CACUL1 promotes hepatocellular carcinoma progression through enhanced tumor cell proliferation and macrophage-mediated immune suppression [0.03%]
CACUL1通过增强肿瘤细胞增殖和巨噬细胞介导的免疫抑制促进肝癌进展
Xing Wang,Yuhan Tan,Ju Wang et al.
Xing Wang et al.
Background: Although cullin-family E3 ubiquitin ligases regulate diverse oncogenic pathways, the role of CACUL1 in hepatocellular carcinoma (HCC) remains poorly characterized. ...
A transfer learning-based multimodal model for early prediction of 90-day respiratory failure in dermatomyositis-associated interstitial lung disease [0.03%]
基于迁移学习的多模态模型在皮肌炎相关间质性肺病患者90天内呼吸衰竭早期预测中的应用研究
Lihui Guo,Yaning Yao,Qirui Wu et al.
Lihui Guo et al.
Background: Dermatomyositis-associated interstitial lung disease (DM-ILD) is a life-threatening condition that often leads to respiratory failure, poor prognosis, and high mortality, especially in patients positive for an...
An updated review on the role of extracellular vesicles in immune system modulation in breast cancer with special emphasis on immune checkpoint regulators [0.03%]
关于乳腺癌中外泌体调节免疫系统作用的最新综述，特别侧重于免疫检查点调节因子的作用
Jayenth Jayachandran,Surajit Pathak,Zulya Maizetova et al.
Jayenth Jayachandran et al.
Breast cancer progression and resistance to therapy are strongly influenced by immune evasion within the tumor microenvironment. Immune checkpoint signaling is a major mechanism by which cancer cells evade immune surveillance, thereby promo...
Divergent immunometabolic reprogramming in psoriasis and atopic dermatitis: a tale of two inflammatory skin diseases [0.03%]
银屑病和特应性皮炎的免疫代谢重编程差异：两种炎症性皮肤病的故事
Nan Chen,Yehong Yue,Liang Zhou
Nan Chen
Psoriasis (PSO) and atopic dermatitis (AD) are the two most common chronic inflammatory skin diseases in clinical practice. For a long time, they have been classified in pathological immunology under the opposing model of "Th17/IL-17 vs. Th...
KA101 outperforms other clinical adjuvants in inducing balanced Th1/Th2 immunity and robust B cell responses to varicella-zoster virus glycoprotein E [0.03%]
KA101在诱导平衡的Th1/Th2免疫和针对水痘带状疱疹病毒糖蛋白E的 robust B细胞反应方面优于其他临床免疫佐剂
Yaru Quan,Su Zhang,Wenwen Wang et al.
Yaru Quan et al.
Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster, which can further progress to persistent postherpetic neuralgia in a subset of patients. Rational adjuvant selection is critical for the development of recombinant VZ...
Zolbetuximab in the treatment of advanced gastric and gastroesophageal junction cancer: a systematic review [0.03%]
佐鲁倍昔单抗治疗晚期胃及胃食管交界处癌症的疗效和安全性系统评价及 meta 分析
Natalia Picheta,Julia Piekarz,Jakub Pobideł et al.
Natalia Picheta et al.
Introduction: Advanced gastric and gastroesophageal junction (G/GEJ) adenocarcinomas are characterized by an aggressive course and a very poor prognosis. Due to the limited benefit of immunotherapy in patients with HER2-n...
Adverse event reporting patterns of rituximab and obinutuzumab in B-cell non-Hodgkin lymphoma: a FAERS pharmacovigilance study [0.03%]
利妥昔单抗和奥滨尤特木单抗在B细胞非霍奇金淋巴瘤不良事件报告模式：来自FAERS的药物警戒研究
Weihao Ma,Hongbo Fu,Yanqiong Zhou et al.
Weihao Ma et al.
Background: Rituximab and obinutuzumab share the CD20 target but are used across distinct B-cell non-Hodgkin lymphoma (B-NHL) subtypes, treatment backbones, and clinical eras. Their real-world adverse event (AE) reporting...
99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake phenotypes and metabolic-stromal heterogeneity in advanced differentiated thyroid carcinoma: a prospective single-center imaging-radiomics study [0.03%]
99mTc-FAPI-YQ3 SPECT/CT在分化型甲状腺癌晚期FAPI摄取表型和代谢-基质异质性特征中的作用：一项前瞻性单中心影像组学研究
Peng Zhou,Pengjun Zhang,Yang Luo et al.
Peng Zhou et al.
Objective: Advanced and metastatic differentiated thyroid carcinoma (DTC), particularly radioactive iodine (RAI)-refractory disease, is characterized by spatially heterogeneous tumor biology and limited therapeutic option...
Observational Study
Frontiers in immunology. 2026 Jul 16:17:1888899. DOI:10.3389/fimmu.2026.1888899 2026
High-resolution mapping of chromatin conformation in HBeAg-treated macrophage provides insights into pathogenesis of HBV-related liver diseases [0.03%]
HBV相关肝病发病机制的HBeAg诱导的小胶质细胞染色质构象高分辨率图谱解析
Tiantian Liu,Xiaoyu Xie,Shujun Ma et al.
Tiantian Liu et al.
Background: Hepatitis B virus (HBV) e antigen (HBeAg) plays a critical role in inducing macrophage activation and subsequent immune tolerance, which facilitates viral immune escape. However, the underlying spatial 3D geno...
Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models [0.03%]
卒中相关性肺炎的免疫调节治疗：动物模型中的机制研究和新兴治疗策略的系统评价
Xiangyun Chen,Yihe Xu,Yonghong Gao et al.
Xiangyun Chen et al.
Backgrounds and aims: Stroke-associated pneumonia (SAP) is a major infectious complication that increases mortality after stroke. Stroke-induced immunosuppression has been proposed as a key driver of SAP, supporting the r...