Single-cell transcriptomic profiling reveals innate-like cytotoxic intraepithelial lymphocyte expansion during Salmonella Enteritidis infection in chickens [0.03%]
单细胞转录组分析揭示了鸡感染肠炎沙门氏菌过程中类似天然杀伤的细胞毒性的上皮内淋巴细胞扩增
Shuja Majeed,Bikas Raj Shah,Bikash Aryal et al.
Shuja Majeed et al.
Salmonella is a major foodborne pathogen that causes approximately 1.35 million infections annually in the US and remains a leading cause of poultry-associated foodborne illness. To improve chickens' resistance to this pathogen, it is impor...
Comprehensive characterization of SLC41A3 identifies it as an immune-related prognostic biomarker and therapeutic target in hepatocellular carcinoma [0.03%]
SLC41A3的全面表征使其成为肝细胞癌中与免疫相关的预后生物标志物和治疗靶点
Biyan Gong,Dunfu Cao,Shidong Hu et al.
Biyan Gong et al.
Background: Hepatocellular carcinoma (HCC) represents a highly aggressive cancer associated with substantial patient mortality. Members of the solute carrier (SLC) protein family have been implicated in facilitating tumor...
Senescence-circadian interplay stratifies patient prognosis and reveals immune remodeling heterogeneity in colorectal cancer [0.03%]
衰老-昼夜节律互作揭示结直肠癌患者预后并展现免疫重塑异质性
Li-Zhi Luo,Yu Zhan,Ru-Xiang Bao et al.
Li-Zhi Luo et al.
Background: Colorectal cancer (CRC) exhibits substantial biological and prognostic heterogeneity that is not fully captured by conventional clinicopathological staging, and the interplay between the cellular senescence an...
Integrative multi-omics analysis identifies a CMA-associated heterogeneity risk score and a cDCs-based immune score for robust prognostic stratification in colon cancer with single-center and experimental validation [0.03%]
整合多组学分析识别出一种与CMA相关的异质性风险评分及一种基于cDCs的免疫评分，用于结直肠癌预后分层的单中心和实验验证
Jiaxing Zhang,Xiaodan Zhao,Yong Wang
Jiaxing Zhang
Background: Chaperone-mediated autophagy (CMA) plays an important role in tumor progression and remodeling of the tumor immune microenvironment. However, its functional heterogeneity, immune associations, and clinical sig...
Endoscopic spectrum of autoimmune gastritis across disease stages: a focus on Barrett's esophagus and ME-NBI features [0.03%]
自身免疫性胃炎不同阶段内镜表现：以巴雷特食管和ME-NBI特征为重点
Zhongmian Zhang,Jingna Tao,Liju Zhang et al.
Zhongmian Zhang et al.
Background and aim: Autoimmune gastritis (AIG) is an immune-mediated disorder characterized by corpus-predominant atrophy. While serological markers are useful for screening, they inadequately reflect the dynamic progress...
Immunopathogenesis of antibody-mediated rejection in liver transplantation [0.03%]
肝移植中抗体介导的排斥反应的免疫病理发生学
Bo Luo,Mengyue Wang,Guoyu Chen et al.
Bo Luo et al.
Antibody-mediated rejection (AMR) after liver transplantation (LT) is increasingly recognized as a cause of graft dysfunction, chronic injury, and graft loss, but remains difficult to diagnose because serologic, histologic, and clinical fin...
Global research trends and emerging themes in amino acid deprivation based cancer therapy: a bibliometric and visualization study [0.03%]
基于氨基酸剥夺的癌症治疗的研究趋势和新兴主题：一次文献计量和可视化研究
Xiuli He,Tao Cai,Guoqin Zhang et al.
Xiuli He et al.
Background: Amino acid deprivation and restriction have emerged as metabolically informed anticancer strategies, encompassing dietary interventions, enzyme-mediated depletion, and pathway-targeted approaches. The fast-gro...
Efficacy and mechanisms of immune checkpoint inhibitors in late-stage EGFR-mutated non-small cell lung cancer following targeted therapy resistance [0.03%]
EGFR突变非小细胞肺癌经靶向治疗耐药后免疫检查点抑制剂的有效性和机制研究
Jiling Niu,Wang Jing,Zongkai Liu et al.
Jiling Niu et al.
Currently, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) represent the standard first-line treatment for advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, as the disease progresses, targeted resist...
STAT6 inhibition of M2 macrophages suppresses tumor growth by modulating the tumor microenvironment in colon cancer model [0.03%]
STAT6抑制M2型巨噬细胞通过调节肿瘤微环境抑制结直肠癌的发展
Geumseong Yeun,Ik-Hwan Han,Ilseob Choi et al.
Geumseong Yeun et al.
Background: Colorectal cancer (CRC) progression is strongly influenced by the tumor microenvironment (TME), where M2 tumor-associated macrophages (TAMs) establish an immunosuppressive milieu that promotes tumor growth, an...
Overcoming chemoresistance in esophageal cancer with synergistic strategies [0.03%]
协同策略克服食管癌化疗耐药性问题
Chunxiao Gao,Ting Zhang,Guangyuan Li et al.
Chunxiao Gao et al.
Esophageal cancer is a globally prevalent malignancy with poor clinical outcomes. Chemotherapy remains an effective strategy for esophageal cancer. However, its effectiveness is substantially limited by chemoresistance, which arises from bo...