Niche-driven microbial architecture in mothers and newborns with minimal cohort influence across anatomically distinct sites [0.03%]
独立于队列影响的母体和新生儿各解剖部位小生境驱动的微生物群落结构
Norbert Dera,Natalia Żeber-Lubecka,Joanna Ziemska-Legiecka et al.
Norbert Dera et al.
The microbiota plays a crucial role in the functioning of the human body. Several theories have been proposed regarding the origin of the uterine microbiota, including both ascending pathways from the vagina and translocation from the gastr...
Guanxinjing ameliorates coronary microvascular dysfunction in myocardial ischemia-reperfusion injury by alleviating inflammation and restoring endothelial function [0.03%]
关心径通过抗炎和恢复内皮功能改善心肌缺血再灌注损伤时的冠脉微血管功能障碍
Yaoting Wang,Lan Li,Liang Jin et al.
Yaoting Wang et al.
Background: Coronary microvascular dysfunction (CMD) secondary to myocardial ischemia-reperfusion injury (MIRI) is characterized by profound inflammatory activation and endothelial impairment. Guanxinjing compound (GXJC) ...
Parasite in cancer therapy: molecular mechanisms and translational potential [0.03%]
寄生虫在癌症治疗中的作用：分子机制和转化潜力
Juanyan Liao,Xingyu Hou,Haolin Tang et al.
Juanyan Liao et al.
Parasite-derived molecules have emerged as a promising source of natural bioactive compounds with immunomodulatory and antitumor properties, attracting increasing attention in cancer research. Derived from both protozoan and helminth parasi...
The role of macrophage polarization in organ transplantation: research progress on impact on graft injury, repair, and fibrosis [0.03%]
巨噬细胞极化在器官移植中的作用：对移植物损伤、修复及纤维化的研究进展
Liping Wang,Lijuan Wang,Xu Chen et al.
Liping Wang et al.
Organ transplantation is a life-saving therapy for patients with end-stage organ failure. However, post-transplant graft injury, immune rejection, and chronic fibrosis severely compromise the long-term survival of recipients and graft funct...
Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives [0.03%]
创伤性脓毒症的胃肠轴：从分子机制到转化视角
Xiang-Yu Liu,Tian Liu,Jia-Ke Chai et al.
Xiang-Yu Liu et al.
Post-traumatic sepsis is the leading cause of late mortality in intensive care units. While the concept of "gut-origin sepsis" has evolved over the past three decades, the stomach has largely been overlooked as an active contributor. This r...
Perioperative neurocognitive disorders as a neuroimmune landscape disorder: microglial priming, state heterogeneity, and time-dependent neuroinflammation [0.03%]
围手术期神经认知障碍作为神经免疫景观障碍：小胶质细胞活化、状态异质性和时间依赖性神经炎症
Mengjie Chen,Jiaqi Ning,Jiaxi Liu et al.
Mengjie Chen et al.
Perioperative neurocognitive disorders (PND) are common and highly heterogeneous neurological complications in older and otherwise vulnerable surgical patients, with clinical manifestations ranging from delayed cognitive recovery to persist...
Superior inflammatory response and MASH progression in Apoe -/- mice compared to wild-type mice: a comprehensive time-course analysis [0.03%]
Apoe基因敲除小鼠炎性反应和泡沫细胞形成增强及动脉粥样硬化斑块进展加快：全面的时间进程分析
Anja R Geisler,Nora Meinhardt,Laura Otto et al.
Anja R Geisler et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) represents a critical progression of metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by hepatic steatosis, inflammation, ...
Caspases and programmed cell death in sepsis: mechanisms, pathophysiology, and therapeutic targets [0.03%]
凯皮素酶和败血症中的程序性细胞死亡：机制、病理生理学及治疗靶点
Haibei He,Xiuli Xie,Lisui Zhou et al.
Haibei He et al.
Sepsis represents a critical medical condition characterized by organ impairment resulting from an uncontrolled systemic reaction to pathogenic infection, posing substantial difficulties in intensive care management. As a key pathological m...
Immune checkpoint crosstalk: CTLA-4/CD80 engagement as a predictor of anti-PD-1/PD-L1 therapy outcome in NSCLC [0.03%]
免疫检查点相互作用：CTLA-4/CD80结合可作为NSCLC患者抗PD-1/PD-L1治疗效果的预测指标
Juan Gumuzio,James Miles,Nicole Quimi et al.
Juan Gumuzio et al.
Background: CTLA-4/CD80 and PD-1/PD-L1 immune checkpoint pathways play critical roles in regulating T-cell activity within the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). While immune checkpoint in...
Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer [0.03%]
APOBEC诱变与结直肠癌基质和内皮生态位重塑及PCDH9相关信号改变之间的关联
Junting Chen,Jiaming Cao,Baosen Zhou et al.
Junting Chen et al.
Background: APOBEC cytidine deaminases generate characteristic TCW-context mutations that diversify cancer genomes, yet their functional impact on colorectal cancer (CRC) progression and the tumor microenvironment (TME) r...