Complete recovery after complement factor I deficiency associated fulminant acute hemorrhagic leukoencephalitis: a case report [0.03%]
补体因子I缺乏相关的急性出血性白质脑炎的完全恢复：病例报告
Fanni Szumutku,Léna Szabó,Zoltán Liptai et al.
Fanni Szumutku et al.
Introduction: Acute hemorrhagic leukoencephalitis (AHLE) is a rare, fulminant neuroinflammatory disease with high mortality rate. It most often occurs after infections; however, the exact etiology of the disease remains u...
CAR-T cell therapy for glioblastoma: insight from mathematical modeling [0.03%]
数学建模指导的针对胶质母细胞瘤的CAR-T细胞治疗研究新进展
Magdalena Szafrańska-Łęczycka,Zuzanna Szymańska,Monika J Piotrowska et al.
Magdalena Szafrańska-Łęczycka et al.
Introduction: Glioblastoma is a rare, aggressive brain tumor marked by high therapeutic resistance, poor prognosis, and limited treatment options. Emerging immunotherapies, particularly Chimeric Antigen Receptor (CAR) T-c...
Adaptive dynamic ϵ-simulated annealing algorithm for tumor immunotherapy [0.03%]
自适应动态模拟退火算法在肿瘤免疫治疗中的应用
Xiaoyan Sun,Ying Jiang
Xiaoyan Sun
Introduction: Personalized cancer treatment requires precise scheduling of multiple therapeutic agents under biological constraints. Optimizing such regimens is especially challenging due to the nonlinear dynamics of tumo...
Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors [0.03%]
结直肠癌浸润的NK细胞分析揭示微卫星不稳定性肿瘤中的组织驻留PD-1+NK细胞景观分析揭示微卫星不稳定肿瘤中存在组织驻留PD-1+NK细胞
Valentina Obino,Chiara Giordano,Simona Carlomagno et al.
Valentina Obino et al.
Background: Natural killer (NK) cells are innate lymphocytes endowed with potent cytotoxic activity. The presence of tumor-associated NK cells has been correlated with better prognosis in several solid tumors including co...
The emerging relationship between mucosal-associated invariant T cell populations and the onset and progression of type 1 diabetes [0.03%]
黏膜相关不变T细胞群与1型糖尿病的发生和发展的关系不容忽视
Devin R Fraser,Andrew W Stadnyk
Devin R Fraser
Type 1 diabetes (T1D) is a chronic autoimmune disorder characterized by autoreactive CD8+ T cells that destroy insulin-producing pancreatic β-cells. CD8+ T cells are unlikely to be the only cells involved in diabetes. Relatively recently d...
The processed Sanguisorba officinalis L. triterpenoids prevent colon cancer through the TNF- α/NF-κB signaling pathway, combined with network pharmacology, molecular simulation dynamics and experimental verification [0.03%]
网络药理学、分子动力学结合实验验证丹参素防治结肠癌的机制研究
Chunli Gan,Yuanqiu Mu,Shah Syed Faizan Ali et al.
Chunli Gan et al.
Background: Sanguisorba officinalis L. (S.L.), a traditional Chinese medicine from the Rosaceae family, is recognized for its rich content of triterpenoids, which are known for their antioxidant, anti-inflammatory, and an...
The functional and clinical significance of nucleoporin NUP153 across human cancers: a systematic study based on multi-omics analysis and bench work validation [0.03%]
人癌基因和临床调控下的核孔蛋白NUP153功能及意义：基于蛋白质组学分析的系统性研究及实验验证
Youfu He,Qing Wang,Zhaorui Wang et al.
Youfu He et al.
Background: Cancer is a group of highly heterogeneous malignant diseases, and early diagnosis plays a crucial role in improving patient outcomes. Nucleoporins, including Nucleoporin (NUP)153, are involved in key cellular ...
Neutrophil-lymphocyte and platelet-lymphocyte ratios as systemic inflammatory biomarkers for atopic dermatitis in US adults: a cross-sectional NHANES study revealing subgroup heterogeneity [0.03%]
美国成人系统性炎症标志物中性粒细胞淋巴细胞比值和血小板淋巴细胞比值作为过敏性皮炎的生物标志物：来自NHANES横断面研究的结果显示亚组异质性
Xuanlin Chen,Xiangyu Yang,Min Zhang et al.
Xuanlin Chen et al.
Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are systemic inflammation markers, but their association with adult atopic dermatitis (AD) remains underexplored. ...
Prostate cancer immunotherapy-based strategies: an updated review emphasizing immune checkpoint inhibitors [0.03%]
基于免疫检查点抑制剂的前列腺癌免疫治疗策略：最新综述
Hua Lu,Zhaojun Teng,Jiajia Wang et al.
Hua Lu et al.
Prostate cancer (PC) is one of the most common cancers that is diagnosed in about 10-15% of men in old age. It seems that the current treatments are not effective, and this leads to prostate cancer becoming the second-deadliest cancer. Trea...
Xiaorui Gong,Xueying Wang,Jing Jin et al.
Xiaorui Gong et al.
Chemokines are key molecules that regulate immune cell migration and play critical roles in the tumor microenvironment. In lung cancer, chemokine dysregulation is closely linked to tumor progression. They promote immune cell infiltration an...