Wei Li,Ao Ren
Wei Li
Liver transplantation is a life-saving treatment for end-stage liver disease, but long-term outcomes are limited by complications of lifelong immunosuppression. Inducing immune tolerance has become a major research priority. Tryptophan (Trp...
Cannabidiol selectively attenuates lipotoxic immunometabolic inflammation in human macrophages [0.03%]
大麻二酚选择性地抑制人体巨噬细胞脂毒性免疫代谢炎症
Mayte Rueda-Munguía,Roberto Rodriguez-Moncayo,Luis Alberto Luévano-Martínez et al.
Mayte Rueda-Munguía et al.
The role of saturated fatty acid-induced immunometabolic stress in macrophage dysfunction during metabolic disease remains incompletely understood, particularly the interplay between inflammatory signaling and intracellular lipid handling. ...
Systemic and mucosal immunity to enterotoxigenic Escherichia coli: evidence from natural infection and vaccination [0.03%]
肠毒素性大肠杆菌的全身免疫和粘膜免疫：来自自然感染和疫苗接种的证据
Cynthia Mubanga,Masauso Moses Phiri,Kapambwe Mwape et al.
Cynthia Mubanga et al.
Enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal morbidity and mortality, especially among children under 5 years of age in low- and middle-income countries (LMICs). Development of an effective ETEC vaccine has be...
The type 1 and type 3 immune responses underlying the tissue inflammation associated with NOX2 deficiency [0.03%]
NOX2缺陷相关的组织炎症背后的1型和3型免疫反应
Wan-Ting Cheng,Miao-Shan Lin,Tzu-Yi Chan et al.
Wan-Ting Cheng et al.
Phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) is the primary source of reactive oxygen species (ROS) in leukocytes for host defense and immune signaling. Loss-of-function mutations in NOX2 leads to chronic gr...
From Modic changes to the disc-endplate-bone marrow complex: imaging stratification, immune remodeling, and translational implications in intervertebral disc degeneration [0.03%]
从Modic改变到椎间盘-终板-骨髓复合体：腰椎间盘退变的影像分层、免疫重建和转化意义
Yang Liu,Hua Huang,Maoqiang Lin et al.
Yang Liu et al.
Intervertebral disc degeneration (IVDD) is frequently implicated in low back pain (LBP), yet the severity of degeneration on imaging often fails to parallel pain intensity or functional limitation. Modic changes capture abnormal marrow sign...
Fraxinellone mitigates acute lung injury by targeting HIF-1α to suppress pyroptosis and inflammation [0.03%]
巴豆酸内酯通过靶向HIF-1α抑制急性肺损伤中的焦亡与炎症反应
Bing Zhang,Xiaoning Lu,Yuefei Zhang et al.
Bing Zhang et al.
Purpose: Acute pulmonary contusion (APC), a life-threatening trauma-associated condition, currently lacks targeted pharmacological therapies. Fraxinellone (FRA) inhibits Hypoxia-inducible factor-1α (HIF-1α) synthesis, b...
Gastrointestinal acute graft versus host disease: a translational perspective from pathogenesis to precision prevention and treatment [0.03%]
胃肠急性移植物抗宿主病：从发病机制到精准防治的转化视角
Zhengwei Tan,Jinyu Hu,Baodong Ye et al.
Zhengwei Tan et al.
Allo-HSCT represents a curative option for various hematological disorders. However, aGVHD remains the leading cause of non-relapse mortality following transplantation. The gastrointestinal tract is the most severely affected and prognostic...
Case Report: From chronic infection to disseminated strongyloidiasis: a case of corticosteroid-induced hyperinfection syndrome [0.03%]
个案报告：从慢性感染到广泛性强แiasm病：一例皮质类固醇诱导的过度感染综合征病例
Yingying Lu,Jiaqi Su,Yinping You et al.
Yingying Lu et al.
Background: Strongyloides stercoralis (S. stercoralis) is a soil-transmitted nematode predominantly endemic to tropical and subtropical regions, capable of causing life-threatening hyperinfection syndrome and disseminated...
Perioperative substance P/NK1R pharmacology: from PONV control to a testable cancer neuro-immune hypothesis [0.03%]
围手术期物质P/NK1受体药理学：从术后恶心呕吐控制到可检验的癌症神经免疫假设
Jing Zhao,Zhongwei Liu,Jun Wang
Jing Zhao
The perioperative period is increasingly recognized as a biologically active interval in which surgical injury, anesthetic exposure, neuroendocrine stress, pain, opioid use, and innate immune remodeling may influence residual tumor-cell eco...
Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis [0.03%]
能量危机与软骨塌陷：骨关节炎中软骨细胞的代谢重编程
Fangzheng Yang,Qi Wang,Xuesai Zhu et al.
Fangzheng Yang et al.
Osteoarthritis (OA), a degenerative joint disease imposing a significant global disease burden, exhibits pathological mechanisms far more complex than mere "cartilage wear". Previous research has long centered on mechanical wear of articula...