From linezolid to contezolid: a strategy for safe continuation of therapy in complex tuberculosis [0.03%]
从利奈唑胺到康拉唑胺：复杂性结核病安全治疗的策略
Fei Lv,Rui Lin,Li Zheng et al.
Fei Lv et al.
Background: Linezolid (Lzd) is a cornerstone for drug-resistant and complex tuberculosis (TB), but its utility is severely limited by hematological and neurological toxicities. Contezolid (Czd), a novel oxazolidinone, off...
Root metabolite profiles support a chemical-trophic filtering hypothesis for genotype- and stage-specific rhizosphere assembly in chicory [0.03%]
根代谢产物谱支持化学营养筛选假说解释菊苣种特异和阶段特异的根系微生物组装过程
Lalie Leclercq,Gaëtan Kientz,Emily Lloret et al.
Lalie Leclercq et al.
The rhizosphere is a dynamic interface where plant- and soil-derived factors jointly influence microbial community assembly. In chicory (Cichorium intybus L.), the respective roles of genotype, developmental stage, and root metabolites in s...
Bacteriophage lysins: a promising strategy for combating foodborne pathogens in food safety [0.03%]
噬菌体溶菌酶在食品安全中防控食源性致病菌中的应用展望
Jiaxin Wei,Yuying Zhang,Yubao Li et al.
Jiaxin Wei et al.
Food safety is a major public concern, with foodborne pathogens such as Staphylococcus aureus, Listeria monocytogenes, Clostridium perfringens, and Vibrio parahaemolyticus causing millions of infections and significant economic losses annua...
Functional cooperation between LIPI-4 and listeriolysin O governs intracellular replication and systemic virulence of Listeria monocytogenes [0.03%]
LIPI-4与清单溶素O的功能性协作调控单核细胞增生性李斯特菌的胞内复制及系统致病性
Zhongke Yin,Zhijie Luo,Xun Ma et al.
Zhongke Yin et al.
Background: Listeria monocytogenes (L. monocytogenes) is a facultative intracellular bacterium and the etiological agent of listeriosis, an invasive infection that disproportionately affects neonates, older adults, pregna...
Comparison of clinical characteristics in acute and early HIV-1 infection across different subtypes: a hospital-based cohort study [0.03%]
基于医院的队列研究：不同亚型急性或近期HIV-1感染者临床特征对比
Shanshan Tang,Tianyang Liu,Zifan Zhang et al.
Shanshan Tang et al.
Background: Early diagnosis and immediate antiretroviral therapy (ART) for acute and early HIV-1 infection (AEHI) effectively curb HIV transmission and restrict viral reservoir formation. However, subtype-specific transmi...
In vitro study on synergistic antifungal effects of docetaxel combined with azoles against dematiaceous fungi and Aspergillus niger [0.03%]
多西他赛联合唑类体外对抗暗色真菌和烟曲霉的协同抗真菌作用研究
Heng Zhang,Hua Ni,Mengqi Peng et al.
Heng Zhang et al.
Background: Dematiaceous fungal infections are frequently encountered in clinical practice with no unified treatment. Drug combination reduces drug resistance, and repurposed clinical drugs as synergists show promise in a...
Fermentation regulation and identification of short-chain and long-chain menaquinones (vitamin K2) from Elizabethkingia meningoseptica [0.03%]
Elizabethkingia meningoseptica发酵调控及其短链和长链甲基萘醌（维生素K2）的鉴定
Hongfei Wei,Liping You,Tianjiao Shen et al.
Hongfei Wei et al.
Menaquinone (MKs) are a group of naphthoquinone derivatives that play important roles in various aspects of human health. This study aimed to investigate the congener profiles and yields of MKs produced by Elizabethkingia meningoseptica str...
Metagenomic analysis of the gut microbiota in Cygnus cygnus and isolation, identification, and safety assessment of Bacillus [0.03%]
大天鹅肠道微生物群的元基因组分析及芽孢杆菌的分离鉴定和安全性评价
Ying Xiao,Yabin Lu,Yue Hu et al.
Ying Xiao et al.
Introduction: As a national second-class protected wild animal, the intestinal microbial community of Cygnus cygnus is highly important for health status and ecological balance. The potential application value of probioti...
Precision antimicrobials: the next paradigm shift after broad-spectrum therapy [0.03%]
精准抗菌药物：广谱抗菌疗法后的下一个范式转变
Shanmugam N R Siva,Sathish Kumar Marimuthu,Manojkumar Kumaran et al.
Shanmugam N R Siva et al.
Age-stratified respiratory viral detection patterns and exploratory environmental associations in a tertiary-care hospital testing cohort in Istanbul, Türkiye [0.03%]
土耳其伊斯坦布尔一家三级护理医院检测队列中的年龄分层呼吸道病毒检测模式及探索性环境关联
Murat Yaman,Arzu Ilki
Murat Yaman
Respiratory viral detection in large metropolitan clinical settings is shaped by age, seasonality, testing behavior, and environmental context, but these dimensions are rarely evaluated together using multiplex molecular data. Istanbul's tr...