Myelin oligodendrocyte glycoprotein antibody-associated cerebral cortical encephalitis: a case report highlighting diagnostic challenges and therapeutic implications [0.03%]
髓鞘少突胶质细胞糖蛋白抗体相关脑炎：一例报道并探讨诊断困难及治疗意义
MengChan Liu,DaWei Li
MengChan Liu
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) encompasses a spectrum of inflammatory demyelinating disorders of the central nervous system (CNS). Recognized clinical phenotypes include optic neuritis (ON), tr...
Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis [0.03%]
炎症驱动的periostn在ECRS中对组织结构完整性和骨髓炎具有相反的影响
Soo-In Kim,Min-Seok Rha,Jinsun Kim et al.
Soo-In Kim et al.
Introduction: Eosinophilic chronic rhinosinusitis (ECRS) is a severe form of chronic rhinosinusitis characterized by type 2 inflammation, tissue remodeling, and bone thickening, known as osteitis. Periostin, a matricellul...
Identification and validation of NETs-related biomarkers in active tuberculosis through bioinformatics analysis and machine learning algorithms [0.03%]
通过生物信息学分析和机器学习算法识别并通过验证NETs相关结核病活动期生物标志物
Shengfang Xia,Qi An,Rui Lin et al.
Shengfang Xia et al.
Introduction: Diagnostic delays in tuberculosis (TB) threaten global control efforts, necessitating early detection of active TB (ATB). This study explores neutrophil extracellular traps (NETs) as key mediators of TB immu...
High NK cell counts at day 90 predict improved survival in event-free patients after T-cell depleted allogeneic stem cell transplantation [0.03%]
allo-HSCT后T细胞清除型事件清零患者的生存期预测及90天NK细胞计数较高的患者生存期改善状况
Andrej Pešić,Nevena Bešević,Nicolaus Kröger et al.
Andrej Pešić et al.
Introduction: Immune reconstitution (IR) after allogeneic stem cell transplantation has been highlighted as pivotal in achieving favorable long-term outcomes by influencing the rates of infection, graft versus host diseas...
CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions [0.03%]
CCR5基因编辑与HIV免疫治疗：现状、挑战及未来方向
Jia-Wen Wang,Jia-Hui Liu,Jian-Jun Xun
Jia-Wen Wang
Human immunodeficiency virus (HIV) infection remains a major global public health challenge. Although highly active antiretroviral therapy (HAART or ART) can effectively control viral replication, it fails to eradicate latent viral reservoi...
N-glycosylation patterns of plasma immunoglobulin G in anti-synthetase syndrome disease [0.03%]
抗合成酶综合征疾病中血浆免疫球蛋白G的N-聚糖特征分析
Jing Zhao,Yanhong Li,Yingying Ling et al.
Jing Zhao et al.
Introduction: Anti-synthetase syndrome (ASS) is a subtype of idiopathic inflammatory myopathy (IIM) characterized by characteristic rash, myositis, and interstitial lung disease (ILD). The etiology of ASS is unknown, and ...
Case Report: Hepatic sarcoidosis-like reaction from neoadjuvant pembrolizumab in early-stage triple-negative breast cancer [0.03%]
个例报告：帕博利珠单抗新辅助治疗早期三阴性乳腺癌导致的肝结节病样反应
Yujing Tan,Yu Wang,Xiaoyan Liu et al.
Yujing Tan et al.
Drug-induced sarcoidosis-like reaction (DISR) is a rare adverse event associated with immunotherapy. Currently, there is no standardized treatment protocol for DISR linked to immune checkpoint inhibitors (ICIs). This study presents a case o...
Harnessing extracellular vesicles to tame inflammation: a new strategy for atherosclerosis therapy [0.03%]
利用细胞外囊泡调控炎症反应成为治疗动脉粥样硬化的新策略
Jiawei Li,Tianliang Wen,Xiaoran Li et al.
Jiawei Li et al.
Atherosclerosis (AS) is a chronic inflammatory disease driven by immune dysregulation and vascular inflammation. Extracellular vesicles (EVs) play pivotal roles in intercellular communication, modulating immune responses and inflammatory ca...
P-glycoprotein expression skews mitochondrial dye measurements in T cells [0.03%]
P-糖蛋白的表达使T细胞中的线粒体染料测定产生偏差
Sophia P M Sok,Jianan Cheng,Klaudia Strucinska et al.
Sophia P M Sok et al.
Assays to monitor metabolic parameters of immune cells at a single cell level provide efficient means to study immunometabolism. We show here that staining intensity of mitochondria targeting probes in T cells is dramatically influenced by ...
A comprehensive welfare scoring system for graft versus host disease clinical assessment in humanised mouse models used for pharmaceutical research [0.03%]
全面的福利评分系统用于人源化小鼠模型移植物抗宿主病的临床评估在药物研究中的应用
Alice Nowak,Rebecca Marlow,Kelli Ryan et al.
Alice Nowak et al.
Immuno-oncology drug discovery increasingly relies on humanised mouse models of cancer due to limitations of murine surrogate tools and differences between mouse and human immune systems. Graft-versus-Host Disease (GvHD) is a significant co...