Protective IgM-mediated immunity against Vibrio anguillarum in Atlantic cod with evolutionary losses of mhc class II and cd4 [0.03%]
Alexandra Jonsson,Adrián López-Porras,Simen Foyn Nørstebø et al.
Alexandra Jonsson et al.
The unique adaptive immune system of the Atlantic cod (Gadus morhua), with genetic loss of the mhc class II and cd4, poses questions about the protective role of specific antibodies in this species. We investigate the IgM response against V...
Aikaterini Kyriakou,Aikaterini Patsatsi
Aikaterini Kyriakou
Bimodal onset and pan-cancer uniformity of immune-mediated liver injury: a retrospective cohort study [0.03%]
Jiaojiao Song,Biying Xu,Lan Yu et al.
Jiaojiao Song et al.
Background: Immune-mediated liver injury (IMLI) is a critical adverse event in patients treated with PD-1/PD-L1 inhibitors. The study aims to characterize the clinical heterogeneity, temporal dynamics, and immunological d...
Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata [0.03%]
Jesus Gay-Mimbrera,Pedro Jesús Gómez-Arias,Pablo Álvarez-Heredia et al.
Jesus Gay-Mimbrera et al.
Introduction: Alopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss ranging from mild, self-limiting episodes to severe and chronic forms. While prior research has primarily focused on les...
Modulation of the immune microenvironment using nanomaterials: a new strategy for tumor immunotherapy [0.03%]
Haozhe Piao,Yuxin Jiang,Shengbo Jin et al.
Haozhe Piao et al.
The complexity of the tumor immune microenvironment (TIME), which is composed of mainly tumor cells, immune cells, and cytokines, is a major obstacle limiting the effectiveness of immunotherapy, and the interactions among these factors in t...
Toll-like receptor-mediated immune imbalance in asthma: controversies, breakthroughs, and future directions [0.03%]
Xinyi Xu,Ruihan Yu,Zhuoqun Yang et al.
Xinyi Xu et al.
As a chronic inflammatory illness of the respiratory system, asthma occurs due to various factors and is characterized by a T helper 2 (Th2)-skewed immune response, airway hyperresponsiveness, and reversible airflow obstruction. Toll-like r...
Mateusz de Mezer,Natalia Dolata,Janina Markowska et al.
Mateusz de Mezer et al.
Uterine fibroids are benign tumors that occur in a large proportion of women and interfere with the proper functioning of this organ. One of the factors leading to these proliferative changes appears to be the appearance of extracellular ma...
Single-cell technologies and spatial transcriptomics: decoding immune low - response states in endometrial cancer [0.03%]
Yumeng Li,Hua Qiu,Zhenzhen Zhao et al.
Yumeng Li et al.
Globally, endometrial cancer continues to impact a significant number of women. Immunotherapy provides those suffering from advanced or relapsed disease hope, but an important barrier is still the absence of trustworthy predictive biomarker...
The quantity and quality of B-cell immunity against SARS-CoV-2 in children with cancer and hematological diseases [0.03%]
Eva Tiselius,Emil Sundberg,Amanda Ramilo Amor et al.
Eva Tiselius et al.
Background: Our understanding of protective immunity after natural viral infections in children with cancer and hematological diseases is restricted. Current cancer treatments cause significant immunosuppression, affectin...
Hs-CRP/HDL-C ratio as a predictive inflammatory-lipid marker for sarcopenia: evidence from NHANES 2015-2018 [0.03%]
Xin-Yan Guo,Liang-Wen Li
Xin-Yan Guo
Objective: This study aimed to investigate the association between the high-sensitivity C-reactive protein/high-density lipoprotein cholesterol (Hs-CRP/HDL-C) ratio and sarcopenia among U.S. population by using composite ...