Distribution and molecular drivers of the 21-gene recurrence score in early breast cancer with low, intermediate, and high estrogen receptor expression [0.03%]
低、中和高强度雌激素受体表达的早期乳腺癌中21基因复发评分的分布及其分子驱动因素
Shuai Li,Jiahui Huang,Yifei Zhu et al.
Shuai Li et al.
Background: Estrogen receptor (ER)-low human epidermal growth factor receptor 2 (HER2)-negative breast cancer shares similar pathological and molecular features with triple-negative breast cancer, yet the utility of the 2...
Interplay between microRNAs and TGF-β signaling in T cells: implications for Th9 differentiation and immune pathogenesis [0.03%]
microRNA与T细胞中TGF-β信号的相互作用对Th9分化及免疫病理的意义
Tae Sung Kim,Yun-Ji Lim,WanJun Chen
Tae Sung Kim
Since the discovery of microRNAs (miRNAs) in 1993, they have been established as key post-transcriptional regulators of immune cell function. In particular, miRNAs have emerged as key modulators of CD4+ T cell activation and differentiation...
Blocking CD30 on CD19 CAR T cells augments their functional capacities against B-cell leukemia/lymphoma [0.03%]
阻断CD30可增强CD19CAR-T细胞对B系白血病/淋巴瘤的功能效应
Tim Schlierkamp-Voosen,Markus Barden,Helena Janning et al.
Tim Schlierkamp-Voosen et al.
Adoptive therapy with CD19 chimeric antigen receptor (CAR) T cells is effective against B-cell malignancies; however, T-cell activation rapidly declines, increasing the risk of early leukemia relapses. To augment CD19 CAR T-cell functionali...
Determinants of success and failure of antibody-based strategies against respiratory viruses: insights from RSV and SARS-CoV-2 [0.03%]
针对呼吸道病毒的抗体策略成功与失败的原因及其对RSV和SARS-CoV-2的启示
Hai Guo,Hongshu Wang,Shutong Wu et al.
Hai Guo et al.
Respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represent two extremes in the outcome of antibody-based interventions. The long-acting monoclonal antibody nirsevimab has achieved durable, p...
Upadacitinib for atopic dermatitis induced by secukinumab in patients with refractory ankylosing spondylitis:a case report [0.03%]
阿那白滞素诱导的特应性皮炎患者使用乌帕替尼治疗难治性强直性脊柱炎的一项病例报告
Jinxia Fang,Shaobiao Pan
Jinxia Fang
Ankylosing spondylitis (AS) is a chronic inflammatory disease that primarily affects the sacroiliac joints, spine, and peripheral joints. The widespread application of biological agents has led to significant clinical improvements in the ma...
Adapting CAR-T and CAR-Treg cancer therapies for autoimmunity: innovations and challenges [0.03%]
CAR-T和CAR-Treg细胞治疗自身免疫病：创新与挑战
Michael D Lovelace,Kelly Barrett,Sarah Thomas Broome et al.
Michael D Lovelace et al.
The application of Chimeric Antigen Receptor T-cell (CAR-T), CAR-engineered regulatory T cell (CAR-Treg) and hematopoietic stem cell (HSC) therapies has grown in recent years, driven by an increasing demand for robust, antigen-specific T ly...
PARylation-centric crosstalk: orchestrating immune evasion and multidrug resistance in ovarian cancer [0.03%]
以PARylation为中心的相互作用：在卵巢癌中协调免疫逃避和多药耐药性
Lin Hou,Mengwen Zhang,Weihua Tong et al.
Lin Hou et al.
Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Beyond PARylation, div...
In silico design and experimental validation of a multi-epitope vaccine candidate against Helicobacter hepaticus associated chronic liver inflammation [0.03%]
与Helicobacter hepaticus相关慢性肝炎的多表位疫苗候选产品的计算机设计及实验验证
Liangliang Weng,Zhang Huijie,Ni Man et al.
Liangliang Weng et al.
Background: Helicobacter hepaticus is an emerging enterohepatic pathogen associated with chronic gastrointestinal and hepatic inflammatory disorders. Despite its clinical relevance, effective vaccination strategies remain...
A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model [0.03%]
一种针对猪模型的通过肌肉和皮内注射具有免疫原性的沙眼衣原体CPAF-STING激动剂缀合疫苗
Leonie Bettin,Christine Unterweger,Maximiliane Dippel et al.
Leonie Bettin et al.
Introduction: Chlamydia trachomatis (Ct) is the most common bacterial cause of sexually transmitted infection worldwide. Given the limited effectiveness of current Ct screening and treatment programs, alongside the lack o...
Proteomic insights into aprotinin's immunomodulatory effects in attenuating renal fibrosis in a unilateral ureteral obstruction model [0.03%]
抗纤溶酶对异侧输尿管梗阻模型中肾脏纤维化的作用及机理的蛋白质组学研究
Xinyu Wang,Ying Shen,Danlei Chen et al.
Xinyu Wang et al.
Background: Chronic kidney disease involves progressive fibrosis and immune dysregulation. Aprotinin, a broad-spectrum serine protease inhibitor, has shown dose-dependent renal effects, but its role in obstructive nephrop...