代谢综合征相关的心肌缺血再灌注损伤的诊断基因
Shufang Liu,Yan Zhang,Yanan Zhao et al.
Shufang Liu et al.
Background: Metabolic dysregulation in metabolic syndrome (MetS) exacerbates myocardial ischemia-reperfusion injury (MIRI). This study aimed to identify diagnostic biomarkers and therapeutic candidates for MetS-associated...
Global hotspots and trends in pre-metastatic niche research: a bibliometric analysis(2005-2024) [0.03%]
2005-2024年预转移龛研究的全球热点和趋势计量学分析
Mengqi Cheng,Qianhui Sun,Hua Duan et al.
Mengqi Cheng et al.
Background: The pre-metastatic niche (PMN) represents the microenvironment established in target organs before primary tumor metastasis, playing a crucial role in organ-specific metastasis. Understanding and preventing PM...
Dynamic alterations of circulating lymphocytes during the trajectory of Hantaan virus-induced hemorrhagic fever with renal syndrome [0.03%]
汉坦病毒引起的肾综合征出血热病程中循环淋巴细胞的动态变化
Lin Su,Shuangjuan Liu,Lei Shi et al.
Lin Su et al.
Introduction: Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease with high mortality. Almost 90% of global cases of HFRS are induced by Hantaan virus (HTNV) infection. Although lymphocyte dysfunction is a ...
Integrated multi-omics analysis and experimental investigation of mitochondrial dynamics-related genes: molecular subtypes, immune landscape, and prognostic implications in lung adenocarcinoma [0.03%]
整合的多组学分析和实验调查与线粒体动力学相关基因的研究：分子亚型、免疫图谱及在肺腺癌预后中的意义
Sixuan Wu,Junfan Pan,Lijun Zeng et al.
Sixuan Wu et al.
Background: Lung adenocarcinoma (LUAD) is a common and aggressive subtype of lung cancer associated with poor clinical outcomes. The role of mitochondrial dynamics (MD)-related genes in tumor progression and immune regula...
Key indicators for guiding tocilizumab therapy to prevent orbital decompression surgery in hormone-resistant dysthyroid optic neuropathy [0.03%]
托珠单抗治疗以预防激素抵抗性突眼型甲状腺眼病视神经病变眶减压手术的关键指标
Wenjun Shu,Mingxu Yan,Lu Gan et al.
Wenjun Shu et al.
Introduction: Tocilizumab (TCZ) has been demonstrated to be effective in treating thyroid-associated ophthalmopathy (TAO); however, its efficacy in hormone-resistant dysthyroid optic neuropathy (DON) remains unclear. This...
A question of TiME: how microenvironmental interactions shape response to immunotherapy in CLL and Richter Transformation [0.03%]
TiME的问题：微环境相互作用如何影响CLL和里德尔转化的免疫治疗反应
Alexander F Vom Stein,Phuong-Hien Nguyen,Elisa Ten Hacken
Alexander F Vom Stein
Immunotherapy has revolutionized the treatment landscape for many cancers, including some B- cell lymphomas. Immune checkpoint blockade, CAR-T cells and bispecific antibodies have shown promise for the treatment of Richter Transformation (R...
Drug repurposing of fostamatinib against cancer via potential cytotoxicity and immune checkpoint regulation [0.03%]
福斯他替尼通过潜在细胞毒性和免疫检查点调节来重新定位用于癌症治疗
Maoqiong Hu,Renyi Yin,Kaifeng Deng et al.
Maoqiong Hu et al.
Acute myeloid leukemia (AML), originating from myeloid hematopoietic stem/progenitor cells, is a malignant hematological disorder. Resistance to current treatments, especially in FLT3-ITD AML cases, urgently demands the development of novel...
The efficacy and safety of regorafenib/fruquintinib combined with PD-1/PD-L1 for metastatic colorectal cancer: a meta-analysis based on single-arm studies [0.03%]
瑞戈非尼/呋喹替尼联合PD-1/PD-L1治疗转移性结直肠癌的疗效和安全性：基于单臂研究的Meta分析
Fan Yang,Ying Mao,Hanyu Huang et al.
Fan Yang et al.
Objective: The efficacy of regorafenib or fruquintinib in combination with PD-1/PD-L1 inhibitors for metastatic colorectal cancer (mCRC) treatment has not been elucidated. This study aims to systematically evaluate the ef...
Multi-physiology modeling of the immune system in the era of precision immunotherapy [0.03%]
精确免疫治疗时代的免疫系统多生理建模
Sunghyun Hong,Kyemyung Park
Sunghyun Hong
Immunotherapies using new modalities, including antibody-based drugs, nanoparticle-delivered drugs, and adoptive cell therapy, have become major treatment options for immune-related diseases such as cancer, autoimmune diseases, and infectio...