Maria Tada,Michihito Kono
Maria Tada
Immune cell metabolism is essential for regulating immune responses, including activation, differentiation, and function. Through glycolysis and oxidative phosphorylation (OXPHOS), metabolism supplies energy and key intermediates for cell g...
Cord blood innate-like T cell responses in neonates born to healthy women and women living with HIV [0.03%]
母亲健康状况与人免疫缺陷病毒阳性对新生儿脐血固有样T细胞应答的影响
David Rach,Hao-Ting Hsu,Nginache Nampota-Nkomba et al.
David Rach et al.
Innate-like T cells (ILT), including γδ T cells (Vδ2s), Natural Killer T cells (NKTs) and Mucosal-associated Invariant T cells (MAITs), integrate innate and adaptive immunity, playing important roles in homeostatic conditions as well as ...
Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions [0.03%]
创伤性脊髓损伤后微胶质细胞焦亡作为治疗靶点的最新研究进展及未来方向
Lei Shi,Qiheng Qian,Jiding Xie et al.
Lei Shi et al.
Traumatic spinal cord injury (TSCI) is a devastating neurological condition with limited therapeutic options and a high likelihood of permanent disability. Among the multifaceted secondary injury mechanisms triggered by TSCI, pyroptosis-an ...
4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells [0.03%]
辛基衣康酸缓解鼻粘膜上皮细胞氧化应激损伤
Hanna Steppuhn,Katja Hohenberger,Susanne Mittler et al.
Hanna Steppuhn et al.
Background and objective: Particulate matters such as diesel exhaust particles induce oxidative stress in cells and thereby have a negative impact on health. The aim of this study was to test whether the membrane-permeabl...
Pustular reaction in adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies [0.03%]
成人因抗干扰素-γ自身抗体导致免疫缺陷的脓疱反应
Narachai Julanon,Pojsakorn Danpanichkul,Charoen Choonhakarn et al.
Narachai Julanon et al.
Introduction: Cutaneous manifestations in adult-onset immunodeficiency (AOID) resulting from anti-interferon-gamma autoantibody (AIGA) are prevalent and can be classified into infective and reactive disorders. To date, no...
Aging-associated DNA methylation of LEF1 modulates inflammation and neurodegenerative pathways [0.03%]
年龄相关的LEF1甲基化调节炎症和神经退行性病变通路
Mengke Chen,Lujie Zhou,Yidan Gao et al.
Mengke Chen et al.
Background: Aging is accompanied by profound changes in immune regulation and epigenetic landscapes, yet the molecular drivers underlying these alterations are not fully understood. ...
A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028 [0.03%]
一项针对晚期实体瘤患者进行个体化新抗原肽疫苗与非传统放疗联合治疗的II期随机试验（iNATURE）-GCOG0028
Yan Zhang,Ye-Fan Hu,Lingyu Ma et al.
Yan Zhang et al.
Background: Neoantigen-based vaccines show promising therapeutic potential in solid tumors such as melanoma, GBM, NSCLC, and CRC. However, clinical responses remain suboptimal in stage IV patients, due to ineffective T-ce...
Clinical Trial
Frontiers in immunology. 2025 Aug 21:16:1538032. DOI:10.3389/fimmu.2025.1538032 2025
A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers [0.03%]
一项全基因组关联研究确定了与健康医护人员对SARS-CoV-2 mRNA-1273疫苗反应相关的新的遗传位点
Antonio José Cabrera-Serrano,Lucía Ruiz-Durán,Juan Francisco Gutiérrez-Bautista et al.
Antonio José Cabrera-Serrano et al.
Introduction: The COVID-19 pandemic had significant global public health consequences, affecting over 200 countries and regions by 2020. The development and efficacy of specific vaccines, such as the mRNA-1273 (Spikevax®...
Correction: Case Report: CAR-T therapy for primary cerebellar ALK-negative anaplastic large cell lymphoma [0.03%]
纠正：案例报告：针对原发性小脑ALK阴性间变大细胞淋巴瘤的CAR-T治疗
Zhongqing Zou,Sihan Lai,Hai Yi et al.
Zhongqing Zou et al.
[This corrects the article DOI: 10.3389/fimmu.2025.1570214.]. Keywords: ALCL; ALK; CAR-T; CD30; CD7; T-cell ...
Published Erratum
Frontiers in immunology. 2025 Aug 22:16:1674954. DOI:10.3389/fimmu.2025.1674954 2025
Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD [0.03%]
整合scRNA-seq和转录组分析首次揭示单核/巨噬细胞激活驱动EV-A71诱导的手足口病严重免疫紊乱和神经损伤
Muqi Wang,Meng Zhang,Huiling Deng et al.
Muqi Wang et al.
Objective: Enterovirus 71 (EV-A71) is a major pathogen of severe hand, foot and mouth disease (HFMD) in children, but the mechanism by which it develops into severe HFMD remains unclear, especially the role of macrophage-...