Sex-based immunological differences in multisystem inflammatory syndrome in children: potential role of TR3-56 cells for pathogenesis, diagnosis, and therapy [0.03%]
儿童多系统炎症综合征的性别免疫差异及其潜在致病、诊断和治疗作用的TR3-56细胞机制研究
Flavia Carriero,Monica Gelzo,Valentina Rubino et al.
Flavia Carriero et al.
Multisystem Inflammatory Syndrome in Children (MIS-C) is characterized by immune dysregulation, exhibiting clinical and immunological features reminiscent of autoimmune processes, although its underlying mechanisms remain incompletely under...
Immune profiling of pediatric germ cell tumors identifies key cell populations and novel therapeutic targets [0.03%]
儿童生殖细胞肿瘤的免疫谱分析鉴定出关键的细胞群体和新颖的治疗靶点
Lenilson Silva,Ingridy Izabella Vieira Cardoso,Marcelo Cavalcanti da Cruz et al.
Lenilson Silva et al.
Introduction: Pediatric germ cell tumors (GCTs) are rare malignancies, comprising only about 3% of childhood cancers. Despite surgery and platinum-based chemotherapy being mainstays of treatment, their effectiveness varie...
Editorial: Innovative immunotherapy strategies for enhanced treatment of Hodgkin and non-Hodgkin lymphomas [0.03%]
论点：创新的免疫治疗策略可提高霍奇金淋巴瘤和非霍奇金淋巴瘤的治疗效果
Michael J Robertson,Eric Vivier,Penny Fang
Michael J Robertson
Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis [0.03%]
犬内脏利什曼病的脾巨噬细胞功能特征及其在免疫发病机制中的作用
Tainã Luís de Souza,Marta de Almeida Santiago,Francini Neves Ribeiro et al.
Tainã Luís de Souza et al.
Introduction: Visceral leishmaniasis (VL) represents a major public health challenge, with the spleen frequently identified as one of the primary target organs. Dogs recognized as urban reservoir hosts, commonly harbor ch...
Risk of new-onset and recurrent uveitis with different biologics for ankylosing spondylitis: a network meta-analysis [0.03%]
肿瘤溶解综合征的预防和治疗：SLE患者妊娠期使用的羟氯喹的安全性探究
Xu Zhao,Qingqing Xie,Xinyi He et al.
Xu Zhao et al.
Background: Uveitis is a common extra-articular manifestation of ankylosing spondylitis (AS), and a systematic analysis of the effects of biologics on new-onset and recurrent uveitis is clinically important. ...
Case Report: Durable complete response of advanced-stage hepatocellular carcinoma to DEB-TACE combined with lenvatinib and camrelizumab [0.03%]
个例报告：DEB-TACE联合仑伐替尼和卡瑞利珠单抗治疗晚期肝细胞癌获得长期完全缓解
Baiguo Xu,Yufeng Cui,Ning Wang et al.
Baiguo Xu et al.
Background: Hepatocellular carcinoma (HCC) with lung metastases is associated with a poor prognosis due to limited effective treatment options. Emerging evidence suggests that combining locoregional therapy, multi-kinase ...
Overexpression of CTLA-4 and fibronectin, and lower expression of CD137 (4-1BB) is associated with brain metastasis of primary skin melanomas. An analysis of local immune response by digital spatial profiling [0.03%]
CTLA-4和纤连蛋白的过表达及CD137(4-1BB)低表达与原发性皮肤黑色素瘤脑转移相关。基于数字空间分析技术对局部免疫反应的研究
Shiva Najjary,Nur Al Amery,Mengqi Huang et al.
Shiva Najjary et al.
Background: To discover immune response-associated gene expressions related to brain metastases of skin melanomas, we analyzed a group of fifteen primary skin melanomas consisting of five tumors from patients who did not ...
Tumor-suppressing multi-enterobacteria and PD-1/PD-L1 immune checkpoint inhibitor combination improves the outcome of hepatocellular carcinoma therapy [0.03%]
肿瘤抑制多肠杆菌与PD-1 / PD-L1免疫检查点抑制剂联合改善肝细胞癌治疗效果
Dongjuan Wu,Yaohua Fan,Mingsheng Zhang et al.
Dongjuan Wu et al.
Objective: Programmed death 1 (PD-1) and its ligand PD-L1 inhibitors and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibodies have been approved for the treatment of advanced hepatocellular carcinoma...
Tomasz J Nowak,Michael P Muehlenbein
Tomasz J Nowak
Sexual immune dimorphism refers to the distinct differences in immune responses between males and females, influenced by genetic, hormonal, developmental, social, and behavioral factors. These differences, shaped by evolutionary pressures, ...
Comprehensive analysis of RFC4 as a potential biomarker for regulating the immune microenvironment and predicting immune therapy response in lung adenocarcinoma [0.03%]
RFC4作为潜在生物标志物调节肺癌免疫微环境及预测免疫治疗反应的全面分析
Jianqing Zheng,Na Lin,Bifen Huang et al.
Jianqing Zheng et al.
Background: Replication factor C subunit 4 (RFC4) is crucial for initiating DNA replication via DNA polymerase δ and ϵ and is overexpressed in various cancers. However, its relationship with the tumor immune microenviro...