Case Report: Multimodal management of duodenal metastasis from hepatocellular carcinoma complicated by intractable hemorrhage [0.03%]
个例报告：多模式治疗肝细胞癌十二指肠转移并发顽固性出血病例
Xin Zhang,Zhongsong Gao,Jiao Wang et al.
Xin Zhang et al.
Hepatocellular carcinoma with duodenal involvement is a rare clinical entity with limited treatment options. Here, we report a case of advanced hepatocellular carcinoma and portal vein tumor thrombus with metastatic involvement of the duode...
Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity [0.03%]
LIPG-384A/C启动子变异通过免疫遗传调节内皮炎症影响COVID-19的严重性
HariOm Singh,Aishwarya Nair,Meenakshi Bhattacharya et al.
HariOm Singh et al.
Background: Severe COVID-19 is characterized by dysregulated host immune responses and immune-mediated endothelial injury, culminating in microvascular dysfunction and systemic inflammation. Endothelial lipase (EL), encod...
Bovine natural killer cell subsets can be defined by differential expression of CD161 (KLRB1) [0.03%]
牛自然杀伤细胞亚群可以通过差异表达CD161（KLRB1）来定义
Inga Dry,Marta Kalandadze,Zhiguang Wu et al.
Inga Dry et al.
Natural killer (NK) cells play a vital role in the immune response to infection, disease, and vaccination. Bovine NK cell subsets have been described; however, a more in-depth characterization is currently hindered by the lack of species-sp...
A predictive model for low-dose rituximab response in anti-acetylcholine receptor antibody-positive myasthenia gravis: establishment and validation [0.03%]
乙酰胆碱受体抗体阳性重症肌无力低剂量利妥昔单抗治疗反应的预测模型建立及验证
Chenlu Hou,Yifan Zhang,Xiangqi Cao et al.
Chenlu Hou et al.
Background: Rituximab (RTX) represents an established therapeutic option for myasthenia gravis refractory to conventional immunotherapy. However, its heterogeneous efficacy across populations creates a challenge in clinic...
Co-culture with fibroblasts in stiff 3D scaffolds increases CD54 and CD140a expression on macrophages [0.03%]
在刚性的三维支架中共培养的成纤维细胞可提高巨噬细胞上的CD54和CD140a表达量
Jennessa Wx Ng,Santosh Trb Rao,Emily H Field et al.
Jennessa Wx Ng et al.
Vascular fibrosis is a major contributor to hypertension and cardiovascular disease and is caused by excessive extracellular matrix deposition and tissue stiffening. Macrophages and fibroblasts are key regulators of this process, yet most s...
Meta-analysis and systematic review: the association between rheumatoid arthritis and the risk of thyroid cancer [0.03%]
meta分析和系统评价：类风湿关节炎与甲状腺癌风险的关系分析
Xue Li,Ruihan Liu,Yan Zhang et al.
Xue Li et al.
Background: Rheumatoid Arthritis (RA), as a common autoimmune disease, not only causes damage to the joints themselves, but also increases the risk of developing other diseases. In recent years, the association between RA...
A conditional multi-signal validation framework for cancer immunotherapy: the adaptive anti-error biological system [0.03%]
一种针对癌症免疫疗法的条件多信号验证框架：适应性抗错生物系统
Emery M Kalondero
Emery M Kalondero
Background: Cancer immunotherapy faces persistent limitations due to its reliance on single-signal therapeutic architectures, which are vulnerable to antigen loss, off-tumor toxicity, and tumor heterogeneity. A fundamenta...
Multi-layer transcriptomic analyses identify a mucin-associated epithelial program linked to innate inflammatory injury in ulcerative colitis [0.03%]
多层次转录组分析识别出与溃疡性结肠炎先天性炎症损伤相关的粘蛋白相关上皮细胞程序
Jianmin Huang,Jingui He,Haimin Li et al.
Jianmin Huang et al.
Epithelial barrier disruption and mucosal innate immune activation reinforce each other in ulcerative colitis (UC), yet the epithelial glycosylation programs linking mucus homeostasis to inflammatory tissue injury remain incompletely define...
From empirical treatment to precision intervention: a multi-database bibliometric analysis of neuropsychiatric systemic lupus erythematosus (2006-2025) [0.03%]
从经验治疗到精准干预：基于多数据库的神经精神狼疮文献计量分析（2006-2025年）
Maiheliya Baihetiyaer,Xingyu Zhu,Jiang-Shan Wu et al.
Maiheliya Baihetiyaer et al.
Objective: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe and complex complication of systemic lupus erythematosus that affects diagnostic decision-making and treatment strategies. However, the temporal...
Mitochondrial transfer in the tumor microenvironment: a dynamic determinant of cancer plasticity, immune dysfunction, and therapeutic opportunity [0.03%]
肿瘤微环境中线粒体转移：一种决定癌症可塑性、免疫功能障碍和治疗机会的动态因素
Zhenyuan Xu,Qingli Zhou,Jifei Miao
Zhenyuan Xu
Intercellular mitochondrial transfer has emerged as a significant mode of communication within the tumor microenvironment (TME). We propose that this process operates as a stress-adaptive organelle economy, redistributing three biologically...