Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma [0.03%]
Yuxiang Chi,Guoyuan Ma,Qiang Liu et al.
Yuxiang Chi et al.
Background: Metabolic reprogramming within the tumor microenvironment plays a pivotal role in tumor progression and therapeutic responses. Nevertheless, the relationship between aberrant glutathione (GSH) metabolism and t...
Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis [0.03%]
Chunyang Li,Haiyan Xue,Lihe Chen et al.
Chunyang Li et al.
Sepsis is a life-threatening condition caused by a dysregulated host response to infection and is one of the leading causes of morbidity and mortality worldwide. Glycosylation is one of the key modes of protein modification, affecting prote...
A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies [0.03%]
亲和力成熟 simulation 的范式转变以激发广泛中和抗体
Fahsai Nakarin,Kayla G Sprenger
Fahsai Nakarin
Broadly neutralizing antibodies (bnAbs) offer a promising route to protect against rapidly evolving pathogens such as HIV, influenza, and SARS-CoV-2, yet eliciting them through vaccination remains a significant challenge. A key to this prob...
Linnéa Pettersson,Sofia Westerling,Hamid Ramezanali et al.
Linnéa Pettersson et al.
This study presents the analytical performance of a new Next-Generation Sequencing (NGS) assay designed to detect Human Leukocyte Antigen (HLA) loss. Unlike existing methods, this assay offers increased sensitivity, broader applicability, a...
Effective venetoclax treatment for indolent T-cell lymphoma of the gastrointestinal tract: a case report and literature review [0.03%]
有效使用Venetoclax治疗胃肠黏膜T细胞淋巴瘤1例及相关文献复习
Ji-Mo Jian,Hong-Yuan Hao,Cheng-Lu Yuan et al.
Ji-Mo Jian et al.
Indolent T-cell lymphoma of the gastrointestinal tract (iTCL-GI) is rare, lacking standardized treatments. We report a successful venetoclax treatment in one patient with indolent T-cell lymphoma of the gastrointestinal tract. A 35-year-old...
Interventional treatment combined with immunotargeted therapy in unresectable combined hepatocellular-cholangiocarcinoma: a real-world retrospective cohort study [0.03%]
不可切除的肝细胞癌-胆管癌联合癌介入治疗联合免疫靶向治疗的真实世界回顾队列研究
Yan-Song Lin,Li-Yan Wu,Li-Hui Lin et al.
Yan-Song Lin et al.
Background: Evidence-based treatment for unresectable combined hepatocellular-cholangiocarcinoma (cHCC-CCA) has not been established. This study aimed to assess the effectiveness and safety of interventional treatment com...
Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors [0.03%]
分泌Relaxin-2的CAR-T细胞在富含基质的异种移植肿瘤中表现出增强的功效
Hisataka Ogawa,Tomoya Ekawa,Yu Mizote et al.
Hisataka Ogawa et al.
Introduction: Chimeric antigen receptor (CAR)-T cell therapy has demonstrated notable efficacy in treating hematological malignancies. Although it has shown promise in the clinical management of solid tumors, poor outcome...
Identification and validation of genes related to stem cells and telomere maintenance mechanisms as biomarkers for breast cancer [0.03%]
识别并验证与干细胞及端粒维持机制相关的乳腺癌生物标志物基因及其验证
Shuang Zhen,Lifeng Huang,Qiannan Zhu et al.
Shuang Zhen et al.
Background: Stem cell-related genes (SCRGs) and telomere maintenance mechanism-related genes (TMMRGs) are pivotal in breast cancer (BC) pathogenesis by facilitating tumor cell proliferation and self-renewal. This study em...
Therapeutic mechanisms of polysaccharides in the management of rheumatoid arthritis: a comprehensive review [0.03%]
糖类治疗机制在类风湿性关节炎管理中的作用：全面综述
Wenlong Liu,Youqian Kong,Xiaoyu Wang et al.
Wenlong Liu et al.
Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and destruction of articular cartilage and bone, which seriously affects patients' quality of life. In recent years, with the in-depth research...
Editorial: Environmental stressors and aquatic animal immune system function [0.03%]
编者按：环境压力因素与水生动物免疫系统功能
Christopher J Martyniuk,Erchao Li,Matthew L Rise
Christopher J Martyniuk