Efficacy and safety of first-line treatments for recurrent or metastatic nasopharyngeal carcinoma: a systematic review and network meta-analysis [0.03%]
复发或转移性鼻咽癌一线治疗疗效和安全性的系统评价和网络meta分析
Tongze Cai,Caiyue Lin,Qiongqian Li et al.
Tongze Cai et al.
Background: To compare the efficacy and safety of first-line treatments for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). Methods: ...
Itaconate and obesity-related hormones promote tumor progression - new insights on metabolic dysfunction in early-onset colon cancer [0.03%]
ITA和肥胖相关激素促进肿瘤进展——早发性结肠癌代谢障碍的新见解
Katharina M Scheurlen,Jacob Hallion,Dylan L Snook et al.
Katharina M Scheurlen et al.
Introduction: Obesity is a strong risk factor for early-onset colon cancer (EOCC) and is associated with chronic inflammation largely mediated by macrophages. The macrophage-specific metabolite itaconate promotes growth i...
TMEM115: a promising marker for glioma immunotherapy and prognosis [0.03%]
TMEM115：胶质瘤免疫治疗与预后的潜在生物标志物
Hang Yin,Feng Wang,Haiyan Xu et al.
Hang Yin et al.
Background: Glioma is a common malignant primary brain tumor characterized by a highly immunosuppressive tumor microenvironment and unfavorable prognosis. Transmembrane protein 115 (TMEM115) is a protein-coding gene. It m...
Tryptophan pathway profiling in multiple sclerosis patients treated with ocrelizumab [0.03%]
奥法木单抗治疗的多发性硬化症患者色氨酸代谢途径检测
Carolina Ricci,Matteo Pivetta,Eleonora Martinis et al.
Carolina Ricci et al.
Introduction: L-Tryptophan (Trp) metabolism is impaired across various chronic inflammatory pathologies, including Multiple Sclerosis (MS). Trp processing relies on three metabolic routes, namely Kynurenine, Serotonin and...
Povetacicept (ALPN-303; TACI vTD-Fc), an enhanced, potent dual inhibitor of BAFF and APRIL, ameliorates experimental autoimmune myasthenia gravis in C57BL/6N mice [0.03%]
一种增强型、高效的B细胞激活因子（BAFF）和增殖诱导配体（APRIL）双靶点抑制剂Povetacicept(ALPN-303；TACI vTD-Fc)改善C57BL/6N小鼠自身免疫性重症肌无力的实验研究
Elena Rinaldi,Elisa Puleo,Alessandra Consonni et al.
Elena Rinaldi et al.
Background and objectives: Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disease targeting the acetylcholine receptor (AChR) and other proteins of the neuromuscular junction postsynaptic membran...
Integrated analysis of myeloperoxidase in gastric health and cancer: associations with pepsinogen levels, immune regulation, and prognosis in a large healthy population-based and TCGA cohorts [0.03%]
基于大规模健康人群和TCGA队列的胃健康和癌症中髓过氧化物酶的综合分析及其与胃蛋白酶原水平、免疫调节和预后的关系
Junteng Zhou,Qihang Kong,Xiaojing Liu et al.
Junteng Zhou et al.
Background: Myeloperoxidase (MPO) is a key enzyme involved in immune responses and oxidative stress, yet its roles in gastric physiology and gastric cancer remain incompletely understood. This study comprises two independ...
Statin use during intensive care unit stay is associated with improved clinical outcomes in critically ill patients with sepsis: a cohort study [0.03%]
ICU住院期间使用他汀与重症患者脓毒症临床结局改善有关：队列研究
Caifeng Li,Ke Zhao,Qian Ren et al.
Caifeng Li et al.
Background: Despite early goal-directed therapy, sepsis mortality remains high. Statins exhibit pleiotropic effects, including anti-inflammatory and antimicrobial properties, which may be beneficial during sepsis. ...
Xianfeng Zhou,Han Mo,Hui Li et al.
Xianfeng Zhou et al.
Background: Hand, foot, and mouth disease (HFMD) is an acute infectious disease caused by human enteroviruses (EVs). EVs are most prevalent in children under five years of age and have the potential to result in herpangin...
Single-cell and spatial transcriptomics reveal a stress-induced EMT-like epithelial subset driving immune activation in silica-injured lung [0.03%]
单细胞和空间转录组揭示了硅沉着病致肺损伤相关应激诱导的类似上皮-间质转化亚群及其促免疫活化作用
Tao Wang,Jianfeng Hao,Bing Li et al.
Tao Wang et al.
The mechanism that lung epithelial cells regulate immune responses during chronic injury still remains unclear. Here, we combined single-cell RNA sequencing with spatial transcriptomics to track epithelial dynamics in silica (SiO2)-exposed ...
Elevated Siglec-7 expression correlates with adverse clinicopathological, immunological, and therapeutic response signatures in breast cancer patients [0.03%]
Siglec-7高表达与乳腺癌患者的不良临床病理、免疫和治疗反应特征相关
Hamza Benthami,Basma Zohair,Ibtissam Rezouki et al.
Hamza Benthami et al.
Introduction: Breast cancer is a highly heterogeneous malignancy, characterized by an intricate, hypersialylated tumor microenvironment that actively inhibits immune functions. Although immune checkpoint inhibitors have m...