Baseline neutrophil-to-lymphocyte ratio combined with SLEDAI predicts lupus low disease activity state at 1 year: a cohort study [0.03%]
基线中性粒细胞与淋巴细胞比率联合SLEDAI预测一年后狼疮低疾病活动状态：一项队列研究
Yadan Zou,Ruohan Yu,Kun Yang et al.
Yadan Zou et al.
Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease in which treat-to-target management increasingly emphasizes attainment of Lupus Low Disease Activity State (LLDAS). Complete blood count...
The immune microenvironment: a key regulator of ovarian function during ovarian aging [0.03%]
免疫微环境：卵巢衰老过程中卵泡功能的关键调节因素
Tingting Lin,Wei Zhao,Yaoqing Xie et al.
Tingting Lin et al.
The ovary is a highly dynamic organ characterized by intense biosynthetic activity, cyclical tissue remodeling, and elevated metabolic flux. Within this demanding milieu, precise immune regulation is paramount: tightly coordinated tissue re...
Exploratory investigation of changes in blood transcriptome following mepolizumab treatment for asthma [0.03%]
美普兹单抗治疗哮喘后血液转录组变化的探索性研究
Mitchell Pitlick,Mrunal K Dehankar,Chantal E McCabe et al.
Mitchell Pitlick et al.
Objective: To evaluate the effects of mepolizumab therapy on the blood transcriptome in patients with severe eosinophilic asthma (SEA) and to determine whether changes in gene expression predict responsiveness to mepolizu...
Ozone major blood ozonation in the management of dermatomyositis: a case report [0.03%]
高浓度臭氧自体血回输疗法治疗皮肌炎1例报告
Yunbo Xie,Xinyu Cui,Jiangang Liu et al.
Yunbo Xie et al.
Objective: This case report describes the potential clinical benefit and safety of ozone major blood ozonation (O3-MBO) in the treatment of glucocorticoid (GC)-dependent dermatomyositis. ...
Molecular studies on the impact of microbiome on anticancer drug resistance [0.03%]
分子研究：肠道微生物组对癌症药物耐药性的影响
Ke Zhou,Ping Lu,Hongli Xu et al.
Ke Zhou et al.
Cancer remains a leading global health challenge, with drug resistance posing a critical barrier to the durable efficacy of anticancer therapies, including chemotherapy, immunotherapy, and targeted treatments. Growing evidence highlights th...
Nils Kurzen,Stefan Weißinger,Hjalmar Kurzen
Nils Kurzen
Background: Chronic inflammation represents a central mechanism underlying the persistence of immune-mediated diseases. Unlike acute inflammation, which resolves through coordinated regulatory checkpoints and active resol...
A CDK4/6 inhibitor-armed oncolytic adenovirus reverses T cell exhaustion through the Rb-p65-CCL5 pathway and potentiates the antitumor activity of anti-PD-1 or CAR-T therapy in colorectal cancer [0.03%]
一种CDK4/6抑制型武装溶瘤腺病毒通过Rb-p65-CCL5通路逆转T细胞衰竭并增强抗PD-1或CAR-T治疗结直肠癌的抗肿瘤活性
Dan Zhou,Beibei Ran,Lingkai Kong et al.
Dan Zhou et al.
Introduction: The efficacy of oncolytic adenoviruses in colorectal cancer models is constrained by a treatment-induced limitation: the high-dose, repetitive administration required for sustained oncolysis promotes chronic...
Gregory Todd Pharr,Sonja Härtle,Nandor Nagy
Gregory Todd Pharr
Circular RNAs as molecular bridges: dual regulation of ferroptosis and immunity in cancer [0.03%]
circular RNA分子桥梁作用：对癌症中铁死亡和免疫的双重调控
Songbai Xu,Peiyi Liang,Tie Lin et al.
Songbai Xu et al.
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules generated by back-splicing events of precursor mRNAs, characterized by superior structural stability, strict tissue specificity, and diverse regulatory functions. ...
Editorial: Neutrophil function and dysfunction: pathways, impact, and therapeutic insights [0.03%]
社论：中性粒细胞的正常与异常功能：作用途径、影响及治疗启示
Baochen Fang,Mengjie Li,Yiwei Zhu et al.
Baochen Fang et al.