Efgartigimod in the treatment of immune checkpoint inhibitor-related myasthenia gravis -myositis overlap syndrome: a case report [0.03%]
艾加替莫ド治疗免疫检查点抑制剂相关重症肌无力-炎性肌病重叠综合征1例报告
Ke Li,Juanjuan Hu,Zhiji Gan et al.
Ke Li et al.
Background: A subset of cancer patients receiving monoclonal antibody PD-1/PD-L1 inhibitors may develop immune checkpoint inhibitor (ICI)-related neurological complications, such as ICI-related myasthenia gravis(MG)-myosi...
Dual inhibition of CSF-1R and IDO modulates the fibrotic and immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma [0.03%]
CSF-1受体和IDO的双重抑制可调节胰腺导管腺癌的纤维化及免疫抑制型肿瘤微环境
Lara C Avsharian,Suvithanandhini Loganathan,Nancy D Ebelt et al.
Lara C Avsharian et al.
Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive forms of solid tumors, is characterized by extensive fibrosis and an immunosuppressive tumor microenvironment (TME) that limits therapeutic efficacy. Tumor-associated macro...
Mapping therapy-responsive immune ecotypes in clear cell renal cell carcinoma through integrative omics [0.03%]
通过整合组学绘制治疗敏感的免疫生态型以研究透明细胞肾细胞癌
Zheng Zhang,Lijun He,Bin Chen et al.
Zheng Zhang et al.
Clear cell renal cell carcinoma (ccRCC) is a kidney cancer in which immune activity is closely intertwined with von Hippel-Lindau (VHL) loss, hypoxia-inducible factor (HIF) signaling, angiogenesis, hypoxia, and metabolic adaptation. Althoug...
Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities [0.03%]
银屑病的钙信号转导：从发病机制到治疗机遇
Y X Chen,D X Zhuo,F F Wang
Y X Chen
Psoriasis is a chronic inflammatory skin disease driven by the synergistic interplay between aberrant epidermal proliferation and immune imbalance, with its core pathological process centered on the IL-23/IL-17 inflammatory axis. In recent ...
Succinate-mediated metabolic alterations and signaling in RA: mechanisms and therapeutic implications [0.03%]
富马酸介导的代谢和信号转导改变在类风湿关节炎中的机制及治疗意义
Yi Fan,Naidi Wang,Chenxu Zhao et al.
Yi Fan et al.
Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation. Recent studies have revealed that immune metabolites, particularly succinate, play a critical role in its pathogenesis. In this rev...
Interactions between betaine, insulin resistance, and cognitive impairment in people with and without HIV [0.03%]
含与不含HIV人群中的甜菜碱、胰岛素抵抗和认知障碍之间的相互作用
Azin Tavasoli,Bin Tang,Mohammadsobhan S Andalibi et al.
Azin Tavasoli et al.
Background: Metabolic dysfunction and neurocognitive decline share inflammatory pathways that may be amplified in people with HIV (PWH). Prior studies suggest insulin resistance correlates with cognitive decline, while gu...
Microbiota-directed therapies for atopic dermatitis: a three-tier framework for inflammation control, immune modulation, and microbiome restoration [0.03%]
基于皮肤微生物的特应性皮炎治疗：炎症控制、免疫调节和菌群重塑三层框架
Yi Zhao,Quan Gao,Guixiu Li et al.
Yi Zhao et al.
The pathogenesis of atopic dermatitis (AD) involves cutaneous barrier dysfunction, immune dysregulation, and microbiota imbalance. Although microbiota-directed therapeutic approaches have garnered increasing attention, current evidence is h...
From associations to clinical practice: translating inflammatory-nutritional indices into a machine learning-driven model for breast cancer risk stratification with cross-ethnic validation [0.03%]
从相关性到临床实践：将炎症营养指数转化为乳腺癌风险分层的机器学习模型并进行跨种族验证
Yue Li,Ting Ding,Xiaoyan Zhou et al.
Yue Li et al.
Objectives: To evaluate inflammatory-nutritional indices in relation to breast cancer (BC) risk and mortality and develop a cross-ethnically validated prediction model. ...
A non-radioactive modified immunoprecipitation assay for diagnostic detection of anti-MDA5 antibodies in idiopathic inflammatory myopathies [0.03%]
一种非放射性免疫沉淀测定法，用于在特发性炎性肌病中诊断性检测抗MDA5抗体
Tian-De Wang,Kai-Fa Teo,Joung-Liang Lan et al.
Tian-De Wang et al.
Introduction: Anti-melanoma differentiation-associated gene 5 (MDA5) autoantibodies are clinically important in idiopathic inflammatory myopathies (IIM), but currently used screening assays may yield clinically misleading...
Immune resistance in hepatobiliary and pancreatic cancers: rethinking the tumor microenvironment beyond checkpoint blockade [0.03%]
肝胆胰癌的免疫抵抗：超越检查点抑制重新审视肿瘤微环境
Jingyi Xu,Lei Yang,Shuang Wang et al.
Jingyi Xu et al.