The role and prognostic value of PANoptosis-related genes in skin cutaneous melanoma [0.03%]
皮肤黑色素瘤中PAN凋亡相关基因的作用及预后价值分析
Huijing Feng,Linzi Jia,Yanan Ma et al.
Huijing Feng et al.
Introduction: Skin cutaneous melanoma (SKCM), a malignant tumor, has PANoptosis implicated in its progression and metastasis. However, the exact mechanisms remain unclear. This study aims to develop a prognostic model for...
Romy Kronstein-Wiedemann,Madeleine Teichert,Elisa Michel et al.
Romy Kronstein-Wiedemann et al.
Introduction: 1-5% of all patients with COVID-19, a disease caused by infection with Severe Acute Respiratory Syndrome Virus 2 (SARS-Cov-2), even those with mild COVID-19 symptoms, continue to have symptoms after initial ...
Wharton's jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway [0.03%]
玻璃状质衍生的间充质干细胞通过COX2-PGE2通路促进M2型巨噬细胞极化从而缓解高原性心肌损伤
Wenhong Zhang,Li Zhao,Jing Cui et al.
Wenhong Zhang et al.
Background: Chronic high-altitude hypobaric hypoxia leads to high-altitude heart disease and heart failure. Recent research has indicated that WJMSCs (Wharton's jelly-derived mesenchymal stem cells, WJMSCs) can alleviate ...
Performance of eight serum cytokine/chemokine biomarkers in discriminating between active and latent tuberculosis infection in Ghana [0.03%]
区分加纳活动性结核病和潜伏性结核感染的八种血清细胞因子/趋化因子生物标志物的性能评估
Gloria Ivy Mensah,Jones Amo Amponsah,Nana Boakye Alahaman et al.
Gloria Ivy Mensah et al.
Introduction: The existing Interferon γ release assay (IGRA) tests for TB infection, lacks utility in discriminating between active TB (ATB) and latent TB infection (LTBI). This study evaluated the potential of eight ser...
Comparative efficacy and safety of rhTPO, romiplostim, and eltrombopag in the treatment of pediatric primary immune thrombocytopenia: a systematic review and network meta-analysis [0.03%]
rhTPO、罗米普利斯特和艾曲波帕治疗儿童原发性免疫性血小板减少症的疗效和安全性比较：系统评价和网络Meta分析
Xiaofang Zhang,Yuan Zhao,Minghang Yang et al.
Xiaofang Zhang et al.
Background: Pediatric primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia and an increased risk of bleeding. Conventional therapies, while effective in some cases, ar...
Exploring the shared molecular mechanisms of primary hypertension and IgA vasculitis through a case report and combining bioinformatics analysis [0.03%]
通过病例报告并通过结合生物信息学分析探讨原发性高血压和IgA血管炎的共同分子机制
Qijiao Wei,Jiayan Feng,Yifei Mu et al.
Qijiao Wei et al.
Background: Primary hypertension (PHTN) and IgA vasculitis (IgAV) are two prevalent medical conditions that affect the kidneys. Despite their distinct pathophysiological mechanisms, clinical manifestations, and treatment ...
Phase I/II clinical trial on the safety and preliminary efficacy of donor-derived anti-leukemia cytotoxic T lymphocytes for the prevention of leukemia relapse in children given haploidentical hematopoietic stem cell transplantation: study rational and design [0.03%]
单倍型相合造血干细胞移植后供者来源抗白血病CTLs预防儿童复发的I/II期临床研究：研究理据和设计
Daniela Montagna,Patrizia Comoli,Matteo Tanzi et al.
Daniela Montagna et al.
Leuk-CTL-001 (EudraCT n. 2019-003362-41) is a Phase I/II clinical trial on the safety and preliminary efficacy of donor-derived anti-leukemia cytotoxic T lymphocytes (CTLs) for the prevention of leukemia relapse in children given haploident...
Clinical Trial
Frontiers in immunology. 2025 Jun 6:16:1601961. DOI:10.3389/fimmu.2025.1601961 2025
Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications [0.03%]
应用恒河猴包膜假型慢病毒载体转导γδT细胞表达嵌合抗原受体的转化和临床研究
Lorraine Pinot,Aylin Saßor,Nina Möker et al.
Lorraine Pinot et al.
γδ T cells represent a promising cell platform for adoptive cell therapy. Their natural anti-tumor reactivity and HLA-independent target cell recognition make them an attractive platform for allogeneic adoptive immunotherapy clinical inte...
Editorial: Community series in autoimmune diabetes: molecular mechanisms and neoantigens, volume II [0.03%]
编者按：自身免疫糖尿病社区系列：分子机制和新抗原，第二卷
Arnaud Zaldumbide,Sally C Kent
Arnaud Zaldumbide
The N-6 methyladenosine dynamics in STEMI and the effect of IL-6 inhibition - a hypothesis generating sub-study of the ASSAIL-MI trial [0.03%]
梗死急性期N6甲基腺苷动态变化及其与白介素-6抑制的相关性——ASSAIL-MI试验的假说生成性亚研究
Tuva B Dahl,Ana Quiles-Jiménez,Kaspar Broch et al.
Tuva B Dahl et al.
Background: Epitranscriptomics, with m6A as the most prevalent in mammals, is a novel treatment target for inflammatory diseases, including cardiovascular diseases. However, little is known about m6A RNA-regulation during...