In vitro models of the gut-liver axis: what we've learned and what remains to be built [0.03%]
体外胃肠道-肝脏轴模型：已取得的成果与未来展望
Jong Hwan Sung,Raehyun Kim
Jong Hwan Sung
The gut-liver axis maintains metabolic homeostasis and immune regulation through continuous bidirectional communication, and its dysregulation contributes to a range of metabolic, inflammatory, and immune-mediated diseases. Integrated gut-l...
Integrative multi-omics reveals that downregulation of HLA-DPA1/DPB1 drives macrophage immune-metabolic dysregulation in pediatric asthma [0.03%]
整合多组学分析揭示儿童哮喘中HLA-DPA1/DPB1下调导致巨噬细胞免疫代谢失调
Yuchen Wen,Zefan Du,Zhiyuan Zhong et al.
Yuchen Wen et al.
Background: Pediatric asthma (PA) is a prevalent chronic respiratory disease. Emerging evidence suggests that dysregulated macrophage heterogeneity and immune-metabolic crosstalk contribute to disease pathogenesis, yet sp...
Editorial: Microbiota-immune interactions: a new frontier in cancer treatment optimization [0.03%]
述评：微生物群-免疫相互作用在癌症优化治疗中的新前沿地位
Stephen Blake,Lorenzo Mortara,Sheila Spada
Stephen Blake
Interleukin-15 correlates with cytotoxic immune networks in cervical tuberculous lymphadenitis [0.03%]
细胞毒性免疫网络与颈淋巴结结核性淋巴结炎中的白介素-15相关性研究
Soumaya Bchiri,Khadija Bahrini,Rosane M B Teles et al.
Soumaya Bchiri et al.
Introduction: Cervical tuberculous lymphadenitis (CTL) represents a localized manifestation of Mycobacterium tuberculosis infection in which immune responses are organized within lymphoid tissue. While cytotoxic lymphocyt...
Weighted gene co-expression network analysis reveals key genes and lncRNAs in Bos indicus chronically infected with Johne's disease [0.03%]
加权基因共表达网络分析揭示Bos indicus慢性感染贾第氏病的关键基因和长链非编码RNA
Abhisek Sahu,Mohd Abdullah,Saurabh Gupta et al.
Abhisek Sahu et al.
Background: Johne's disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteric disease affecting cattle worldwide, with considerable economic implications for dairy producers. MAP is a...
The relationship between gut microbiota and cancer immune response and immunotherapy [0.03%]
肠道菌群与肿瘤免疫响应和免疫治疗的关系
Yue Jia,Yuechuan Liu,Jin Liu
Yue Jia
The gut microbiota critically regulates cancer immunity and immunotherapy outcomes. It does so through complex, bidirectional interactions with the host immune system. Key microbial metabolites drive this process. These include short-chain ...
Chimeric antigen receptor technology: an emerging translational immunotherapy in nonneoplastic diseases [0.03%]
嵌合抗原受体技术：非肿瘤疾病的转化免疫治疗新策略
Sijie Zhou,Yuan Li,Jiulu Zhao et al.
Sijie Zhou et al.
Background: One of the most significant recent advancements in cancer immunotherapy is the development of chimeric antigen receptor (CAR) technology. More recently, this approach has been gradually modified for the resear...
Stratified lymph node yield thresholds after neoadjuvant immunochemotherapy: a surgical benchmark for survival in oral squamous cell carcinoma [0.03%]
新辅助免疫化疗后的分层淋巴结切除量阈值：口腔鳞癌生存外科标准指标
Shuai Yuan,Yunshuang Hu,Yalin Hou et al.
Shuai Yuan et al.
Background: The adequacy of neck dissection following neoadjuvant immunotherapy combined with chemotherapy (NICT) for locally advanced oral squamous cell carcinoma (OSCC) lacks evidence-based benchmarks. This study aimed ...
Zhen Li,Dongping Yu,Lingyong Liu et al.
Zhen Li et al.
Background: Perforin and granzyme B are key effector molecules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Their expression profiles in hepatobiliary surgical patients and the relative contributions o...
A diagnostic signature derived from NK cell related genes in prostate cancer: insights from integrated scRNA-seq and bulk RNA-seq analyses with functional validation of KIT [0.03%]
基于整合单细胞和批量测序分析的NK细胞相关基因在前列腺癌中的诊断标志及KIT的功能验证
Zhengjun Chen,Fang Zhou,Jingzhi Tian et al.
Zhengjun Chen et al.
Background: Prostate cancer is one of the most common malignant tumors of the male genitourinary system. The impaired activity of natural killer (NK) cells observed in prostate cancer may contribute to immune evasion. Thi...