The TPx protein of Taenia solium metacestode regulates Treg and Th17 cell differentiation via the TGF-β/Smad signaling pathway [0.03%]
猪囊尾蚴TPx蛋白通过TGF-β/Smad信号通路调控Treg和Th17细胞分化
Xiaoqing Sun,Qianqian Mu,Biying Zhou
Xiaoqing Sun
Introduction: The immunopathogenesis of cysticercosis remains elusive. This study investigates the effects of Taenia solium metacestode-derived thioredoxin peroxidase (TPx) protein on regulatory T (Treg) cells and T helpe...
Editorial: Community series in innate immunity: platelets and their interaction with other cellular elements in host defense and disease pathogenesis, volume II [0.03%]
述评：先天免疫系列之二：血小板与宿主防御和疾病发生发展中的其他细胞间的相互作用
Meganathan Kannan,Firdos Ahmad,Esaki M Shankar
Meganathan Kannan
Case Report: Infant with vaccine-associated paralytic poliomyelitis unveils global disparities in care for inborn errors of immunity [0.03%]
案例报告：一名患疫苗相关麻痹性脊髓灰质炎的婴儿揭开了先天性免疫缺陷全球治疗差异的一角
Chee Mun Chan,Elisabeth Sue Shuen Fong,Daryl Yuan Chong Yeo et al.
Chee Mun Chan et al.
Severe combined immunodeficiency (SCID) is a life-threatening inborn error of immunity (IEI) that is potentially curable when diagnosed early but is associated with high morbidity and mortality when recognition is delayed. In settings witho...
Colorectal cancer-derived extracellular vesicles: at the crossroads of the tumor microenvironment and gut microbiota [0.03%]
结直肠癌来源的细胞外囊泡：肿瘤微环境和肠道微生物群的交汇点
Hao Li,Wei Zhang,Wenhui Yan et al.
Hao Li et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. The clinical treatment faces multiple challenges of significant tumor heterogeneity, prevalence of chemo-resistance, low response rate to i...
Seizure phenotypes and short-term prognosis in neonatal lupus: a multicenter retrospective cohort in China [0.03%]
中国新生儿狼疮癫痫表型和短期预后：一项多中心回顾性队列研究
Wenqiang Sun,Xinyun Jin,Yihui Li et al.
Wenqiang Sun et al.
Objectives: Neonatal lupus erythematosus (NLE) is an antibody-mediated autoimmune disorder that can affect neurologic outcomes. Seizures are an uncommon but clinically important phenotype. This study assessed clinical fea...
Multicenter Study
Frontiers in immunology. 2026 Feb 5:17:1721089. DOI:10.3389/fimmu.2026.1721089 2026
Surgical removal of Waldeyer's ring and long-term risk of Sjögren's syndrome: a population-based cohort study investigating the mucosal immune link [0.03%]
韦尔德耶氏环的外科切除与长期患舍格伦综合征风险的关系：一项基于人群的队列研究，探讨黏膜免疫之间的联系
Hua-Wei Chi,Chia-Hung Su,Yu-Hsun Wang et al.
Hua-Wei Chi et al.
Background: The palatine tonsils and adenoids are critical inductive sites for the mucosa-associated lymphoid tissue (MALT) system, educating B cells for salivary defense. While their removal is common, the long-term impa...
Association of SARS-CoV-2 infection with long-lasting increase in circulating IL-32 levels [0.03%]
SARS-CoV-2感染与持续性循环IL-32水平升高有关联
Lorenzo Miano,Elena Sinopoli,Alessandro Cherubini et al.
Lorenzo Miano et al.
Background & aims: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has a wide spectrum of clinical presentations ranging from asymptomatic viral replication to hyper-inflammatory syndrome and respir...
Observational Study
Frontiers in immunology. 2026 Feb 6:17:1739258. DOI:10.3389/fimmu.2026.1739258 2026
Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion [0.03%]
记忆样CD8⁺ T细胞通过减少TCR信号转导而非增加衰竭来适应持续刺激而缺乏PD-1
Mélanie Charmoy,Julia M Maier,Tania Wyss et al.
Mélanie Charmoy et al.
CD8+ T cells respond to persistent stimulation during chronic viral infection by stably expressing co-inhibitory receptors and other exhaustion-related molecules. Here we addressed how memory-like CD8+ T (TML) cells, which sustain the immun...
Role of trained immunity in DCs and macrophages in the induction of Th2 responses and allergy treatment. What do we know? [0.03%]
训练免疫在DC和巨噬细胞诱导Th2反应及过敏治疗中的作用。我们了解多少？
Hannah Ruth Schiller,Carola Zeigermann,Stefan Schülke
Hannah Ruth Schiller
In a process termed trained immunity activated dendritic cells (DCs) and macrophages undergo distinct metabolic changes that contribute to their effector function: While certain activated DC subsets and M1 macrophages undergo a switch towar...
Metabolic control of neuroinflammation: focus on itaconate and its derivatives in CNS disorders [0.03%]
神经炎症的代谢调控：ITA及其衍生物在中枢神经系统疾病中的作用:focus on itaconate和其衍生物在中枢神经系统疾病中的作用
Ying Wang,Shihui Liu,Weijie Zhu et al.
Ying Wang et al.
The activation of microglia, which are the resident immune cells of the central nervous system (CNS), underpins the pathogenesis of neuroinflammatory and neurodegenerative diseases. Metabolic reprogramming has recently been recognized as a ...