Comprehensive analysis based on the ubiquitination- and deubiquitylation-related genes reveals the function of NEURL3 in esophageal squamous cell carcinoma [0.03%]
基于泛素化和去泛素化相关基因的全面分析揭示NEURL3在食管鳞癌中的功能
Yi-Wei Lin,Hui-Er Li,Chao-Qun Hong et al.
Yi-Wei Lin et al.
Background: As a highly invasive gastrointestinal malignancy, esophageal squamous cell carcinoma (ESCC) carries with its high morbidity and mortality. Accumulating evidence indicates that abnormal activation of ubiquitina...
Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease [0.03%]
代谢功能紊乱相关脂肪性肝病早晚期患者外周血Th-17细胞比例升高及Treg细胞比例降低
Elżbieta Supruniuk,Kamil Grubczak,Anna Parfieniuk-Kowerda et al.
Elżbieta Supruniuk et al.
Background: Dysregulation of immune responses may influence the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH). Our recent data s...
Kaempferol as a multifaceted immunomodulator: implications for inflammation, autoimmunity, and cancer [0.03%]
kaempferol作为多面手免疫调节剂：对炎症、自身免疫和癌症的意义
Han Dong,Ge Song,Zhe Wang et al.
Han Dong et al.
Kaempferol (KMF) is a dietary flavonoid exhibiting profound immunomodulatory effects across multiple immune cell populations. This review synthesizes current insights into how KMF regulates diverse immune cell populations and its therapeuti...
Attenuation of IFITM proteins' antiviral activity through sequestration into intraluminal vesicles of late endosomes [0.03%]
干扰素诱导的跨膜蛋白抗病毒活性通过晚期内体腔内囊泡隔离而衰减
David Prikryl,You Zhang,Smita Verma et al.
David Prikryl et al.
Introduction: Interferon-induced transmembrane proteins (IFITMs) inhibit the entry of diverse enveloped viruses. The spectrum of antiviral activity of IFITMs is largely determined by their subcellular localization. IFITM1...
The impact of immunotherapy on the prognosis of small cell carcinoma of the esophagus: a propensity score-matched analysis of a retrospective study [0.03%]
免疫治疗对食管小细胞癌预后影响的倾向分值匹配分析回顾性研究
Bing Wang,Tianxing Liu,Zhe Yang et al.
Bing Wang et al.
Objective: Small cell carcinoma of the esophagus (SCCE) is a rare neuroendocrine malignancy with no standardized treatment regimen. This study aims to evaluate the impact of immunotherapy on the prognostic survival outcom...
Matilde Otero-Losada,Rodolfo Kölliker-Frers,Radjesh Bisoendial et al.
Matilde Otero-Losada et al.
Case Report: Abscopal effect and long-term survival in a PD-L1 negative NSCLC patient treated with radiotherapy and immuno-chemotherapy [0.03%]
个例报告：一例经放疗和免疫化疗治疗的PD-L1阴性的NSCLC患者的远隔效应及长期生存
Qiang Wen,Weiqi Wang,Ke Zhang et al.
Qiang Wen et al.
We present a case of a 68-year-old male with advanced non-small cell lung cancer (NSCLC), PD-L1 negative and driver gene negative, who exhibited a significant abscopal effect following radiotherapy combined with systemic immunotherapy (sint...
Case Report: Remission of a patient with complex combination of autoimmune diseases by anti-CD19 CAR-T cell therapy [0.03%]
案例报告：抗CD19嵌合抗原受体T细胞治疗改善自身免疫性疾病患者的病情
Xudong Liu,Wenxiang Zhu,Nan Su et al.
Xudong Liu et al.
CAR-T cell therapy has been proven effective in various autoimmune diseases, with most studies utilizing lentiviral-transduced CAR-T cells. In recent years, retroviral vector-transduced CAR-T cells-characterized by a high positivity rate, s...
Identification of galectin-9 and its antibacterial function in Yellow River carp (Cyprinus carpio haematopterus) [0.03%]
黄河鲤鱼半乳糖凝集素-9的鉴定及其抗菌功能研究
Li Wang,Yuanyuan Hu,Xudong Li et al.
Li Wang et al.
Introduction: Galectin-9 is a β-galactoside-binding lectin that functions as a critical pattern recognition receptor (PRR) in the host immune system, initiating immune defense responses by recognizing and binding to path...
Death-associated protein kinase 1: a double-edged sword in health and disease [0.03%]
与死亡相关的蛋白激酶1：健康与疾病中的双刃剑
Xiuli Zhang,Yehuda G Assaraf,Yao Lin
Xiuli Zhang
Death-associated protein kinase 1 (DAPK1) is a Ca2+/calmodulin-regulated serine/threonine kinase that orchestrates a wide array of cellular activities. It is intricately regulated through multiple mechanisms, including intramolecular signal...