Integrated multi-omics analysis of dampness-heat gout reveals diagnostic biomarkers and therapeutic targets [0.03%]
湿热型痛风的多组学整合分析揭示潜在诊断标志物及治疗靶点研究
Le Yang,Ye Sun,Chuanning Li et al.
Le Yang et al.
Damp-heat gout (DHG) is a highly certified type of disease integrated with syndrome in TCM. The ambiguity of its pathomechanism and the lack of quantifiable indicators limit its clinical accurate diagnosis and treatment. This study aimed to...
MAGL-18c attenuates LPS-induced sepsis-associated liver injury by inhibiting TGF-β/Smad signaling and remodeling medium- and long-chain fatty acid metabolism [0.03%]
MAGL-18c通过抑制TGF-β/Smad信号传导和重塑中链和长链脂肪酸代谢来缓解LPS诱导的脓毒症相关肝损伤
Ying Wang,Meijia Li,Zixia Liang et al.
Ying Wang et al.
Introduction: Sepsis is a major global health burden associated with high mortality and multiple organ dysfunction, among which liver injury is a key determinant of poor prognosis. However, effective therapeutic strategie...
Editorial: Unraveling inflammatory pathways in sickle cell disease: molecular, cellular and translational insights [0.03%]
组约：镰状细胞病的炎症途径：分子、细胞和转化见解
Nicola Conran,Subarna Chakravorty,Renata Sesti-Costa
Nicola Conran
Diversity and function of tumor-associated macrophages in brain metastases: mechanisms and therapeutic prospects [0.03%]
脑转移瘤相关巨噬细胞的多样性和功能：机制和治疗前景
Yingping Ma,Hongyu Wang,Xinman Dou et al.
Yingping Ma et al.
Brain metastasis significantly worsens prognosis in late-stage cancer., with Its treatment hindered by the blood-brain barrier (BBB) and an immunosuppressive tumor microenvironment. Within this environment, tumor-associated macrophages (TAM...
The tumor microenvironment in leukemia: molecular pathways of immune evasion [0.03%]
急性白血病免疫逃逸的分子机制及肿瘤微环境研究进展
Ying Zhu,Jinying Liu,Fang Qiu et al.
Ying Zhu et al.
The interplay between the immune system and leukemia presents major challenges to effective therapy development. This Review examines mechanisms of immune evasion across leukemia subtypes, emphasizing T-cell exhaustion, regulatory T cells (...
Commentary: Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study [0.03%]
评论性文章：预测立体定向放射手术后非小细胞肺癌脑转移患者治疗反应和生存情况的免疫炎症特征：一项回顾性队列研究
Kunpeng Yang,Wenjuan Sun,Bao Wang
Kunpeng Yang
Blinatumomab-driven T-cell activation in αβ and γδ T-cell subsets: insights from in vitro assays [0.03%]
一种体外实验：抗原递呈细胞激活αβ和γδT细胞亚群释放效应分子
Miriam Kelm,Nourhan Nasr,Sonja Bendig et al.
Miriam Kelm et al.
Introduction: Blinatumomab (BLN) is a bispecific T-cell engager that has revolutionized the treatment of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), significantly improving outcomes in both adults and childre...
The evolution of antibody-secreting cell biological exploration: one mouse model at a time [0.03%]
抗体分泌细胞生物学研究的进展：一个动物模型的故事
KimAnh Trang Pioli,Peter Dion Pioli
KimAnh Trang Pioli
Upon antigenic exposure, B cells become activated and undergo differentiation into antibody-secreting cells (ASCs) which secrete thousands of antibodies per second. However, ASCs have shown themselves to be a heterogenous population which p...
MVA-Spike encoding the A subunit of dmLT safely enhances systemic and mucosal immune responses [0.03%]
编码dmLT A亚基的MVA-Spike安全增强全身和粘膜免疫反应
Stephan Rambichler,Ronny Kassub,Rodrigo Carrasco-León et al.
Stephan Rambichler et al.
Introduction: Mucosal immunity provides frontline protection at respiratory, gastrointestinal, and urogenital surfaces, where secretory IgA and tissue-resident T cells such as TH17 limit colonization and early replication...
Hot-yet-suppressed under PD-1 blockade: an RMP-NRF2-PD-L1 axis associated with a reduced proportional response in hepatocellular carcinoma [0.03%]
热点但受抑制：PD-1抑制作用相关的RMP-NRF2-PD-L1轴与肝细胞癌疗效减比效应有关
Mingzhu Zuo,Haiqiang Li,Na Chen et al.
Mingzhu Zuo et al.
Immune checkpoint blockade (ICB) provides therapeutic benefits to a subset of patients with hepatocellular carcinoma (HCC); however, reliable predictors of treatment efficacy remain scarce. This study investigates whether RPB5-mediating pro...