The role of MCT1 in tumor progression and targeted therapy: a comprehensive review [0.03%]
MCT1在肿瘤发生发展及靶向治疗中的作用：综述文章
Zheng Xu,Xuemei Wang,Hongjing Cheng et al.
Zheng Xu et al.
Overexpression of monocarboxylate transporter 1 (MCT1) in tumor cells is often associated with poor prognosis. The established mechanisms through which MCT1 and its mediated lactate transport drive tumor progression are manifold. The classi...
A novel, rapid, and practical prognostic model for sepsis patients based on dysregulated immune cell lactylation [0.03%]
一种基于免疫细胞乳酰化的脓毒症患者新型、快速和实用的预后模型
Chang Li,Mei He,PeiChi Shi et al.
Chang Li et al.
Background: Sepsis is a global health burden characterized by high heterogeneity and uncontrolled immune response, with a notable lack of reliable methods for early prognosis and risk stratification. Epigenetic modificati...
Jakub Motor,Agata Gajewska,Krzysztof Cienkowski et al.
Jakub Motor et al.
IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition characterized by the infiltration of IgG4-positive plasma cells in affected tissues, leading to fibrosis and progressive organ dysfunction. This review explores the ep...
Interplay of trauma-triggered auto-inflammation and T-cell auto-reactivity in posttraumatic dystrophy [0.03%]
创伤诱发的自身炎症和T细胞自身免疫在创伤后萎缩中的相互作用
Egmont Scola
Egmont Scola
Damage-associated molecular patterns (DAMPs) cause sterile auto- inflammation after a traumatic incident in human tissues via innate immunity. The auto-reactivity of natural killer T cells (NK-T cells) instigated by DAMP-activated exocytosi...
The differential role of IL-33 and IL-38 in prostate cancer, contradictory roles [0.03%]
前列腺癌中IL-33和IL-38的不同作用及其矛盾之处
Runfen Ban,Shanshan Gao,Bin Zhou et al.
Runfen Ban et al.
Prostate cancer (PCa) is still as a major cause of morbidity and mortality in men at the global level, highlighting the necessity for improved diagnostic and therapeutic strategies beyond current PSA screening limitations. This mini-review ...
Immunoglobulin Y antibodies against colonization-related genes block the growth and infection of Helicobacter pylori [0.03%]
抗定植基因的免疫球蛋白Y抗体可阻断幽门螺旋杆菌的生长和感染
Shiyuan Deng,Xiaoling Luo,Yunxiao Du et al.
Shiyuan Deng et al.
Introduction: Immunoglobulin Y (IgY) has emerged as a promising antibody therapy for the eradication of Helicobacter pylori (H. pylori) independent of antibiotics. However, the roles and differences of IgY antibodies targ...
Targeting fibroblast activation protein in rheumatoid arthritis: from molecular imaging to precision therapeutics [0.03%]
针对类风湿关节炎的成纤维细胞活化蛋白：从分子影像到精确诊疗
Yupeng Huang,Yang Wu,Huan Liu et al.
Yupeng Huang et al.
Rheumatoid arthritis (RA), a chronic inflammatory disorder characterized by synovitis and joint destruction, remains a global health challenge. Activated fibroblast-like synoviocytes (FLS), which play a crucial role in the progression of RA...
Recent advances in novel tumor immunotherapy strategies based on regulating the tumor microenvironment and immune checkpoints [0.03%]
基于调节肿瘤微环境和免疫检查点的新型肿瘤免疫治疗策略的研究进展
Hanhui Jing,Yan Gao,Zongsheng Sun et al.
Hanhui Jing et al.
Tumor immunotherapy, a novel and rapidly progressing cancer treatment, has experienced remarkable advancements over recent years. It focuses on augmenting the patient's immune defenses and remodeling the immune microenvironment (IME) of tum...
The dual regulatory effects of intestinal microorganisms and their metabolites in gouty arthritis pathogenesis: a balance between promotion and inhibition [0.03%]
肠道菌群及其代谢物在痛风性关节炎发病机制中的双重调控作用：促进与抑制间的平衡关系研究
Peng Qi,Longcan Li,Jianrong Zhang et al.
Peng Qi et al.
Gout is an arthritis characterized by the deposition of urate crystals, often accompanied by robust inflammatory responses. The gut microbiome profoundly influences gout pathogenesis, progression, and management by affecting uric acid metab...
Editorial: Combination immunotherapy and immune response assessment of brain tumours [0.03%]
编辑来稿：脑肿瘤的联合免疫治疗和免疫反应评估
Haihui Jiang
Haihui Jiang