Mechanism of blueberry anthocyanins in ameliorating radiation-induced intestinal injury through gut microbiota modulation [0.03%]
通过调节肠道菌群减轻辐射引起的肠损伤的蓝莓花青素的作用机制
Aijing Yang,Beibei Zhang,Jiayuan Ju et al.
Aijing Yang et al.
Background: Radiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionizing radiation, such as that employed in radiation therapy for malig...
Macrophages dynamically integrate neuro-immune-microbial network signals: their role in gastrointestinal motility disorders and targeting potential [0.03%]
巨噬细胞动态整合神经-免疫-微生物网络信号：其在胃肠运动障碍中的作用及靶向治疗潜力
Weiqing Yang,Sunan Yong,Qiang Zhang et al.
Weiqing Yang et al.
Gastrointestinal motility disorders are pathologically characterized by dysregulation of the tripartite network comprising the intestinal immune system, the enteric nervous system, and the gut microbiota. Targeted medicines that target impo...
Huihan Wang,Jinsong Yuan,Hong Wang
Huihan Wang
Human Immunodeficiency Virus (HIV), including HIV-1 and HIV-2, is a retrovirus that causes Acquired Immunodeficiency Syndrome (AIDS). HIV primarily targets the human immune system, especially CD4+ T lymphocytes, leading to progressive immun...
Quercetin attenuates skin inflammation and fibrosis in systemic sclerosis by targeting the RELA/c-Jun axis to suppress th17 cell responses [0.03%]
檞皮素通过靶向RELA/c-Jun轴抑制Th17细胞反应从而减轻系统性硬化症的皮肤炎症和纤维化
Xiangzhen Kong,Hiochon Leong,Min Du et al.
Xiangzhen Kong et al.
Background: Aberrant Th17 cell activation and interleukin-17 (IL-17) production drive skin inflammation and progressive fibrosis in systemic sclerosis (SSc). Identifying small molecules that can precisely modulate these p...
Comprehensive antiphospholipid antibody profiling and unsupervised immune phenotyping in fetal growth restriction [0.03%]
抗磷脂抗体全面检测及胎儿生长受限的无监督免疫表型分析
Siyin Li,Xiaofang Shu,Juan Shi et al.
Siyin Li et al.
Background: Non-criteria antiphospholipid antibodies (aPLs) may be associated with adverse obstetric outcomes in patients who do not meet conventional antiphospholipid syndrome (APS) classification criteria. Their clinica...
Effect of histology on the efficacy of first-line immune checkpoint inhibitors in advanced non-small cell lung cancer: a systematic review and network meta-analysis [0.03%]
组织学对晚期非小细胞肺癌一线免疫检查点抑制剂疗效的影响：系统评价和网络Meta分析
Sihan Li,Tianyu He,Jun Chen et al.
Sihan Li et al.
Background: First-line immune checkpoint inhibitors (ICIs) have become the standard of care for advanced non-small cell lung cancer (NSCLC). However, whether tumor histology influences the efficacy of ICIs remains unclear...
Clinical exploration of first-line therapy in metastatic lung adenocarcinoma patients with negative or low PD-L1 expression: a retrospective cohort study [0.03%]
一线治疗驱动基因阴性转移性肺腺癌患者负或低PD-L1表达临床探索性研究：回顾性队列研究
Kun Xu,Ruoxue Cai,Zijian Sun et al.
Kun Xu et al.
Background: Either Programmed cell death protein 1 (PD-1)/Programmed cell death-Ligand protein 1 (PD-L1) inhibitors plus chemotherapy or anti-angiogenic agents plus chemotherapy has become first-line therapy in negative o...
Lymphocyte subsets in untreated thalassemia patients: differences by genotype and age [0.03%]
未经治疗的β-地中海贫血患者中淋巴细胞亚群的差异及其与基因型和年龄的关系
Renbin Zhao,Xiangmei Yao,Shuai Feng et al.
Renbin Zhao et al.
Background: The Lymphocyte subsets in treatment-naïve patients and their variations among different genetic subtypes and age groups remain poorly characterized. ...
Glycolytic reprogramming in ovarian cancer: mechanisms, immune crosstalk, and therapeutic implications [0.03%]
卵巢癌中的糖酵解重组：机制、免疫互作及治疗意义
Jiao Fu,Yi Dai,Qiaoling Wang et al.
Jiao Fu et al.
Ovarian cancer is characterized by extensive peritoneal dissemination, frequent recurrence, and chemoresistance. Glycolytic reprogramming has emerged as a central metabolic adaptation in ovarian cancer, but its significance extends beyond i...
Cell-autonomous co-stimulatory function of membrane-bound CD100 promotes activation and differentiation of HBcAg-specific CD8+ T cells [0.03%]
膜结合CD100的细胞自主共刺激功能促进HBcAg特异性CD8+t细胞的活化及分化
Mengxiao Zhao,Liwei Chen,Yuhang Chen et al.
Mengxiao Zhao et al.
Background: CD100/SEMA4D functions as a critical co-stimulatory molecule in T cell responses, existing in both membrane-bound (mCD100) and soluble (sCD100) forms. Previous studies have shown that CD100 enhances CD8+ T cel...