Ahmed B Alarabi,Fatima Z Alshbool,Fadi T Khasawneh
Ahmed B Alarabi
Smoking is a major cause of morbidity and mortality, resulting in an increased risk of cardiovascular, respiratory, inflammatory, and degenerative diseases. In this review, we highlight the complex interactions between smoking and activatio...
Exosomal proteins: new targets for early diagnosis and treatment of cancer [0.03%]
外泌体蛋白：癌症早期诊断和治疗的新靶标
Haibin Shen,Meijin Liu,Wentai Yang et al.
Haibin Shen et al.
Exosomes are nanoscale, double-membraned vesicles released by a variety of living cells. A wide variety of cargoes, including proteins, DNA and RNA, are transported by exosomes to target cells, thereby transmitting biological signals. In ad...
A systems immunology perspective on gout pathogenesis and its precision-targeted treatment strategies [0.03%]
系统免疫学视角下痛风发病机制与精准治疗策略研究进展
Zilong Chen,Qian Guo,Yanzhao Zhang et al.
Zilong Chen et al.
Gouty arthritis (GA) is a sterile inflammatory disease driven by monosodium urate (MSU) crystal deposition, which activates innate and adaptive immune responses. Key mechanisms involve NLRP3 inflammasome activation, cytokine release (IL-1β...
Jianfeng Han,Youwei Wang,Godfrey Chi-Fung Chan et al.
Jianfeng Han et al.
Natural killer group 2 D (NKG2D) receptor, one of the activation receptors on NK cells, has gained increasing attention in recent years because its ligands are widely expressed in most cancers. Naturally, NKG2D reacts to 8 different stress-...
Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait [0.03%]
进行性肺纤维化生物标志物的预测：形态、细胞因子谱和临床特征
Nicol Bernardinello,Federica Pezzuto,Lauren D&#x;Sa et al.
Nicol Bernardinello et al.
Objective: The term progressive pulmonary fibrosis (PPF) refers to a specific disorder that becomes worse despite optimal treatment. The pathogenic explanation of this progressive worsening is still to be found. In this s...
Bridging aging, immunity, and atherosclerosis: novel insights into senescence-related genes [0.03%]
衰老、免疫和动脉粥样硬化之间的联系：与衰老相关的基因的新见解
Yan Lu,Rong Yuan,Qiqi Xin et al.
Yan Lu et al.
Background: Atherosclerosis (AS) is a chronic disease whose risk increases with age. Identifying reliable biomarkers and understanding the interactions between immune senescence and AS may provide important therapeutic op...
SNRPB2 facilitates esophageal squamous cell carcinoma oncogenesis and progression via E2F4 stabilization [0.03%]
SNRPB2通过稳定E2F4促进食管鳞状细胞癌的发病和进展
Feng Xu,Chen-Cheng Zhu,Chen Lu et al.
Feng Xu et al.
Introduction: Esophageal cancer (ESCA) is a highly aggressive malignancy with poor prognosis. Small nuclear ribonucleoprotein polypeptide B2 (SNRPB2) is a core component of the spliceosome involved in pre-mRNA splicing. H...
Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies [0.03%]
新型人源单克隆抗体可有效预防STAT1小鼠感染致死性HAdV-4
Xinyi Zhang,Zhongge Zhu,Peijie Zhai et al.
Xinyi Zhang et al.
Introduction: Human adenovirus serotype 4 (HAdV-4) is an epidemic pathogen associated with severe acute respiratory disease (ARD) in both pediatric and adult populations. Currently, no available vaccine or therapeutic int...
PLK1 in cancer therapy: a comprehensive review of immunomodulatory mechanisms and therapeutic opportunities [0.03%]
PLK1在癌症治疗中的免疫调节机制及治疗机会的全面回顾
Weihao Wang,Rui Zhao,Yahui Wang et al.
Weihao Wang et al.
PLK1 plays a crucial role in cell cycle regulation and cancer development, and its dysregulation has been implicated in the prognosis of a variety of malignancies. The potential of PLK1 inhibitors as cancer therapeutics has been extensively...
The fibrin-derived peptide FX06 protects human pulmonary endothelial cells against the COVID-19-triggered cytokine storm [0.03%]
纤维蛋白衍生的肽FX06保护人类肺内皮细胞免受COVID-19触发的细胞因子风暴侵害
Zhiran Wang,Dmitrii Lebedev,Simeng Li et al.
Zhiran Wang et al.
Introduction: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major health emergency since its emergence in late 2019. Endothelial dysfunction is a h...