CT-based radiogenomic prediction of ICAM1 and RAET1E as biomarkers of NK cytotoxicity in clear cell renal cell carcinoma [0.03%]
基于CT的影像基因组预测ICAM1和RAET1E作为透明细胞肾细胞癌自然杀伤细胞毒性的生物标志物
Xinwei Ma,Jiao Yang,Xusheng Qian et al.
Xinwei Ma et al.
Introduction: This study aims to develop a noninvasive CT-based radiogenomic framework to estimate imaging-associated biomarkers related to natural killer (NK) cell cytotoxicity in clear cell renal cell carcinoma (ccRCC)....
Diagnostic value of CSF CXCL8 combined with total protein for neurosyphilis: a logistic regression and ROC analysis [0.03%]
CSF中CXCL8联合总蛋白对神经梅毒的诊断价值：逻辑回归和ROC分析
Yan Zhang,Yujiao Jin,Yuan Liu et al.
Yan Zhang et al.
Background: Neurosyphilis has resurged globally, presenting a significant public health threat, yet challenges in early diagnosis persist. This study aims to evaluate the diagnostic value of C-X-C motif chemokine ligand 1...
Fecal microbiota transplantation reduces inflammation and modulates gene expression in HIV-infected double humanized-BLT (dHu-BLT) mice on antiretroviral therapy [0.03%]
粪便微生物移植可减轻HIV感染的双功能人类BLT小鼠在接受抗逆转录病毒治疗过程中的炎症并调节基因表达
Saroj Chandra Lohani,Chi Zhang,Subhra Mandal et al.
Saroj Chandra Lohani et al.
Introduction: Persistent immune activation and inflammation remain significant barriers to managing comorbidities in people living with HIV (PLWH) on suppressive antiretroviral therapy (ART). While ART substantially reduc...
Cannabinoid receptor expression profiling in lymphocyte subsets reveals clinically relevant immune patterns in SLE [0.03%]
cannabinoid受体表达谱在淋巴细胞亚群中的分型揭示了SLE的临床相关免疫模式
Angie M Rosero,Lady J Rios-Serna,Carlos A Cañas
Angie M Rosero
Introduction: This study aimed to determine the expression of cannabinoid receptors in lymphocytes from patients with systemic lupus erythematosus (SLE) compared with healthy controls, and to evaluate whether receptor exp...
Inflammatory protein mediators linking gut microbiota to degenerative lumbar spine disorders: cross-disease genetic evidence [0.03%]
连接肠道微生物群和腰椎退行性疾病的相关炎症蛋白介质：跨疾病遗传证据
Yongfu Lou,Daoyi Ma,Qingquan Gan et al.
Yongfu Lou et al.
Background: Degenerative lumbar spine disorders (DLSD), including intervertebral disc disorders (IDD), degenerative spondylolisthesis, and lumbar spinal stenosis (LSS), are major contributors to low back pain and disabili...
Revisiting down syndrome through the lens of interferonopathy and innate immune dysregulation [0.03%]
从干扰素病和固有免疫失调的角度重新审视唐氏综合症
Guangfu Wang,Weili Shi,Shixiu Liao et al.
Guangfu Wang et al.
Down syndrome (DS), caused by trisomy 21, has long been viewed primarily as a neurodevelopmental disorder. However, increasing evidence indicates that it is also associated with pervasive immune dysregulation, including chronic inflammation...
Neurocardiac consequences of traumatic brain injury: integrating neuroimmune, autonomic, and cerebrovascular mechanisms [0.03%]
创伤性脑损伤的心血管神经后遗症：整合神经免疫、自主神经和脑血管机制
Claymore T Gumbo,Mikaela A Barbour,Zachary M Weil
Claymore T Gumbo
Traumatic brain injury (TBI) is increasingly recognized as a systemic disorder with consequences that extend beyond the central nervous system (CNS) to include clinically relevant cardiac dysfunction. Clinical and experimental evidence indi...
Baicalin and valproic acid synergistically induce hepatocellular carcinoma cell apoptosis via ROS-mediated PTEN upregulation [0.03%]
山柰酚和丙戊酸联合诱导肝癌细胞凋亡的分子机制研究
Zhiqiang Ni,Xianzhuo Jiang,Ying Zhou et al.
Zhiqiang Ni et al.
Background and objective: The prognosis of liver cancer remains exceedingly poor. The therapeutic potential of baicalin (BAI), a natural bioactive compound, in treating liver cancer is significantly limited by its low bio...
Mycophenolate mofetil for corticosteroid-resistant immune-related cystitis associated with tislelizumab: a case report [0.03%]
利妥昔单抗相关激素耐药型免疫性膀胱炎使用吗替麦考酚酯治疗的病例报告
Lingping Kong,Fanlu Meng,Jing Yang et al.
Lingping Kong et al.
Immune-related cystitis is an uncommon immune-related adverse event (irAE) linked to immune checkpoint inhibitors (ICIs), and managing cases refractory to corticosteroids remains clinically challenging due to the lack of standardized treatm...
Case Report: Tocilizumab in pediatric febrile infection-related epilepsy syndrome [0.03%]
托珠单抗治疗儿童发热感染相关性癫痫综合征病例报告
Lingyu Pang,Xuefang Liu,Suzhen Sun et al.
Lingyu Pang et al.
Background and purpose: We describe the clinical characteristics and the therapeutic effect of tocilizumab with Febrile Infection-Related Epilepsy Syndrome (FIRES). FIRES is characterized by super refractory status epilep...