Javier Zumárraga,Daniel López,Javier Sotillo et al.
Javier Zumárraga et al.
Reverse vaccinology (RV) was originally conceived to leverage genomic information for antigen selection and promised a paradigm change in vaccine design. After a steady increment since 2000 and surge in 2021, RV-related publications have re...
Impact of rice wine-steamed Cistanche deserticola polysaccharides on intestinal flora and immunological modulation in immunosuppressive mice induced by cyclophosphamide [0.03%]
米酒蒸锁阳多糖对环磷酰胺所致免疫抑制小鼠肠道菌群及免疫调节的影响
Jing Lian,Yuexin Zhu,Qiushi Hu et al.
Jing Lian et al.
Introduction: Cistanche deserticola, a valued medicinal and food homologous material in traditional Chinese medicine, is renowned for enhancing immunity and protecting the mucosal barrier, with polysaccharides considered ...
Advances and prospects of mucosal vaccination in the prevention and control of avian influenza [0.03%]
禽流感黏膜免疫疫苗研究进展与前景分析
Xianfeng Hui,Xiaowei Tian,Shihuan Ding et al.
Xianfeng Hui et al.
Avian influenza virus (AIV) poses a persistent threat to global poultry production and public health. Long-term immunization programs have established a foundational immune barrier, significantly mitigating the risk of highly pathogenic avi...
Unique chicken B cell development: species-specific mechanisms and contradictory requirements of B cell receptor for post-hatched B cell development [0.03%]
独特的鸡B细胞发育：物种特异性的机制及B细胞受体对孵化后B细胞发育的矛盾要求
Seung Je Woo,Thirubasyini Songodan,Jae Yong Han
Seung Je Woo
Chicken B cell development represents a remarkable evolutionary divergence from mammalian paradigms, featuring unique three-stage ontogeny centered on the bursa of Fabricius, an avian-specific primary B cell lymphoid organ. Unlike mammals w...
Microglia heterogeneity and therapeutic strategies in Parkinson's disease [0.03%]
帕金森病的小胶质细胞异质性与治疗策略
Jing Tian,Xuehui Liu,Zhuoqun Wang et al.
Jing Tian et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the abnormal aggregation of α-synuclein (α-syn). PD exhibits fea...
Efficacy and safety of Nefecon in IgA nephropathy: real world clinical practice [0.03%]
Nefecon在IgA肾病患者中的有效性和安全性：真实世界临床实践
Zihan Zhai,Zhibin Huang,Liuwei Wang et al.
Zihan Zhai et al.
Introduction: The targeted-release budesonide formulation (Nefecon) addresses IgA nephropathy (IgAN) by inhibiting mucosal immune dysregulation in gut-associated lymphoid tissue (GALT), leading to reduced production of ga...
A multimodal biological margin risk index predicts recurrence after neoadjuvant immunochemotherapy in head and neck squamous cell carcinoma [0.03%]
术前免疫化疗新辅助治疗头颈部鳞癌的多模态生物边缘风险指数可以预测复发事件
Ning Xu,Defeng Chen,Junui Yuan et al.
Ning Xu et al.
Background: Conventional classification of surgical margins is inadequate for head and neck squamous cell carcinoma (HNSCC) treated with neoadjuvant immunochemotherapy (NICT), as it fails to capture the complex biological...
Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway [0.03%]
钙信号相关基因在膀胱癌中的预后意义及ATP2B4通过VDAC1/MCU通路调节线粒体钙离子水平的作用研究
Lulu Zhang,Yu Gong,Jiajun Chen et al.
Lulu Zhang et al.
Background: Calcium signaling, as a ubiquitous intracellular signal in eukaryotes, has been impacted in multiple biological processes encompassing tumorigenesis. Nevertheless, the integrated investigations on the function...
Tocilizumab combined with short-term high-dose glucocorticoids for rapid disease activity control and glucocorticoid reduction in adult-onset Still's disease: a single-center retrospective study [0.03%]
托珠单抗联合短期大剂量糖皮质激素治疗成人Still病以迅速控制疾病活动度和减量糖皮质激素：一项单中心回顾性研究
Shi-Lei Zhong,Yan-Ping Lei,Li-Xuan Zhou et al.
Shi-Lei Zhong et al.
Objectives: This study aimed to evaluate the effectiveness of tocilizumab (TCZ) combined with short-term high-dose glucocorticoids in rapidly controlling disease activity and reducing glucocorticoid use in patients with a...
In silico design of a multiepitope subunit vaccine targeting Salmonella enterica serovar Infantis: an immunoinformatics and reverse vaccinology approach [0.03%]
针对沙门氏菌肠炎变种的多抗原亚单位疫苗的计算机设计：免疫信息学和反向疫苗学方法
Dhiraj Chundru,Mostafa Ghanem
Dhiraj Chundru
Salmonella enterica serovar Infantis is an emerging zoonotic pathogen increasingly linked to poultry and multidrug-resistant human infections. Existing vaccines lack serovar-specific efficacy, underscoring the need for targeted immunization...