The contribution of BTK signaling in myeloid cells to neuroinflammation [0.03%]
BTK信号促进髓系细胞在神经炎症中的作用
Claudia Bassani,Marta Molinari,Valentina Romeo et al.
Claudia Bassani et al.
Introduction: Bruton's tyrosine kinase (BTK) is a member of the TEC family of non-receptor tyrosine kinases expressed in cells of hematopoietic origin, including B lymphocytes and myeloid cells. Selective BTK inhibitors (...
Wuhan strain of SARS-CoV-2 triggers activation of immune evasion machinery similar to the one operated by cancer cells [0.03%]
武汉新型冠状病毒引发的免疫逃逸机制与癌细胞的相似
Maryam Abooali,Inna M Yasinska,Gauri Thapa et al.
Maryam Abooali et al.
In the last 2 years, there has been an increasing concern that SARS-CoV-2 infection may represent a marker of undiagnosed cancers. A potential connection between COVID-19/long COVID and malignant transformation/cancer progression was report...
Anna Ewa Kedzierska,Daria Lorek,Anna Slawek et al.
Anna Ewa Kedzierska et al.
Problem: Unbalanced production of pro- and anti-inflammatory cytokines by immune cells is a hallmark of endometriosis. IL-24, a member of the IL-10 family, is a pleiotropic cytokine produced by both non-immune cells like ...
Wanting Zhu,Tineke Vanderhaeghen,Steven Timmermans et al.
Wanting Zhu et al.
Acute iron overload leads to ferroptosis, in a mouse model of FeSO4 challenge causing lethal shock, associated with inflammation and multiple organ failure (MOF). We investigated molecular aspects causing this phenomenon upon FeSO4 overload...
Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma [0.03%]
在黑色素瘤中的鉴定和验证与KRAS-巨噬细胞相关基因特征作为预后生物标志物和潜在治疗靶点
Beichen Cai,Qian Lin,Ruonan Ke et al.
Beichen Cai et al.
Introduction: Skin cutaneous melanoma (SKCM) is a highly aggressive form of cancer with poor prognosis, characterized by significant molecular and immune heterogeneity. The activation of KRAS signaling pathways is implica...
Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation [0.03%]
评估小鼠复合移植受体对部分hindlimb的免疫原性
Jia Hui Angela Sun,Samantha Ligi,Felor Biniazan et al.
Jia Hui Angela Sun et al.
Background: Vascularized composite allotransplantation (VCA) offers a promising solution for restoring function in patients with severe tissue trauma, yet acute rejection remains a major hurdle. Acute rejection is driven ...
Clinical and biochemical characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia [0.03%]
临床和生化表征：贡达尔大学综合医院乙肝表面抗原阳性伴或不伴有幽门螺旋杆菌感染的患者特征分析（埃塞俄比亚西北部）
Mekuriaw Belayneh,Bantayehu Addis Tegegne,Mulualem Lemma et al.
Mekuriaw Belayneh et al.
Background: Hepatitis B virus (HBV) is a major global public health issue and the most common etiology of chronic liver disease (CLD). The relationship between Helicobacter pylori and HBsAg+ patients was not well investig...
Christopher T Turner
Christopher T Turner
Granzyme K (GzmK) is an immune-secreted serine protease typically expressed at low levels but elevated in response to tissue injury and disease. Known as an orphan granzyme due to limited scientific investigation, this tryptase is being red...
Landscape analysis of matrix metalloproteinases reveals key prognostic markers for prostate cancer [0.03%]
矩阵金属蛋白酶的景观分析揭示了前列腺癌的关键预后标志物
Wei Li,Xi Wei,Ying Yu et al.
Wei Li et al.
Background: Prostate cancer (PCa) is the most common male malignancy and significantly impairs patient's survival. Matrix metalloproteinases (MMPs) play a crucial role in tumor progression, yet the comprehensive role of M...
Intratumoral immunotherapy prior to cancer surgery, a promising therapeutic approach [0.03%]
肿瘤手术前的瘤内免疫治疗：一种有前景的治疗策略
Kevine Silihe Kamga,Steven Fiering
Kevine Silihe Kamga
Cancer immunotherapy has made astonishing progress in the last 10-15 years, and the rate of progress is accelerating. However, only 20 to 40% of patients benefit from this therapy with most immunotherapy applied post discovery of metastatic...