Efficacy of BCMA CAR-T cell therapy and subsequent strategies in refractory and relapsed plasma cell leukemia: a retrospective cohort study [0.03%]
靶向BCMA的CAR-T细胞治疗及后续策略治疗难治和复发性浆细胞白血病的疗效：一项回顾性队列研究
Yuelu Guo,Lixia Ma,Fan Yang et al.
Yuelu Guo et al.
Background: Plasma cell leukemia (PCL) is a rare and aggressive hematological malignancy. The long-term prognosis of relapsed/refractory plasma cell leukemia (R/R PCL) remains poor, and few treatment options are available...
Lupus nephritis and its association with subclinical myocardial alterations in systemic lupus erythematosus assessed by cardiovascular magnetic resonance [0.03%]
狼疮性肾炎与系统性红斑狼疮患者亚临床心肌改变的相关性心血管磁共振评价
Zhi Yang,Ling-Li Wang,Tian-Yue Zhang et al.
Zhi Yang et al.
Background: Lupus nephritis (LN) is the most common and severe complication in patients with systemic lupus erythematosus (SLE) and is associated with cardiac disease. The purpose of this study was to assess the cardiac p...
Migratory vasodilatation of cerebral arteries in MELAS episodes: a case report and literature review [0.03%]
线粒体脑肌病伴乳酸血症和卒中样发作的血管舒张现象：病例报告及文献复习
Ying Luo,Quanhong Chu,Taochun Yu et al.
Ying Luo et al.
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is the commonest inherited mitochondrial disorder. Dilation of the major cerebral arteries is seldom mentioned in MELAS because magnetic resonance angiogr...
Sex hormone-psoriasis interactions: from sex-specific clinical features to immunoregulatory mechanisms [0.03%]
性激素与银屑病的相互作用：从性别特异性临床特征到免疫调节机制
Yingying Dai,Yuanting Wang,Yuwei Huang et al.
Yingying Dai et al.
Psoriasis is a chronic inflammatory skin disease mediated by T cells, characterized by distinct sex differences and variations across different reproductive stages, suggesting that sex hormones may play a significant role in its pathogenesi...
Global trends of peripheral immune tolerance research: a bibliometric and visualization analysis [0.03%]
外周免疫耐受研究的全球趋势分析：基于文献计量和知识图谱可视化研究
Shixiao Kong,Chen Lin,Yuting Shen et al.
Shixiao Kong et al.
Background: Peripheral immune tolerance is a key mechanism for maintaining immune homeostasis and preventing autoimmune responses. Although numerous studies have explored its molecular and cellular basis, a comprehensive ...
Immunomodulatory effects of oral microbiota in the pathogenesis of rheumatoid arthritis [0.03%]
口腔微生物群在类风湿性关节炎发病机制中的免疫调节作用
Yiming Yang,Guanyuan Wang,Yongzhou Song et al.
Yiming Yang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive cartilage and bone destruction, and resulting functional disability. Its pathogenesis is multifactorial, involving both...
Oncostatin M upregulates CD73 via the MAPK pathway in keratinocytes to promote an adenosine-dependent anti-inflammatory response in psoriasis [0.03%]
Oncostatin M通过MAPK通路在角质形成细胞中上调CD73以促进银屑病中的腺苷依赖性抗炎反应
Caterina Giraulo,Giacomo De Palma,Paola Plaitano et al.
Caterina Giraulo et al.
Introduction: Psoriasis is a chronic inflammatory skin condition driven by activated epidermal keratinocytes, dermal fibroblasts, and immune cell infiltrates, which causes tissue injury. The ecto-5'-nucleotidase CD73/aden...
Beyond inhaled medications: precision medicine and biologic therapies targeting the IL-33/TSLP/type 2 axis in COPD [0.03%]
超越吸入药物：针对慢阻肺IL-33/TSLP/2型信号通路的精准医疗和生物制剂疗法
Guo-Qiang Song,Bangsheng Chen,Tian-Li He et al.
Guo-Qiang Song et al.
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and chronic airway inflammation, traditionally managed with inhaled bronchodilators and corticosteroids. However, a significant subset of patient...
Myeloid-derived PD-L1 characterizes spatially organized immune architecture in colorectal cancer [0.03%]
髓样衍生的PD-L1表征了结直肠癌中的空间组织免疫结构
Qian Wu,Stephanie Tissot,Allyson Peddle et al.
Qian Wu et al.
Introduction: The tumor immune microenvironment (TIME) is highly heterogeneous and strongly influences immunotherapy outcomes and patient prognosis in colorectal cancer (CRC). In this exploratory study, we used three mult...
Dupilumab treatment outcomes in bullous pemphigoid: a systematic review and single-arm meta-analysis [0.03%]
杜普利尤单抗治疗大疱性天疱疮的疗效：系统评价和单臂型荟萃分析
Yudi Chen,Kailv Sun,Jianmin Chang
Yudi Chen
Background: Bullous pemphigoid (BP) is the most common autoimmune subepidermal bullous disease of the skin. Novel biologic agents represent a potential therapeutic option. We explore the use of dupilumab in the treatment ...