Innate and adaptive immune patterns in hospitalised COVID-19 patients: a framework for precision monitoring in viral and inflammatory syndromes [0.03%]
住院COVID-19患者的先天性和适应性免疫模式：病毒性和炎症综合征精准监测的框架
Salvatore Corrao,Raffaella Mallaci Bocchio,Salvatore Scibetta et al.
Salvatore Corrao et al.
Background: Understanding immune responses in viral infections such as COVID-19 is crucial for identifying patients at risk of clinical deterioration. Profiling innate and adaptive immune components may provide a basis fo...
Observational Study
Frontiers in immunology. 2026 Feb 4:16:1683748. DOI:10.3389/fimmu.2025.1683748 2026
Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia [0.03%]
凶险性前置胎盘自然分娩的临床分析
Hadida Yasmin,Tamali Roy,Chiara Agostinis et al.
Hadida Yasmin et al.
Introduction: Aberrant complement activation can cause damage to newly formed fetal-derived structures and excessive inflammatory response at the feto-maternal interface, contributing to pregnancy-related complications, i...
Persistent neutrophil activation despite count normalization suggests immune dysregulation in exertional heat stroke [0.03%]
尽管中性粒细胞计数恢复正常但中性粒细胞活化持续激活提示暴晒性中暑患者免疫调节功能障碍
Yue Wang,Siya Xu,Zhongzhi Tang et al.
Yue Wang et al.
Background: The role of neutrophils in exertional heat stroke (EHS), a life-threatening condition characterized by systemic inflammation, remains poorly defined. This study aimed to characterize the longitudinal profiles ...
Contrasted modifications of IgM and IgT repertoires induced by high- and low-virulent infectious pancreatic necrosis virus strains in rainbow trout (Oncorhynchus mykiss) [0.03%]
不同毒力传染性胰腺坏死病病毒诱导虹鳟免疫球蛋白M和T的差异响应
Sofie Navelsaker Thommessen,Luc Jouneau,Rosario Castro et al.
Sofie Navelsaker Thommessen et al.
Introduction: Infectious pancreatic necrosis virus (IPNV) is a significant pathogen in salmonid aquaculture, with virulence determined mainly by amino acid residues in the VP2 capsid protein. ...
CX3CL1/CX3CR1 axis in liver disease: context-dependent roles and balance [0.03%]
肝病中CX3CL1/CX3CR1轴的作用及平衡：取决于具体情况
Jing Liu,Zhen Guo,Xin Zheng
Jing Liu
This review provides a systematic and critical examination of the multifaceted roles of the CX3CL1/CX3CR1 axis in liver diseases. We emphasize its context-dependent duality-exhibiting both pro- and anti-inflammatory, pro- and anti-fibrotic,...
Pathogenesis and intervention strategies for metabolic dysfunction-associated fatty liver disease from the perspective of the gut-microbiota-liver axis [0.03%]
从肠-菌群-肝脏轴视角出发探究代谢紊乱相关非酒精性脂肪肝病的发生机制与干预策略
Jiabao Liao,Ze Zhou,You Lv et al.
Jiabao Liao et al.
Trillions of microorganisms in the human gut are important regulators of health, and the gut and liver have a symbiotic relationship with them. The study found that there is bidirectional communication of substances and signals between the ...
TFE3 fusion proteins drive TFE3 rearranged renal cell carcinoma progression via PGC-1α-mediated fatty acid oxidation [0.03%]
TFE3融合蛋白通过PGC-1α介导的脂肪酸氧化驱动TFE3重排肾细胞癌进展
Fan Feng,Yanhao Xu,Zhenggen Deng et al.
Fan Feng et al.
Introduction: TFE3 rearranged renal cell carcinoma (TFE3 rRCC) is a distinct and aggressive subtype of RCC characterized by poor prognosis. While TFE3 fusion proteins are central to its pathogenesis, their specific roles ...
T cell and monocyte activation in concert with hematopoietic stem cell interactions shapes the post-allogeneic transplant immune landscape in poor graft function [0.03%]
共济失调移植后的免疫景观受T细胞和单核细胞激活与造血干细胞相互作用的影响并在功能较差的移植物中成形
Ashvind Prabahran,Zhijie Wu,Shouguo Gao et al.
Ashvind Prabahran et al.
Introduction: Post-allogeneic stem cell transplantation (alloSCT) can be complicated by poor graft function (PGF), a life-threatening condition characterized by complete donor chimerism alongside persistent multilineage c...
Single-cell and spatial transcriptomics reveal transplant-associated T cells and myeloid cells in human liver transplantation [0.03%]
单细胞和空间转录组揭示了人类肝脏移植相关的T细胞和髓系细胞
Tianyang Zhou,Kun Guo,Chengyong Dong et al.
Tianyang Zhou et al.
Background: Liver transplantation is the only effective way for end-stage liver disease. Rejection remains the leading cause of graft failure. The dynamic changes of intrahepatic immune cells involved in rejection are not...
Senescent endothelial cells: key commanders of the cellular communication network within atherosclerotic plaques [0.03%]
衰老内皮细胞：动脉粥样硬化斑块中细胞通讯网络的主要指挥官
Fujia Xie,Cheng Xi,Guoqing Bao et al.
Fujia Xie et al.
Endothelial cell senescence, once considered a passive manifestation of vascular aging, is now recognized as an active driver of atherosclerosis. Senescent endothelial cells (sECs) exhibit distinct morphological and molecular hallmarks, inc...