Immune characteristics of olfactory ensheathing cells and repair of nerve injury [0.03%]
嗅鞘细胞的免疫特性及其对神经损伤修复的作用研究
Ding-Yi Chen,Wen-Jun Zhang,Cheng Zuo et al.
Ding-Yi Chen et al.
The process of nerve injury is accompanied by the change of inflammatory microenvironment, which is not conducive to axonal regeneration and hinders the repair of injured nerve. Therefore, looking for a way to improve the inflammatory attac...
Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights [0.03%]
关于泛发性脓疱型银屑病并发 Halopeau 连续肢端皮炎的 Spesolimab 治疗：病例报告和机制研究
Xin-Yi Hou,Hai-Lu Xiao,Jing-Yu Wang et al.
Xin-Yi Hou et al.
A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient re...
The role of microglia in multiple sclerosis: implications for treatment with Bruton's tyrosine kinase inhibitors [0.03%]
少突胶质细胞在多发性硬化症中的作用：布鲁顿酪氨酸激酶抑制剂治疗的含义
Patrick Vermersch,Laura Airas,Thomas Berger et al.
Patrick Vermersch et al.
Background: Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive fo...
Persistent reduction of Bifidobacterium longum in the infant gut microbiome in the first year of age following intrapartum penicillin prophylaxis for maternal GBS colonization [0.03%]
产时青霉素预防性治疗后母体GBS定植的婴儿肠道微生物组中Bifidobacterium longum在第一年内的持续降低
Jana Lucia Teuscher,Mariia Lupatsii,Simon Graspeuntner et al.
Jana Lucia Teuscher et al.
Introduction: Group B Streptococcus is a significant cause of early-onset disease in term newborns, with a global incidence of 0.41/1000 live births. Intrapartum antibiotic prophylaxis (IAP) has reduced EOD incidence by o...
Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection [0.03%]
常见变量免疫缺陷病的肉芽肿性淋巴细胞性间质性肺疾病：临床、免疫学、功能和放射影像学研究及具有挑战性的慢性CMV感染管理难题
Mattia Moratti,Gioacchino Schifino,Francesco Baccelli et al.
Mattia Moratti et al.
Background: Common variable immune deficiency (CVID) is the most prevalent inborn error of immunity (IEI), marked by diverse clinical-immunological phenotypes and significant immune-dysregulation, including granulomatous ...
Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles [0.03%]
犬自然杀伤细胞单细胞图谱鉴定出不同循环和驻留组织基因型
Aryana M Razmara,Marshall Lammers,Sean J Judge et al.
Aryana M Razmara et al.
Introduction: Natural killer (NK) cells in mice and humans are key effectors of the innate immune system with complex immunoregulatory functions, and diverse subsets have been identified with distinct characteristics and ...
Dietary phosphorus restriction induced phospholipid deficiency, endoplasmic reticulum stress, inflammatory response and gut microbiota disorders in Lateolabrax maculatus [0.03%]
磷限制性 diet 诱导石斑鱼晚白班鱼体内的磷脂缺乏、内质网压力、炎症反应和肠道微生物群失调
Zixiang Wu,Jiarong Guo,Kangle Lu et al.
Zixiang Wu et al.
This study evaluated the effects of low phosphorus on spotted seabass (Lateolabrax maculatus) from the perspective of phospholipid content and function, endoplasmic reticulum (ER) stress, inflammatory response and gut microbiota. Two diets ...
Mapping autoantibody targets of full-length C-reactive protein in systemic lupus erythematosus: importance for neutrophil function and classical complement activation [0.03%]
系统性红斑狼疮中C-反应蛋白全长自身抗体靶标的图谱：对中性粒细胞功能和经典补体激活的意义
Jesper Karlsson,Lina Wirestam,Hanna Duàn et al.
Jesper Karlsson et al.
C-reactive protein (CRP) is an important pattern recognition molecule of innate immunity. Autoantibodies targeting CRP are common in patients with systemic lupus erythematosus (SLE) and the levels correlate with disease activity. The purpos...
Single-cell RNA-seq uncovers lineage-specific regulatory alterations of fibroblasts and endothelial cells in ligamentum flavum hypertrophy [0.03%]
单细胞RNA测序揭示纤维环增生中成纤维细胞和内皮细胞谱系特异性调节改变
Yongxin Chen,Jue Zhang,Xincheng Feng et al.
Yongxin Chen et al.
Background: Lumbar spinal stenosis (LSS) represents a major global healthcare burden resulting in back pain and disorders of the limbs among the elderly population. The hypertrophy of ligamentum flavum (HLF), marked by fi...
The NLRP3 inflammasome: a therapeutic target of phytochemicals in treating atherosclerosis (a systematic review) [0.03%]
NLRP3炎性小体：植物化学物质治疗动脉粥样硬化的作用靶点(系统综述)
Yongchao Liu,Qianyi Wu,Jing Shao et al.
Yongchao Liu et al.
Atherosclerosis (AS) is a chronic inflammatory disease characterized by the gradual accumulation of plaques in arterial walls, with its pathogenesis remaining incompletely understood. Recent studies have highlighted that development of AS i...