The F1F3 recombinant chimera induced higher vaccine efficacy than its independent F1 and F3 components against Leishmania (L.) infantum chagasi mice infection [0.03%]
与单用F1或F3亚单位疫苗相比，F1F3重组嵌合体疫苗对婴儿杜氏利什曼原虫感染小鼠的免疫保护效果更佳
Daniele Crespo Gomes,Maria Paula Fonseca-Ribeiro,Marcus Vinicius Alves-Silva et al.
Daniele Crespo Gomes et al.
Introduction: Visceral leishmaniasis (VL) is a severe human vector-borne CD4-immunosuppressive disease that can be lethal if untreated soon after symptoms arise. No vaccine is available against human VL, and its chemother...
CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs [0.03%]
人和小鼠工程化CXCR5调节性T细胞在二级及三级淋巴器官中的靶向抑制作用
Matteo Doglio,Jyoti Rana,Adriana Stucchi et al.
Matteo Doglio et al.
Introduction: Secondary and tertiary lymphoid structures are a critical target of suppression in many autoimmune disorders, protein replacement therapies, and in transplantation. Although antigen-specific regulatory T cel...
Cimifugin ameliorates ulcerative colitis-related lung injury by modulating the JAK1/STAT1 signaling pathway and macrophage M1 polarization [0.03%]
柴胡皂苷d通过调节Janus激酶1/信号转导和转录激活因子1信号通路和巨噬细胞M1极化缓解溃疡性结肠炎相关肺损伤
Guanyuan Wang,Fan Yang,Guodong Zang et al.
Guanyuan Wang et al.
Introduction: Ulcerative colitis (UC)-related lung injurys is a commonly overlooked extraintestinal manifestation and there are currently no drugs with definitive efficacy available. Cimifugin has been found to inhibit ab...
Chronic ethanol administration exacerbates memory loss by altering N6-methyladenosine-mediated epigenetic signaling [0.03%]
慢性乙醇给药通过改变N6-甲基腺苷介导的表观遗传信号加剧记忆丧失
Yuanhang Liao,Fu Xu,Yuqing Yan et al.
Yuanhang Liao et al.
Background: Chronic alcohol use disorder (AUD) is recognized as one of the most critical risk factors for the progression of Alzheimer's disease (AD). Epigenetic and neuroimmune alterations are closely associated with the...
Rare type A lymphomatoid papulosis initially presenting as a giant ulcer: a case report and literature review [0.03%]
关于肿瘤样乳头状皮病罕见A型的首诊病例报告及文献回顾（一种巨大的溃疡）
Xiangru Chen,Qingling Zhang,Jingtong Zhao et al.
Xiangru Chen et al.
Background: Lymphomatoid papulosis (LyP) is a rare, chronic, recurrent, self-healing, indolent cutaneous lymphoproliferative disorder. Histologically, it resembles malignant lymphoma; however, its clinical manifestations ...
Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer [0.03%]
单细胞RNA和批量RNA测序的整合揭示了胰腺癌恶性导管细胞异质性和预后特征
Haiyang Du,Gao Si,Jiqing Si et al.
Haiyang Du et al.
Introduction: Pancreatic cancer is a highly malignant tumor of the digestive system with a dismal prognosis. Despite advances in diagnosis and treatment, overall survival remains extremely low. Early diagnostic markers an...
Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade [0.03%]
胃癌中的半乳糖凝集素-9和T细胞免疫球蛋白黏蛋白-3：一个独立于抗PD-1阻断的检查点轴，通过耗竭T细胞和调节性T细胞介导的免疫抑制发挥作用
Charlotte N Hill,Gabriela Maita,Camille Cabrolier et al.
Charlotte N Hill et al.
Immune checkpoint inhibitors have significantly advanced the treatment of gastric cancer (GC), yet therapeutic resistance remains common due to the immunosuppressive tumor microenvironment and redundancy among inhibitory checkpoints. Tim-3 ...
Quantitative bead-based multiplex assay for simultaneous determination of IgG concentrations of pertussis toxin, filamentous hemagglutinin, pertactin, diphtheria, tetanus, Haemophilus influenzae b, and hepatitis B in human serum samples [0.03%]
人血清样品中白喉、破伤风、百日咳毒素、纤毛素血凝素、保护性抗原及b型流感嗜血杆菌和乙型肝炎抗体浓度的定量测定的多重珠基质测定法
Vishal Rathod,Sagar Katke,Sumant Patil et al.
Vishal Rathod et al.
Background: Multiplex serological assays provide opportunities for seroprevalence studies and for evaluating antibodies post-vaccination. In this report, we describe the development and validation of a seven-plex bead-bas...
Retinoic acid differently modulates NOD1/NOD2-mediated inflammatory responses in human macrophage subsets [0.03%]
视黄酸通过调节人类单核细胞来源的巨噬细胞亚群中NOD1/NOD2介导的炎症反应
Hala Ahmad,Ahmad Alatshan,Eduárd Bíró et al.
Hala Ahmad et al.
Macrophages are indispensable in homeostasis and innate immune responses in multiple tissues, while their polarization and functional characteristics are determined by the activating stimuli and their tissue microenvironment. The vitamin A ...
Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs [0.03%]
不同佐剂联合注射和粘膜免疫接种可诱导长效的肺部CD4+t细胞反应
Ranmali Kavishna,Thorunn Asta Olafsdottir,Siggeir F Brynjólfsson et al.
Ranmali Kavishna et al.
Introduction: Airway mucosa represents the main entry point for several human pathogens, and as such vaccines against respiratory diseases should ideally elicit protective immune responses in the airways. We have previous...