Nutritional status, immunonutrition, and gut microbiome: a coming of age for immunotherapy? [0.03%]
营养状况、免疫营养和肠道微生物群：免疫疗法即将成熟？
Elisa Mattavelli,Francesco Agustoni,Alice Tartara et al.
Elisa Mattavelli et al.
In the last decades, immunotherapy has revolutionized cancer treatment. Despite its success, a significant number of patients fail to respond, and the underlying causes of ineffectiveness remain poorly understood. Factors such as nutritiona...
Adult onset cryopyrin-associated periodic syndrome due to germline missense mutation in NLRP3 in a previously healthy middle-aged woman [0.03%]
一名此前健康的中年女性出现由于NLRP3基因的错义突变导致的成人期冷吡啉相关周期综合征病例报告
Sung Ik Cho,Sheehyun Kim,Ju Yeon Kim et al.
Sung Ik Cho et al.
Background: Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by a gain-of-function mutation in the NLRP3 gene, which regulates inflammasome-mediated interleukin-1β (IL-1β) production. ...
Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE [0.03%]
移入NSG-SGM3人源化小鼠可自发产生人类免疫球蛋白包括IgE
Erica V Lin,Rebecca A Krier-Burris,Kristina A Sokol et al.
Erica V Lin et al.
NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34+ hematopoietic stem...
Unraveling epigenetic drivers of immune evasion in gliomas: mechanisms and therapeutic implications [0.03%]
解码胶质瘤免疫逃逸的表观遗传驱动因素：机制及治疗意义
Dan Wu,Dongen Ju,Yujia Zhao et al.
Dan Wu et al.
Gliomas are the most common primary malignant tumors of the central nervous system (CNS), and despite progress in molecular diagnostics and targeted therapies, their prognosis remains poor. In recent years, immunotherapy has emerged as a pr...
Glycan dysregulation as one of major metabolic subtypes is associated with TERC overexpression and poor outcomes in cervical cancer [0.03%]
糖链失调与端粒酶RNA成分高表达及预后不良密切相关——宫颈癌代谢亚型的新型标志物
Yanlei Dong,Xinyuan Zhang,Jingjie Zhao et al.
Yanlei Dong et al.
Background: Metabolic reprogramming is an important hallmark of cervical cancer (CC), and extensive studies have provided important information for translational and clinical oncology. Here we sought to determine metaboli...
Exploring the biological functions and immune regulatory roles of IRAK3, TNFRSF1A, CX3CR1, and JUNB in T2DM combined with MAFLD: integrated bioinformatics and single-cell analysis [0.03%]
探究IRAK3、TNFRSF1A、CX3CR1和JUNB在2型糖尿病合并MAFLD中的生物学功能及免疫调节作用：整合生物信息学与单细胞分析
Qin Wang,Xiaoqi Li,Kaidierdan Wushoulaji et al.
Qin Wang et al.
Objective: Diabetes mellitus combined with nonalcoholic fatty liver disease is a prevalent and intricate metabolic disorder that presents a significant global health challenge, imposing economic and emotional burdens on s...
The role of reactive oxygen species in the transformation from prostatitis to prostate cancer: a review [0.03%]
反应性氧簇在前列腺炎向前列腺癌转化中的作用：综述论文
Kaihua Tang,Zhipeng Jiang,Wen Luo et al.
Kaihua Tang et al.
In the study of prostate diseases, the microenvironment associated with chronic prostatitis is characterized by abnormal activation of immune cells, leading to excessive accumulation of pro-inflammatory factors and an imbalance in the antio...
Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones [0.03%]
常规和非常规抗原结合位点促进慢性淋巴细胞白血病 stereotype 组 4 克隆的发展与功能
Yun Liu,Dzmitry Padhorny,Rosa Catera et al.
Yun Liu et al.
Immunoglobulins (IGs) made by chronic lymphocytic leukemia (CLL) B cells are unique in that they bind themselves (homo-dimerize). This interaction leads to signal transduction with functional consequences that depend on the affinity of homo...
Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome [0.03%]
甘丙糖蛋白组学分析补体因子H及其在肺炎链球菌相关溶血性尿毒综合征中的补体调节功能
Laura M Baas,Kioa L Wijnsma,Fokje Zijlstra et al.
Laura M Baas et al.
Hemolytic uremic syndrome caused by an invasive Streptococcus pneumoniae infection (SP-HUS) is a rare and severe disease that primarily affects children under two years of age. The pathophysiology of SP-HUS remains poorly understood, and tr...
Circular RNA hsa_Circ_0007552 inhibits lung adenocarcinoma proliferation, migration and invasion via the miR-7974/BAP1 axis [0.03%]
circRNA hsa_Circ_0007552通过miR-7974/BAP1轴抑制肺腺癌的增殖、迁移和侵袭
Yanping Lin,Rong Li,Xin Shen et al.
Yanping Lin et al.
Objectives: Circular RNAs (circRNAs) are a class of non-coding RNAs with diverse pathophysiological functions. However, the functional roles and molecular mechanisms of circRNAs in lung adenocarcinoma (LUAD) remain to be ...