Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis [0.03%]
乌帕替尼治疗自身免疫介导的炎症性疾病的有效性和安全性：系统评价和meta分析
Rui Chai,Xiaomin Li,Wei Shen et al.
Rui Chai et al.
Objective: There is a growing array of options for the treatment of immune-mediated inflammatory diseases (IMIDs). To explore upadacitinib's efficacy and safety in autoimmune disease treatment, we conducted this study. ...
Toripalimab plus chemotherapy versus chemotherapy as first-line therapy for extensive-stage small cell lung cancer: a cost-effectiveness analysis [0.03%]
度伐利尤单抗联合化疗和单纯化疗作为广泛期小细胞肺癌一线治疗的成本效益分析
Longfeng Zhang,Hongcai Chen,Huide Zhu et al.
Longfeng Zhang et al.
Objective: The aim of this study was to evaluate the cost-effectiveness of toripalimab plus chemotherapy compared to chemotherapy alone as first-line therapy for extensive-stage small cell lung cancer(ES-SCLC) from the Ch...
Comparative Study
Frontiers in immunology. 2025 Jul 1:16:1591517. DOI:10.3389/fimmu.2025.1591517 2025
Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin [0.03%]
特异性クラゲンcirculating CLA+记忆T细胞可区分atopic dermatitis皮肤中的IL-22反应
Irene García-Jiménez,Lídia Sans-de San Nicolàs,Sandra Díez-Ribas et al.
Irene García-Jiménez et al.
Background: Current understanding of IL-22 in atopic dermatitis (AD) mostly relies on animal models, intracellular staining of polyclonally activated peripheral lymphocytes, and biological therapies. ...
CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects [0.03%]
恶性黑色素瘤脑转移的CTLA-4和PD-1联合阻断治疗：机制、挑战与前景
Jia-Wen Wang,Ying-Fa Feng,Jia-Hui Liu
Jia-Wen Wang
Malignant melanoma brain metastases (MBM) represent one of the deadliest complications of melanoma, with an incidence rate of 7.3%. Among patients with acral and mucosal melanoma, the cumulative 5-year incidence can reach 19.5%, accompanied...
T-cell repertoire correlates with cytokine imbalance in multiple sclerosis patients [0.03%]
多发性硬化患者T细胞受体谱系与细胞因子失衡相关性研究
Lisa Weidner,Rodolphe Poupardin,Tobias Zrzavy et al.
Lisa Weidner et al.
Indroduction: Multiple sclerosis (MS) is mediated by innate and adaptive immune response deviation involving immune cells and cytokines. Here, we investigated whether combined cytokine profiling and T-cell receptor (TCR) ...
Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond MYD88 L265P [0.03%]
免疫球蛋白M型单克隆丙种球蛋白病预后风险组的基因组和免疫特征分析发现MYD88 L265P以外的新生物标志物
David F Moreno,Ferran Nadeu,Fara Brasó-Maristany et al.
David F Moreno et al.
Background: MYD88 L265P is an early mutation in IgM monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic Waldenström macroglobulinemia (WM). Given the high prevalence of the MYD88 mutation observed ...
VISTA functions as a protective immune checkpoint in indirect acute respiratory distress syndrome by modulating systemic and compartmentalized inflammation [0.03%]
VISTA通过调节全身性和隔室炎症在间接性急性呼吸窘迫综合征中发挥保护性的免疫检查点作用
Baoji Hu,Chun-Shiang Chung,Chyna Gray et al.
Baoji Hu et al.
Background: Indirect acute respiratory distress syndrome (iARDS) is a life-threatening inflammatory lung injury often triggered by extrapulmonary insults. Although immune checkpoints are critical regulators of inflammatio...
STING regulates NETs formation by activating GSDMD in influenza viral pneumonia [0.03%]
STING通过激活GSDMD调节流感病毒性肺炎中NETs的形成
Rongrong Huang,Ranran Chen,Lijuan Xing et al.
Rongrong Huang et al.
Background: Viral pneumonia is the most common and lethal pandemic disease, but there are no broad-spectrum antiviral drugs with high genetic barriers to resistance. To elucidate the mechanisms of viral pneumonia progress...
Low nanomolar affinity to major grass pollen allergen Phl p 5 as achieved in an unmutated human antibody-lineage ancestor [0.03%]
低纳摩尔亲和力与主要草花粉过敏原Phl p 5的结合如在人类抗体家系未突变的祖先成员中实现的一样
Mattias Essén,Eric Franciskovic,Céleste Sele et al.
Mattias Essén et al.
Background: Group 5 allergens, such as Phl p 5 of timothy grass, are major contributors to grass pollen allergy. Antibody 212597 specific for this allergen was recently isolated by single cell sequencing of bone marrow B ...
Evaluation of a novel chemiluminescent immunoassay for autoantibody detection in pemphigus and bullous pemphigoid [0.03%]
评估新型化学发光免疫测定法在自身抗体检测中的应用价值——以疱病和大疱性天疱疮为例
Na Zhang,Ming Wang,Lili Hou et al.
Na Zhang et al.
Background: A novel fully automated chemiluminescent immunoassay (CLIA) has been developed to quantify autoantibodies specific for desmogleins (Dsg1, Dsg3), BP180, and BP230, key target antigens in pemphigus and bullous p...