The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances [0.03%]
B细胞活化因子系统的自身免疫病作用机制、疾病相关性及治疗进展
Liang Li,Shengxian Shen,Shuai Shao et al.
Liang Li et al.
The B cell-activating factor (BAFF) system, comprising two ligands and three receptors, plays a pivotal role in adaptive and innate immunity, driving autoimmunity through dysregulated B and T cell survival, differentiation, and cytokine pro...
Culicoides allergens expressed in insect cells induce sulphidoleukotriene release from peripheral blood leukocytes of horses affected with insect bite hypersensitivity [0.03%]
昆虫细胞表达的库休埃虫过敏原可诱导马外周血白细胞释放硫化型白三烯
Sigridur Jonsdottir,Sara Björk Stefansdottir,Jelena Mirkovitch et al.
Sigridur Jonsdottir et al.
Introduction: Insect bite hypersensitivity (IBH) is an IgE-mediated dermatitis in horses caused by bites of Culicoides spp. The allergens are salivary gland proteins from these insects, and nine major allergens from Culic...
Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies [0.03%]
铁死亡与骨关节炎：代谢重编程、免疫代谢交叉对话及靶向干预策略
Shenglin Xia,Li Li,Zhexiong Shi et al.
Shenglin Xia et al.
Osteoarthritis is a common degenerative joint disease characterized by progressive cartilage loss, bone remodeling, and chronic joint inflammation, yet its underlying mechanisms remain incompletely understood. Disrupted iron metabolism, par...
Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation [0.03%]
G蛋白偶联受体信号在肺腺癌代谢重编程和免疫微环境中的作用及其多组学研究与实验验证
Zhaoxuan Wang,Cheng Wang,Shilei Zhao et al.
Zhaoxuan Wang et al.
Background: Lung adenocarcinoma (LUAD) is characterized by metabolic and immune heterogeneity, driving tumor progression and therapy resistance. While G protein-coupled receptors (GPCR) signaling is known to regulate meta...
Giorgia Fontana,Fabiana Ziberna,Egidio Barbi et al.
Giorgia Fontana et al.
Celiac disease is a widespread autoimmune enteropathy with a genetic predisposition triggered by gluten intake. The only available treatment is a strict lifelong gluten-free diet. The diagnosis is based on the detection of serum celiac dise...
Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses [0.03%]
新型冠状病毒感染的BMDCs的整体细胞响应：基于蛋白质组和转录组分析
Yanxi Ji,Yuzhen Zhang,Yongjia Tong et al.
Yanxi Ji et al.
Introduction: Understanding the intricacies of the host inflammatory response to coronaviruses is essential for developing effective therapeutic strategies to mitigate the severe consequences of these infections. Various ...
Case Report: Summary of multiple CAR-T expansions in anti-BCMA/GPRC5D bispecific CAR-T cell therapy for multiple myeloma [0.03%]
案例报告：多发性骨髓瘤双特异性BCMA/GPRC5D抗原CAR-T细胞治疗的多次扩增总结
Liya Wei,Xingxian Xiao,Xin Jing et al.
Liya Wei et al.
Chimeric antigen receptor (CAR) -T cell therapy targeting B-cell maturation antigen (BCMA) has demonstrated significant efficacy and is considered an ideal target for the treatment of relapsed or refractory multiple myeloma (R/R MM). Howeve...
Lymphocyte exhaustion in hepatocellular carcinoma: a dynamic evolution across disease stages [0.03%]
肝细胞癌的淋巴细胞耗竭：疾病各阶段的动态演变
Carla Fuster-Anglada,Josep Corominas,Aida Marsal et al.
Carla Fuster-Anglada et al.
Background: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy. However, their efficacy in hepatocellular carcinoma (HCC) is limited, highlighting the need to further explore immune microenvironments and ...
Biomarkers for diagnosis and prognosis of myelin oligodendrocyte glycoprotein antibody-associated disease - review article [0.03%]
髓鞘少突胶质细胞糖蛋白抗体相关疾病的诊断和预后生物标志物-综述文章
Tamang Sapana,Zhihong Zhuo
Tamang Sapana
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a complex inflammatory central nervous system disorder affecting mainly children and young adults. Its diverse clinical spectrum often resembles other neurological d...
Intramuscular DNA vaccine provides protection in non-human primate and mouse models of SARS-CoV-2 [0.03%]
肌肉注射型DNA疫苗可预防新冠病毒非人灵长类动物和小鼠模型感染
Subeena Sood,Ebony N Gary,Majed Matar et al.
Subeena Sood et al.
Nucleic acid vaccine approaches have proven successful in the context of the SARS-CoV-2 pandemic, however challenges with delivery remain. Here we describe PlaCCine, a DNA-based vaccine platform that utilizes a device- and vector-free chemi...